Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort

Skerenova, Maria; Cibulka, Michal; Dankova, Zuzana; Holubekova, Veronika; Kolkova, Zuzana; Lucansky, Vincent; Dvorska, Dana; Kapinova, Andrea; Krivosova, Michaela; Petras, Martin; Baranovicova, Eva; Baranova, Ivana; Novakova, Elena; Liptak, Peter; Banovcin, Peter; Bobcakova, Anna; Rosolanka, Robert; Janickova, Maria; Stanclova, Andrea; Gaspar, Ludovit; Caprnda, Martin; Prosecky, Robert; Labudova, Monika; Gabbasov, Zufar; Rodrigo, Luis; Kruzliak, Peter; Lasabova, Zora; Matakova, Tatiana; Halasova, Erika

doi:10.1016/j.advms.2024.03.007

Cited by 1 publication

(1 citation statement)

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“…Similarly, when comparing patients who recovered to those who succumbed to the infection, the rare CGCT haplotype was associated with a heightened risk of mortality from SARS-CoV-2. The genetic variants analyzed in our study in relation to SARS-CoV-2 infection have not been extensively investigated; however, in a recent study, the OAS1/OAS3 haplotype 'GTTG' carrying a functional allele G of splice-acceptor variant rs10774671 manifested its protective function in the Delta pandemic wave [34]. Another study highlighted that a Neanderthal-derived haplotype encompassing the genes OAS1, OAS2, and OAS3 conferred protection against COVID-19, with OAS3 showing the most substantial correlations [35].…”

Section: Discussionmentioning

confidence: 99%

Gene Variants of the OAS/RNase L Pathway and Their Association with Severity of Symptoms and Outcome of SARS-CoV-2 Infection

Perez-Favila,

Sanchez-Macias,

De Lara

et al. 2024

JPM

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Introduction: The interferon pathway plays a critical role in triggering the immune response to SARS-CoV-2, and these gene variants may be involved in the severity of COVID-19. This study aimed to analyze the frequency of three gene variants of OAS and RNASEL with the occurrence of COVID-19 symptoms and disease outcome. Methods: This cross-sectional study included 104 patients with SARS-CoV-2 infection, of which 34 were asymptomatic COVID-19, and 70 were symptomatic cases. The variants rs486907 (RNASEL), rs10774671 (OAS1), rs1293767 (OAS2), and rs2285932 (OAS3) were screened and discriminated using a predesigned 5′-nuclease assay with TaqMan probes. Results: Patients with the allele C of the OAS2 gene rs1293767 (OR = 0.36, 95% CI: 0.15–0.83, p = 0.014) and allele T of the OAS3 gene rs2285932 (OR = 0.39, 95% CI: 0.2–0.023, p = 0.023) have lower susceptibility to developing symptomatic COVID-19. The genotype frequencies (G/G, G/C, and C/C) of rs1293767 for that comparison were 64.7%, 29.4%, and 5.9% in the asymptomatic group and 95.2%, 4.8%, and 0% in severe disease (p < 0.05). Conclusions: Our data indicate that individuals carrying the C allele of the OAS2 gene rs1293767 and the T allele of the OAS3 gene rs2285932 are less likely to develop symptomatic COVID-19, suggesting these genetic variations may confer a protective effect among the Mexican study population. Furthermore, the observed differences in genotype frequencies between asymptomatic individuals and those with severe disease emphasize the potential of these variants as markers for disease severity. These insights enhance our understanding of the genetic factors that may influence the course of COVID-19 and underscore the potential for genetic screening in identifying individuals at increased risk for severe disease outcomes.

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Section: Discussionmentioning

confidence: 99%