Host defence peptides in human burns

Kaus, Aljoscha; Jacobsen, Frank; Sorkin, Michael; Rittig, A.; Voß, B.; Daigeler, Adrien; Sudhoff, Holger; Steinau, Hans-Ulrich; Steinstraesser, Lars

doi:10.1016/j.burns.2007.04.017

Cited by 28 publications

(17 citation statements)

References 45 publications

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“…In situ hybridization revealed the expression of hCAP-18/LL-37, hBD2, and hBD3 at the surface of burns that was independent of burn depth. However, the finding of higher host defense peptide gene expression rates does not correlate with the incidence of wound infection in burns (Kaus et al 2008), indicating that the modified LL-37 expression contributes to the healing response rather than effective prevention of bacterial infection. In vitro, human cathelicidin stimulates the migration of the human keratinocyte cell line HaCaT that involves changes in actin dynamics and is associated with augmented tyrosine phosphorylation of proteins involved in focal adhesion complexes, such as focal adhesion kinase and paxillin.…”

Section: Ll-37 Regulation Of Angiogenesis and Cell Growthmentioning

confidence: 83%

“…LL-37 induces wound healing, proliferation, and migration of airway epithelial cells, indicating that the peptide is likely involved in the regulation of tissue homeostasis in the airways (Shaykhiev et al 2005). Analysis of expression profiles of human epithelial host defense peptides in burned and unburned skin tissue samples showed higher mRNA levels in partial-thickness burns than in unburned tissue (Kaus et al 2008). In situ hybridization revealed the expression of hCAP-18/LL-37, hBD2, and hBD3 at the surface of burns that was independent of burn depth.…”

Section: Ll-37 Regulation Of Angiogenesis and Cell Growthmentioning

confidence: 99%

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Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Bucki

Leszczyńska

Namiot

et al. 2010

Arch. Immunol. Ther. Exp.

186

174

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The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 peptide is a potent killer of different microorganisms with the ability to prevent immunostimulatory effects of bacterial wall molecules such as lipopolysaccharide and can therefore protect against lethal endotoxemia. Additional reported activities of LL-37 include chemoattractant function, inhibition of neutrophil apoptosis, and stimulation of angiogenesis, tissue regeneration, and cytokine release (e.g. IL-8). Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D(3). At infection sites, the function of LL-37 can be inhibited by charge-driven interactions with DNA and F-actin released from dead neutrophils and other cells lysed as the result of inflammation. A better understanding of LL-37's biological properties is necessary for its possible therapeutic application for immunomodulatory purposes as well as in treating bacterial infection.

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Section: Ll-37 Regulation Of Angiogenesis and Cell Growthmentioning

confidence: 83%

Section: Ll-37 Regulation Of Angiogenesis and Cell Growthmentioning

confidence: 99%

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Bucki

Leszczyńska

Namiot

et al. 2010

Arch. Immunol. Ther. Exp.

186

174

View full text Add to dashboard Cite

show abstract

“…This might be due Table 1 Pluripotent activity of the human cathilicidin to the presence of more viable, thus traumatized cells, whereas in the center, cells are already dead (Kaus et al 2008). These combined data show that HDPs play a major role in wound healing and wound infection.…”

Section: Host Defense Peptides In Woundsmentioning

confidence: 97%

Host defense peptides and their antimicrobial-immunomodulatory duality

et al. 2011

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“…However, it became evident that in the edges of burn wounds a 10-fold reduction in LL-37 expression occurs. This might be due to the presence of more viable, traumatized cells, whereas in the center, cells are already dead (161). These combined data show that host defense peptides play a major role in wound healing and wound infection.…”

Section: Host Defense Peptides In Woundsmentioning

confidence: 76%

Host Defense Peptides in Wound Healing

Steinstraesser

Koehler

Jacobsen

et al. 2008

Mol Med

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144

112

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Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune response in infection and inflammation. These features make them of high interest for wound healing research. Nonhealing and infected wounds are a major problem in patient care and health care spending. Increasing infection rates, growing bacterial resistance to common antibiotics, and the lack of effective therapeutic options for the treatment of problematic wounds emphasize the need for new approaches in therapy and pathophysiologic understanding. This review focuses on the current knowledge of host defense peptides affecting wound healing and infection. We discuss the current data and highlight the potential future developments in this field of research.

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Host defence peptides in human burns

Cited by 28 publications

References 45 publications

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Host defense peptides and their antimicrobial-immunomodulatory duality

Host Defense Peptides in Wound Healing

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