Host genetic determinants of influenza pathogenicity

Lin, Tung‐Ching; Brass, Abraham L.

doi:10.1016/j.coviro.2013.07.005

Cited by 27 publications

(33 citation statements)

References 71 publications

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“…but located near exon 4, the region encoding transmembrane signal induction), have been linked to impaired signaling function and weakened host responses [8,20,21]. Likewise, SNPs of the TLR4 gene have been linked to impaired innate immunity against respiratory viruses [22,23].…”

mentioning

confidence: 99%

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza

Lee¹,

Cao²,

Ke³

et al. 2017

The Journal of Infectious Diseases

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mentioning

confidence: 99%

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza

Lee¹,

Cao²,

Ke³

et al. 2017

The Journal of Infectious Diseases

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“…The clinical course depends on the viral virulence and the infected individual: age (child or elderly), pre-existing immunity, the presence of prior morbidity affecting heart (cardiopathic disease and/or hypertension) or lungs (e.g., asthma), diabetes, pregnancy, the presence of immunosuppression are all risk factors for influenza complication [31,32]. Some genetic determinants can also play a role in the development of severe disease [33,34].…”

Section: Influenza: Epidemiology and Pandemic Preparednessmentioning

confidence: 99%

The Application of Pseudotypes to Influenza Pandemic Preparedness

2015

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Human and animal populations are constantly exposed to multiple influenza strains due to zoonotic spillover and rapid viral evolution driven by intrinsic error-prone replication and immunological pressure. In this context, antibody responses directed against the hemagglutinin protein on the surface of the virus are of importance since they have been shown to correlate with protective immunity. Serological techniques, detecting these responses, play a critical role in influenza pandemic preparedness in particular with regard to the measurement of vaccine immunogenicity. As the recent human pandemics (H1N1) and avian influenza outbreaks (H5 and H7) have demonstrated, there is an urgent need to be better prepared to assess the contribution of the antibody response to protection against newly emerged viruses and to evaluate the extent of pre-existing heterosubtypic immunity in populations. This review compares pseudotype-based assays with wild-type and viruslike particle virus assays and discusses their place in the pandemic preparedness against the influenza virus. It additionally addresses the state-of-the-art developments of pseudotypebased assays (chimeric hemagglutinins, multiplex and post-attachment) including the development and future deployment of assay kits and approaches toward standardization to both preclinical and clinical endpoints. Progress toward the development of an influenza pseudotype library for the purposes of pandemic preparedness is also outlined and discussed.

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“…For example, the first IAV pandemic of this century occurred in 2009 and it is estimated that in approximately one year, the pandemic 2009 H1N1 (pH1N1) IAV infected more than 600,000 human beings, causing near 16,000 deaths in over 200 countries [40,41]. In addition, although only H1N1 and H3N2 are circulating in humans, the avian H5, H7, and H9 subtypes eventually cross the species barrier to infect humans, representing a new and serious public health problem [13,37,[47][48][49]].…”

Section: Influenza Virus Importance In Human Healthmentioning

confidence: 99%

“…The rs2564978 SNP of CD55 is located in the minimal promoter region [139] and individuals with this genotype showed significantly lower levels of CD55 expression in comparison to those with the more frequent allele [137]. Therefore, patients who carry the T/T genotype may have more robust complement activation during IAV infection, resulting in enhanced inflammation and disease severity [47,79]. According to these results, the polymorphism rs2564978 in gene CD55 was linked to disease severity in adult Chinese cases of avian (H7N9) and human pH1N1 IAV in another study [100].…”

Section: Snps In Host Genes Affecting Iav Diseasementioning

confidence: 99%

Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans

Nogales¹,

DeDiego

2019

Pathogens

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A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA sequence. SNPs are located in coding or non-coding genomic regions and can affect gene expression or protein function by different mechanisms. Furthermore, they have been linked to multiple human diseases, highlighting their medical relevance. Therefore, the identification and analysis of this kind of polymorphisms in the human genome has gained high importance in the research community, and an increasing number of studies have been published during the last years. As a consequence of this exhaustive exploration, an association between the presence of some specific SNPs and the susceptibility or severity of many infectious diseases in some risk population groups has been found. In this review, we discuss the relevance of SNPs that are important to understand the pathology derived from influenza A virus (IAV) infections in humans and the susceptibility of some individuals to suffer more severe symptoms. We also discuss the importance of SNPs for IAV vaccine effectiveness. multiple mechanisms, although there are some differences between strains. For that genome plasticity, IAV take advantage of multiple strategies, such as alternative splicing, frameshift mechanisms, and overlapping open reading frames (ORFs) [7][8][9]. In addition, the coding capability of the viral genome is extended by encoding multifunctional proteins that act at different steps during virus infection. of synthetized vRNP, ensuring that the vRNPs are available for packaging [24]. Moreover, NEP has also other functions during IAV infection, contributing to viral budding and to regulate viral RNA synthesis. NS1 is a multifunctional protein and a key viral factor that counteracts the host antiviral responses. NS1 has been shown to inhibit the production of interferon (IFN), the activity and expression of multiple interferon-induced genes (ISG) and the processing and nuclear transport of host mRNAs causing cellular shut-off [25,26]. Segment 3 of IAV also encodes two proteins, the polymerase component PA and PA-X. PA is translated directly from the PA mRNA, whereas PA-X is translated using a +1 frameshift mechanism from the same open reading frame (ORF) [9]. Synergistically with NS1, PA-X is also able to block the cellular antiviral responses by inhibiting host protein expression. Moreover, the PA-X protein has been shown to modulate host inflammation, immune responses, apoptosis, and virus pathogenesis [25][26][27][28][29][30].

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Host genetic determinants of influenza pathogenicity

Cited by 27 publications

References 71 publications

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza

IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza

The Application of Pseudotypes to Influenza Pandemic Preparedness

Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans

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