Host genetic factors and susceptibility to <scp>SARS‐CoV</scp>‐2 infection

Schurr, Theodore G.

doi:10.1002/ajhb.23497

Cited by 8 publications

(9 citation statements)

References 54 publications

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“…Ongoing investigations into COVID-19 and individual genetic makeup are fueling global research to develop vaccines, prioritize individuals for treatment, and discover potential drug target candidates. 95 The antiviral drug Veklury (remdesivir) is the first and the only treatment for COVID-19 approved by the US Food and Drug Administration ( https://www.fda.gov ). Given that remdesivir is a broad-spectrum antiviral drug, better direct-target-based antiviral therapies that intervene in SARS-CoV-2-infected pathways are anticipated.…”

Section: Discussionmentioning

confidence: 99%

“…94 The virus weakens the antiviral effects of ISG products through dysregulating IFN signaling and IFN generation. 94 , 95 In acquired immunity, SARS-CoV-2 may target the CD147 spike protein of T lymphocytes. 96 Viral peptides are presented by major histocompatibility complex (MHC) Class-I molecules to CD8 + T cells (cytotoxic T cells) to kill the virus directly, while by MHC Class-II molecules to CD4 + T cells (helper T cells).…”

Section: Pathogenesis Of Sars-cov-2mentioning

confidence: 99%

“…105 The CXCR6 gene and the CCR9 gene encoding chemokine receptors are implicated in T cell differentiation and recruitment. 95 Rs11385942 in the LZTFL1 gene associated with increased SLC6A20 expression and reduced CXCR6 expression is a risk variant and is common in Europeans, Africans, and South Asians, but almost absent in the East Asians. 106 …”

Section: Autosomal Loci and Genes Associated With Covid-19mentioning

confidence: 99%

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Human genetic basis of coronavirus disease 2019

Deng

Xue

Yuan

2021

Sig Transduct Target Ther

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Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in considerable morbidity and mortality worldwide. COVID-19 incidence, severity, and mortality rates differ greatly between populations, genders, ABO blood groups, human leukocyte antigen (HLA) genotypes, ethnic groups, and geographic backgrounds. This highly heterogeneous SARS-CoV-2 infection is multifactorial. Host genetic factors such as variants in the angiotensin-converting enzyme gene (ACE), the angiotensin-converting enzyme 2 gene (ACE2), the transmembrane protease serine 2 gene (TMPRSS2), along with HLA genotype, and ABO blood group help to explain individual susceptibility, severity, and outcomes of COVID-19. This review is focused on COVID-19 clinical and viral characteristics, pathogenesis, and genetic findings, with particular attention on genetic diversity and variants. The human genetic basis could provide scientific bases for disease prediction and targeted therapy to address the COVID-19 scourge.

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Section: Discussionmentioning

confidence: 99%

Section: Pathogenesis Of Sars-cov-2mentioning

confidence: 99%

Section: Autosomal Loci and Genes Associated With Covid-19mentioning

confidence: 99%

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Human genetic basis of coronavirus disease 2019

Deng

Xue

Yuan

2021

Sig Transduct Target Ther

View full text Add to dashboard Cite

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“…However, one possible answer could be the host genetic background, therefore; the host genetic risk factors for acquiring infection and developing symptoms should be considered. Recently, a large number of studies have been directed toward finding genes that confer differences in susceptibility for COVID-19 infection ( Schurr, 2020 ). Some of the genetic association studies are performed based on the comparison of biobank genetic data ( Kuo et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

Association of Apolipoprotein e polymorphism with SARS-CoV-2 infection

Al-Jaf

Niranji

Ali

et al. 2021

Infection, Genetics and Evolution

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“… [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] ...…”

Section: Uncited Referencesunclassified

Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms

Saulle¹,

Vicentini²,

Clerici³

et al. 2021

Human Immunology

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Given the highly polymorphic nature of Human Leukocyte Antigen (HLA) molecules, it is not surprising that they function as key regulators of the host immune response to almost all invading pathogens, including SARS-CoV-2, the etiological agent responsible for the recent COVID-19 pandemic. Several correlations have already been established between the expression of a specific HLA allele/haplotype and susceptibility/progression of SARS-CoV-2 infection and new ones are continuously emerging. Protective and harmful HLA variants have been described in both mild and severe forms of the disease, but considering the huge amount of existing variants, the data gathered in such a brief span of time are to some extent confusing and contradictory. The aim of this mini-review is to provide a snap-shot of the main findings so far collected on the HLA-SARS-CoV-2 interaction, so as to partially untangle this intricate yarn. As key factors in the generation of antigenic peptides to be presented by HLA molecules, ERAP1 and ERAP2 role in SARS-CoV-2 infection will be revised as well.

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Host genetic factors and susceptibility to SARS‐CoV‐2 infection

Cited by 8 publications

References 54 publications

Human genetic basis of coronavirus disease 2019

Human genetic basis of coronavirus disease 2019

Association of Apolipoprotein e polymorphism with SARS-CoV-2 infection

Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms

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