Host derived exosomes-pathogens interactions: Potential functions of exosomes in pathogen infection

Wang, Jianjun; Yao, Yongliang; Chen, Xiaomei; Wu, Jianhong; Gu, Tao; Tang, Xin

doi:10.1016/j.biopha.2018.09.174

Cited by 60 publications

(50 citation statements)

References 91 publications

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“…The novel 7-(ethoxycarbonyl)-8-(arylamino)- [1,3]dioxolo [4,5-g] quinolin-5-ium iodide derivatives were synthesized according to Scheme 1.…”

Section: Chemistrymentioning

confidence: 99%

“…Cancer and infections are the most serious problems that need to be solved. With the continuous improvement of human health requirements, research and development of new drugs has accelerated . The existing drugs are no longer sufficient for a variety of refractory diseases, which requires further improvement of longer‐term effective comprehensive drugs …”

Section: Introductionmentioning

confidence: 99%

“…With the continuous improvement of human health requirements, research and development of new drugs has accelerated. [1] The existing drugs are no longer sufficient for a variety of refractory diseases, which requires further improvement of longer-term effective comprehensive drugs. [2][3][4][5][6] Cancer is a disease that is difficult to cure; it exhibits abnormal metabolic processes in living organisms for a variety of reasons, mainly due to various features, [7][8][9][10] such as complexity, diversification, and continuity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

Jin

Xiao

et al. 2020

ChemMedChem

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A series of novel quinoline and quinolinium iodide derivatives were designed and synthesized to discover potential anticancer and antibacterial agents. With regard to anticancer properties, in vitro cytotoxicities against three human cancer cell lines (A‐549, HeLa and SGC‐7901) were evaluated. The antibacterial properties against two strains, Escherichia coli (ATCC 29213) and Staphylococcus aureus (ATCC 8739), along with minimum inhibitory concentration (MIC) values were evaluated. The target alkyliodine substituted compounds exhibited significant antitumor and antibacterial activity, of which compound 8‐((4‐(benzyloxy)phenyl)amino)‐7‐(ethoxycarbonyl)‐5‐propyl‐[1,3]dioxolo[4,5‐g]quinolin‐5‐ium (12) was found to be the most potent derivative with IC50 values of 4.45±0.88, 4.74±0.42, 14.54±1.96, and 32.12±3.66 against A‐549, HeLa, SGC‐7901, and L‐02 cells, respectively, stronger than the positive controls 5‐FU and MTX. Furthermore, compound 12 had the most potent bacterial inhibitory activity. The MIC of this compound against both E. coli and S. aureus was 3.125 nmol ⋅ mL−1, which was smaller than that against the reference agents amoxicillin and ciprofloxacin.

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“…The novel 7-(ethoxycarbonyl)-8-(arylamino)- [1,3]dioxolo [4,5-g] quinolin-5-ium iodide derivatives were synthesized according to Scheme 1.…”

Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

Jin

Xiao

et al. 2020

ChemMedChem

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“…Exosomes are flattened hemispheres surrounded by lipid bilayers, with a density of 1.13–1.21 g/mL, and a diameter of 30–100 nm. They are generally generated through the endosomal pathway . Exosomes can be found in different body fluids, such as plasma, saliva, urine, latex, cerebrospinal fluid, and ascites .…”

Section: Introductionmentioning

confidence: 99%

“…They are generally generated through the endosomal pathway. 6,7 Exosomes can be found in different body fluids, such as plasma, saliva, urine, latex, cerebrospinal fluid, and ascites. 8 Exosomes are packets of cellular proteins, lipids, RNA (miRNAs, mRNAs, lncRNA), and DNA released by cells into the extracellular space and enveloped by a portion of the cellular membrane.…”

Section: Introductionmentioning

confidence: 99%

Potential role of exosomes in cancer therapy

Zhao

Xie

2019

Precision Radiation Oncology

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Cancer is a major public health problem, and >18.1 million new cancer cases are diagnosed annually. Cancer can be treated with the help of several methods, such as surgery, chemotherapy, radiotherapy, and immunotherapy. Chemoresistance causes disease relapse and metastasis, and is a main obstacle to cancer therapy. The function of exosomes has been recently highlighted in cancer treatment and therapeutic resistance. Exosomes, described as nanovesicles secreted by multiple mammalian cell types, play important roles in intercellular communication by acting as carriers of functional contents, such as proteins, non‐coding RNA (miRNA, lncRNA), mRNAs, and lipids. In addition, exosomes might participate in cancer therapeutic resistance. The present review aimed to describe the function of exosomes in different types of cancer, with emphasis on their role in chemoresistance, hoping to provide novel insights on their implications in cancer therapy.

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Exosomes: Biogenesis, targeting, characterization and their potential as "Plug & Play" vaccine platforms

Dyball

Smales

2022

Biotechnology Journal

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Exosomes are typically characterized as spherical extracellular vesicles less than 150 nm in diameter that have been released into the extracellular environment via fusion of multivesicular bodies (MVBs) to the plasma membrane. Exosomes play a key role in cell‐cell communication, vary widely in their composition and potential cargo, and are reportedly involved in processes as diverse as angiogenesis, apoptosis, antigen presentation, inflammation, receptor‐mediated endocytosis, cell proliferation, and differentiation, and cell‐signaling. Exosomes can also act as biomarkers of health and disease and have enormous potential use as therapeutic agents. Despite this, the understanding of how exosome biogenesis can be utilized to generate exosomes carrying specific targets for particular therapeutic uses, their manufacture, detailed analytical characterization, and methods of application are yet to be fully harnessed. In this review, the author describes the current understanding of these areas of exosome biology from a biotechnology and bioprocessing aspect, but also highlight the challenges that remain to be overcome to fully harness the power of exosomes as therapeutic agents, with a particular focus on their use and application as vaccine platforms.

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Host derived exosomes-pathogens interactions: Potential functions of exosomes in pathogen infection

Cited by 60 publications

References 91 publications

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents

Potential role of exosomes in cancer therapy

Exosomes: Biogenesis, targeting, characterization and their potential as "Plug & Play" vaccine platforms

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