Hospitalization Time and Outcome in Patients with Coronavirus Disease 2019 (COVID-19): Analysis Data from China

Chai, Songshan; Xiao, Dongdong; Cheng, Qikai; Huang, Shengzhi; Wang, Yihao; Qian, Jiajia; Wang, Jiajing; Jun-jun, LI; Fu, Peng; Wang, Qiangping; Rao, Jingyi; Zhao, Hongyang; Zhang, Fangcheng; Xiong, Nanxiang

doi:10.2139/ssrn.3572888

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“…The estimated median of 16.2 days from symptom onset to hospital discharge among COVID-19 patients was comparable to that for MERS (12-20 days) but shorter than for SARS (29.7 days) [18,39,[52][53][54]. Our estimate is shorter than two recent estimates (mean durations of 19.4 and 24.7 days) for COVID-19 [55,56]. Our study indicated that the recovery of paediatric cases could be faster than of elderly patients, probably because they have mild symptoms, but this observation needs to be confirmed by future studies with more paediatric cases [20].…”

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confidence: 42%

Epidemiological parameters of COVID-19 and its implication for infectivity among patients in China, 1 January to 11 February 2020

et al. 2020

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Background: The natural history of disease in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remained obscure during the early pandemic. Aim: Our objective was to estimate epidemiological parameters of coronavirus disease (COVID-19) and assess the relative infectivity of the incubation period. Methods: We estimated the distributions of four epidemiological parameters of SARS-CoV-2 transmission using a large database of COVID-19 cases and potential transmission pairs of cases, and assessed their heterogeneity by demographics, epidemic phase and geographical region. We further calculated the time of peak infectivity and quantified the proportion of secondary infections during the incubation period. Results: The median incubation period was 7.2 (95% confidence interval (CI): 6.9-7.5) days. The median serial and generation intervals were similar, 4.7 (95% CI: 4.2-5.3) and 4.6 (95% CI: 4.2-5.1) days, respectively. Paediatric cases < 18 years had a longer incubation period than adult age groups (p = 0.007). The median incubation period increased from 4.4 days before 25 January to 11.5 days after 31 January (p < 0.001), whereas the median serial (generation) interval contracted from 5.9 (4.8) days before 25 January to 3.4 (3.7) days after. The median time from symptom onset to discharge was also shortened from 18.3 before 22 January to 14.1 days after. Peak infectivity occurred 1 day before symptom onset on average, and the incubation period accounted for 70% of transmission. Conclusion: The high infectivity during the incubation period led to short generation and serial intervals, necessitating aggressive control measures such as early case finding and quarantine of close contacts.

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