Host factors are important in determining clinical outcomes of Helicobacter pylori infection

Chiba, Tsutomu; Seno, Hiroshi; Marusawa, Hiroyuki; Wakatsuki, Yoshio; Okazaki, Kazuichi

doi:10.1007/s00535-005-1743-4

Cited by 46 publications

(40 citation statements)

References 68 publications

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“…It is still unclear whether some patients showed advanced progression of gastritis followed by gastric carcinogenesis. Many studies have revealed that multiple factors including bacterial factors, environmental factors, and the host immune response, contribute to the progression of mucosal atrophy, metaplasia, and dysplasia toward gastric cancer (3,4).…”

Section: Introductionmentioning

confidence: 99%

Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis

Tatsugami

Ito

Tanaka

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Bile acid and Helicobacter pylori (H. pylori) are important toxic factors for gastric mucosal injury. We examined the role of bile acid in promoting histologic gastritis and gastric carcinoma in Japanese patients.Methods: A total of 767 patients (452 men, mean age 51.1 years) were studied. Gastric juice was collected by gastro-endoscopic examination, and the bile acid concentration was examined by enzymatic method. The grade of histologic gastritis was evaluated by gastric biopsies, and the relationship between the bile acid concentration and the gastritis score was examined. The occurrence of gastric cancer was examined by a retrospective cohort study. CDX2/CINC1 expression in RGM-1 cells was evaluated by real-time PCR.Results: In H. pylori-positive patients, we found significant positive correlation between the bile acid concentration and the grades of atrophy/intestinal metaplasia (P < 0.01). However, we found significant negative associations between the bile acid concentrations and the histologic scores of mononuclear cell/ neutrophil infiltrations (P < 0.01). Patients with a high concentration of bile acid developed gastric cancer more frequently than those with a low concentration (P < 0.05). Cholic acid treatment significantly increased CDX2 expression in RGM-1 cells. CINC1 expression in RGM-1 cell was significantly induced by coculture with H. pylori, and the induction was reduced by glycochenodeoxycholic acid treatment.Conclusion: The bile acid in gastric juice contributes to the progression of histologic atrophy and intestinal metaplasia without inflammatory cell infiltration, followed by carcinogenesis in H. pylori-positive patients.Impact: Bile acid promotes intestinal metaplasia and gastric carcinogenesis without inflammatory cell infiltration. Cancer Epidemiol Biomarkers Prev; 21(11); 2101-7. Ó2012 AACR.

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Section: Introductionmentioning

confidence: 99%

Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis

Tatsugami

Ito

Tanaka

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…For example, epidemiologic studies demonstrate that patients with chronic hepatitis caused by hepatitis virus infection and chronic gastritis caused by Helicobacter pylori infection leads to the development of hepatocellular carcinoma and gastric cancers, respectively (Chiba et al, 2006;Ikeda et al, 2007). Similarly, it is well recognized that the incidence of colorectal cancer is significantly higher in those with inflammatory bowel disease (IBD) than in the general population (Podolsky, 2002).…”

Section: Introductionmentioning

confidence: 99%

Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation

et al. 2011

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“…The association between H. pylori infection and old age is well documented [6] . In Japan, around 50% of the general population is infected with H. pylori, with a notably increased infection rate of 70%-80% among people born before 1950 [7,8] . Early detection and eradication of H. pylori infection is an important step in eliminating risk for gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Regular arrangement of collecting venules: Does patient age affect its accuracy?

Alaboudy

Elbahrawy²,

Matsumoto³

et al. 2011

WJG

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AIM:To address the diagnostic value of the regular arrangement of collecting venules (RAC) among old age patients. METHODS: A total of 390 consecutive patients whoseHelicobacter pylori (H. pylori ) status was known and who received upper gastrointestinal endoscopy, were retrospectively studied for the presence or absence of RAC as well as gastric mucosal atrophy. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of RAC to detect normal gastric mucosa were assessed and were compared among two different age groups of patients. RESULTS:The mean age ± standard deviation (SD) of included patients (n = 390), was 62.9 ± 13 years. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of RAC to detect normal gastric mucosa were 91.7%, 66.1%, 18.8%, 99% and 68.1% respectively. Although the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of RAC among patients < 60 years (n = 139) was 94.7%, 71.2%, 46.2%, 98.1%and 76.1%, respectively, it was 80%, 64.3%, 5.1%, 93% and 64.6%, respectively, among patients ≥ 60 years (n = 251). Younger Patients (< 60 years), have highly significant rates of RAC sensitivity, positive predictive value, and accuracy (P ≤ 0.001, ≤ 0.001 and ≤ 0.02, respectively). Older patients had highly significant rates of H. pylori infection and gastric mucosal atrophy (P ≤ 0.01). CONCLUSION:Although RAC is a valuable sign for real-time identification of normal gastric mucosa, its accuracy seems to be affected by the patient's age.

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Host factors are important in determining clinical outcomes of Helicobacter pylori infection

Cited by 46 publications

References 68 publications

Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis

Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis

Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation

Regular arrangement of collecting venules: Does patient age affect its accuracy?

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