Host CD3+ T-cells can significantly modulate phage treatment effects on bacterial bioburden in mouse models
Renhua Li,
Michael Rouse,
Brendon T. Pace
et al.
Abstract:Wound healing is a complex system including such key players as host, microbe, and treatments. However, little is known about their dynamic interactions. Here we explored the interplay between: (1) bacterial bioburden and host immune responses, (2) bacterial bioburden and wound size, and (3) treatments and wound size, using murine models and various treatment modalities: Phosphate buffer saline (PBS or vehicle, negative control), doxycycline, and two doses of A. baumannii phage mixtures. We uncovered that the … Show more
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