Host-derived CEACAM-laden vesicles engage enterotoxigenicE. colifor elimination and toxin neutralization
Alaullah Sheikh,
Debayan Ganguli,
Tim J. Vickers
et al.
Abstract:Enterotoxigenic Escherichia coli (ETEC) cause hundreds of millions of diarrheal illnesses annually ranging from mildly symptomatic cases to severe, life-threatening cholera-like diarrhea. Although ETEC are associated with long-term sequelae including malnutrition, the acute diarrheal illness is largely self-limited. Recent studies indicate that in addition to causing diarrhea, the ETEC heat-labile toxin (LT) modulates the expression of many genes in intestinal epithelia, including carcinoembryonic cell adhesio… Show more
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