Hospitalization Requiring Intensive Care Unit Due to SARS-CoV-2 Infection Correlated With IgM Depression and IgG Elevation

Abstract

Aim: This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine wards. Materials & methods: The authors retrospectively reviewed 113 hospitalized patients with COVID-19. They assessed antibody response against five SARS-CoV-2 epitopes at 6–14 days post symptom onset in these patients. Results: Patients with ICU admissions had decreased anti-nucleocapsid immunoglobulin (Ig)M and increased anti-spike IgG compared with patients not requiring the ICU. IgG levels were positively correlated with length of stay. Conclusion: Higher levels of IgG against the spike protein correlate with COVID-19 disease severity and length of stay in hospitalized patients. This adds to the knowledge of biochemical response to clinical disease and may help predict ICU needs.

Validation of N Protein Antibodies to Diagnose Previous SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers: Use of Roche Elecsys® Immunoassay in the S Protein Vaccination Era

“…The tests provide accurate diagnosis if performed on specimens collected 10 to 14 days after symptom onset, but performance varies among methods [9,13]. Different studies relate antibody titers after SARS-CoV-2 infection with age, sex, and severity [18][19][20][21]. More than 350 vaccines are currently being investigated for a potential role in mitigating the COVID-19 pandemic (https://www.who.int/publications/m/item/draft-landscapeof-COVID-19-candidate-vaccines, accessed on 27 February 2023).…”