Hospitalized Nephrolithiasis after Renal Transplantation in the United States

Abstract

The national incidence of and risk factors for hospitalized nephrolithiasis (NEP) in renal transplant (RT) recipients has not been reported. We conducted a historical cohort study of 42 096 RT recipients in the United States Renal Data System between 1 July 1994 and 30 June 1998. The 1-year incidence of NEP (ICD-9 codes 592.x) after RT in 1997 was compared to the rate of NEP in the general population using the National Hospital Discharge Survey. Associations with time to hospitalizations for a primary diagnosis of nephrolithiasis were assessed by Cox Regression. NEP was uncommon after RT (104 cases per 100 000 person years in 1997). However, females, but not males, had a statistically significant increased risk of NEP compared to the general population (rate ratio for females, 2.84, 95% confidence interval, 2.35-3.58). Kidney stones were more common than ureteral stones, and percutaneous procedures were more common than ureteroscopy or extracorporeal shock wave lithotripsy (ESWL). The only risk factor identified for NEP was renal failure due to stone disease (only one case). NEP was uncommon after RT, but was still more common than in the general population. We identified differences in the presentation and management of NEP after RT in comparison to the general population.

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

“…In addition, UTI were rare and the authors suggested that LUTS and BPH were not clinically significant risk factors for UTI (16). However, the unique susceptibility of the transplanted kidney (denervation, reflux with abnormal ureteral valves, immunosuppression) may influence this situation similarly to posttransplant nephrolithiasis (24). Although we have demonstrated an independent association of BPH and AUR, UTI, and allograft loss, we cannot comment on the specific mechanism of graft loss.…”

Les complications chirurgicales de la transplantation rénale à partir du donneur vivant: expérience du CHU Ibn Sina de Rabat

“…Elle donne d'excellents résultats même si dans certains cas la néphrostomie est nécessaire pour éviter l'obstruction urétérale par les fragments lithiasiques [8]. La néphrolithotomie percutanée peut aussi être pratiquée [10,11]. L'urétéroscopie a également été utilisée [12,13].…”

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“…19,20 A metabolic change in the serum and urine of the renal transplant recipient may be a favoring factor for stone development. Hyperparathyroidism, lower citraturia, 9 higher oxaluria, 21 excessive alkaline urine pH, 19 and cyclosporine-induced hyperuricosuria 22 are contributing factors to different types of stone development, namely, calcium oxalate, calcium phosphate, and uric acid stones.…”