Host Enzyme Induction of Bacterial Infection

Rapoport, Morton I.; Lust, George; Beisel, William R.

doi:10.1001/archinte.1968.03640010013002

Cited by 27 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Illness (vertical broken line) is characterized by the onset of fever and bacteraemia. (Wannemacher et al, 1971a;Powanda et al, 1972), certain specific intracellular proteins of the liver such as tyrosine transaminase (Shambaugh & Beisel, 1968) and tryptophan oxygenase (Rapoport et al, 1968) have been reported to increase in rats or mice that were infected with D. pneumoniae. The small increase in free rRNA fraction in the liver of infected rats may be associated with the synthesis of such specific proteins, such as tyrosine transaminase and tryptophan oxygenase.…”

Section: Discussionmentioning

confidence: 99%

“…When the serum proteins were fractionated by electrophoresis, the major infection-related increase in synthesis was observed in the a,, a2 and ,3 fractions with a concomitant decrease in the rate of synthesis of albumin (Powanda et al, 1972). In contrast, the synthesis of total liver proteins was not significantly altered by the infectious process (Wannemacher et al, 1971a), but increased activities of hepatic tyrosine transaminase and tryptophan oxygenase have been observed in rats or mice infected with D. pneumoniae (Rapoport et al, 1968;Shambaugh & Beisel, 1968). Thus in rats infected with D. pneumoniae it would appear that the liver was stimulated to increase its synthesis of certain serum proteins and the activity of several hepatic enzymes.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of infection with Diplococcus pneumoniae on synthesis of ribonucleic acids in rat liver

Thompson

Wannemacher

1973

Biochemical Journal

View full text Add to dashboard Cite

Rats infected with virulent Diplococcus pneumoniae developed a significant increase in the rate of incorporation of labelled orotate into hepatic RNA when compared with pair-fed controls inoculated with heat-killed organisms. The finding was readily detected in rats raised on either a low-protein diet (6% casein) or a diet containing adequate amounts of protein (18% casein). The increase in hepatic RNA synthesis was observed by 12h and was maximal by 16-20h after inoculation with the D. pneumoniae. Most of the infection-related increase in RNA synthesis was associated with the bound ribosomal RNA fraction of the liver. A small but less significant increase was observed in the synthesis of free ribosomal RNA. The increased synthesis of RNA in the liver of infected rats resulted in a marked elevation of the liver RNA/DNA ratio, the major increase being observed in concentration of bound ribosomal RNA fraction. When followed sequentially, the infection-related increase in synthesis of hepatic RNA was preceded by a flux of amino acids into liver and was followed by elevated synthesis rates of serum globulin proteins. These findings suggest that the infectious process was able to regulate hepatic RNA synthesis by altering the rate of transcription of new RNA. This mechanism was stimulated even in rats that had been severely depleted of body protein and amino acids by feeding them on a low-protein diet. The infection-related stimulation of liver RNA and protein synthesis thus appeared to take place at the expense of other body proteins.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of infection with Diplococcus pneumoniae on synthesis of ribonucleic acids in rat liver

Thompson

Wannemacher

1973

Biochemical Journal

View full text Add to dashboard Cite

show abstract

“…Stimulation of tryptophan oxygenase activity has been noted during infection of mice with S. typhimurium or its endotoxin (1) , and pneumococci ( 2 ) . Stimulation of tryptophan oxygenase activity has been noted during infection of mice with S. typhimurium or its endotoxin (1) , and pneumococci ( 2 ) .…”

Section: 5mentioning

confidence: 99%