1974
DOI: 10.1084/jem.140.6.1457
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Host Genetic Control of Recovery From Friend Leukemia Virus-Induced Splenomegaly

Abstract: The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F1 congenic mice differing only at genes within the H-2 complex. F1 mice which were H-2b/b had a high incidence of recovery from splenomegaly compared to H-2b/d or H-2b/a mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable tr… Show more

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Cited by 166 publications
(101 citation statements)
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“…The B-cell-tropic, polycythemia-inducing FV complex (35) was used for all virus challenge experiments and was from an uncloned virus stock obtained from a 10% spleen cell homogenate as previously described (8). Mice were inoculated by intravenous injection with 3,000 spleen focusforming units of FV complex diluted in 0.5 ml of phosphate-buffered balanced salt solution (PBBS) containing 2% fetal bovine serum.…”
Section: Methodsmentioning
confidence: 99%
“…The B-cell-tropic, polycythemia-inducing FV complex (35) was used for all virus challenge experiments and was from an uncloned virus stock obtained from a 10% spleen cell homogenate as previously described (8). Mice were inoculated by intravenous injection with 3,000 spleen focusforming units of FV complex diluted in 0.5 ml of phosphate-buffered balanced salt solution (PBBS) containing 2% fetal bovine serum.…”
Section: Methodsmentioning
confidence: 99%
“…FV is known to induce fatal erythroleukemia associated with severe immunosuppression when injected into immunocompetent adult mice of susceptible strains (2,27). Mice with a BALB/c background are especially susceptible to FV-induced disease because they lack immune and nonimmune mechanisms that render some other strains of mice resistant against FV replication and disease progression (5). Epitopes recognized by CD4 ϩ helper T cells and CD8 ϩ cytotoxic T lymphocytes (CTL) have been identified in the products of env and gag genes of F-MuLV (1,15,20,32,36), and a yet-unidentified immunoprotective CD4 ϩ T-cell epitope has been mapped in the MA (p15) portion of the gag gene product (23).…”
mentioning
confidence: 99%
“…focus-forming units (SFFU) of virus as described previously (9). For virus challenge experiments, mice were infected by intravenous injection of 0.5 ml of phosphate-buffered balanced salt solution containing 1% normal mouse serum and 3,000 SFFU of FV.…”
mentioning
confidence: 99%