2003
DOI: 10.1128/jvi.77.15.8181-8186.2003
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Host Factors in Positive-Strand RNA Virus Genome Replication

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Cited by 448 publications
(368 citation statements)
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“…Several yeast proteins have been identified to regulate BMV replication and translation, such as Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors and DED1. Mutations in these host proteins affected viral replication in yeast at the levels of both viral replication and gene expression (1,17,25,26,30,32,34,46). If 1a represses translation through affecting cellular proteins, then these proteins are prime candidates for the B box binding proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Several yeast proteins have been identified to regulate BMV replication and translation, such as Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors and DED1. Mutations in these host proteins affected viral replication in yeast at the levels of both viral replication and gene expression (1,17,25,26,30,32,34,46). If 1a represses translation through affecting cellular proteins, then these proteins are prime candidates for the B box binding proteins.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that VRCs are composed of virus-encoded replicationrelated proteins, viral RNAs and host factors. Furthermore, VRCs can anchor to a cellular membrane to form a specialized compartment, which protects viral RNA from degradation by host defence mechanisms, such as RNA silencing (David et al, 1992;Ahlquist et al, 2003;Ding et al, 2004;Mackenzie, 2005;Nagy & Pogany, 2008;Novoa et al, 2005;Waigmann et al, 2007). For example, the VRCs of TMV are macromolecular structures capable of replicating genomic and subgenomic RNAs, and contain viral replicase proteins, viral RNAs, and host proteins and membranes (Kawakami et al, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to the viral replication proteins, they rely on the host-cell environment for replication. All known positive-sense ssRNA viruses replicate in association with host endomembranes (Mackenzie, 2005), and different host factors participate in the process (Ahlquist et al, 2003;Whitham & Wang, 2004). Numerous studies have described the importance of post-translational modifications in regulating viral protein function during host-virus interplay, including phosphorylation, glycosylation and lipid modifications.…”
Section: Introductionmentioning
confidence: 99%