Host Factors in Tuberculosis

Sadikot, Ruxana T.

doi:10.1007/978-981-32-9413-4_3

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…The rate at which a person produces droplets containing bacteria is also important [ 29 ]. For unclear reasons, gender is also an important determinant of acquiring TB: TB seems to affect men two times more than women worldwide [ 30 ]. In 2019, 56% of people who contracted TB were men (aged ≥ 15 years) [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

An overview of tuberculosis outbreaks reported in the years 2011–2020

et al. 2023

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Background In many countries tuberculosis (TB) remains a highly prevalent disease and a major contributor to infectious disease mortality. The fight against TB requires surveillance of the population of strains circulating worldwide and the analysis of the prevalence of certain strains in populations. Nowadays, whole genome sequencing (WGS) allows for accurate tracking of TB transmission. Currently, there is a lack of a comprehensive summary of the characteristics of TB outbreaks. Methods We systematically analyzed studies reporting TB outbreaks worldwide, monitored through WGS of Mycobacterium tuberculosis. We 1) mapped the reported outbreaks from 2011- 2020, 2) estimated the average size of the outbreaks, 3) indicated genetic lineages causing the outbreaks, and 4) determined drug-resistance patterns of M. tuberculosis strains involved in the outbreaks. Results Most data originated from Europe, Asia, and North America. We found that TB outbreaks were reported throughout the globe, on all continents, and in countries with both high and low incidences. The detected outbreaks contained a median of five M. tuberculosis isolates. Most strains causing the outbreaks belonged to lineage four, more rarely to lineage two. Reported outbreak isolates were often drug resistant. Conclusions We conclude that more WGS surveillance of M. tuberculosis outbreaks is needed. Globally standardized procedures might improve the control of M. tuberculosis infections.

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Section: Discussionmentioning

confidence: 99%

An overview of tuberculosis outbreaks reported in the years 2011–2020

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The rate at which a person produces droplets containing bacteria is also important [20]. For unclear reasons, gender is also an important determinant of acquiring TB; TB seems to affect men two times more than women worldwide [30]. In 2019, 56% of people who contracted TB were men (aged ≥ 15 years) [5].…”

Section: Study Overviewmentioning

confidence: 99%

An overview of tuberculosis outbreaks reported in the years 2011-2020

Żukowska

Zygała-Pytlos

Zabost

et al. 2022

Preprint

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Background Tuberculosis (TB) is a highly prevalent disease, with millions of people dying yearly. The fight against TB requires surveillance of the population of strains circulating worldwide and the analysis of the prevalence of certain strains in populations. Nowadays, whole genome sequencing (WGS) allows for accurate tracking of TB transmission. Currently, there is a lack of a comprehensive summary of the characteristics of TB outbreaks. Methods We systematically analyzed studies reporting TB outbreaks worldwide, monitored through WGS of Mycobacterium tuberculosis. We 1) mapped the reported outbreaks from 2011–2020, 2) estimated the average size of the outbreaks, 3) indicated genetic lineages causing the outbreaks, and 4) determined drug-resistance patterns of M. tuberculosis strains involved in the outbreaks. Results Most data originated from Europe, Asia, and North America. We found that TB outbreaks were reported throughout the globe, on all continents, and in countries with both high and low incidences. The detected outbreaks contained a median of five M. tuberculosis isolates. Most strains causing the outbreaks belonged to lineage four, more rarely to lineage two. Reported outbreak isolates were often drug resistant. Conclusions We conclude that more WGS surveillance of M. tuberculosis outbreaks is needed. Globally standardized procedures might improve the control of M. tuberculosis infections.

show abstract

Host Factors in Tuberculosis

Cited by 2 publications

References 30 publications

An overview of tuberculosis outbreaks reported in the years 2011–2020

An overview of tuberculosis outbreaks reported in the years 2011–2020

An overview of tuberculosis outbreaks reported in the years 2011-2020

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