Hospitalization Frequency and Charges for Neurocysticercosis, United States, 2003–2012

O’Neal, Seth E.; Flecker, Robert H.

doi:10.3201/eid2106.141324

Cited by 93 publications

(48 citation statements)

References 19 publications

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“…Cysticercosis is also increasingly diagnosed in industrialized countries, mainly due to migration from endemic areas, with approximately 2 000 new cases diagnosed in the United States each year [3, 4]. In endemic countries, nearly 30% of neurologic seizures are attributable to NCC [5].…”

Section: Neurocysticercosis: a Leading Cause Of Seizures Worldwidementioning

confidence: 99%

Disease Centered Around Calcified Taenia solium Granuloma

Nash

Bustos²,

Garcı́a

2017

Trends in Parasitology

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Taenia solium (the pork tapeworm) is present in most developing countries, where it is a frequent cause of seizures and other neurological disease. Parasitic larvae invade the human brain, establish, and eventually resolve, leaving a calcified scar. While these lesions are common in endemic regions and most of these are clinically silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions and in from 30–65% of the time associated with perilesional edema, likely due to host inflammation. This manuscript summarizes the importance, characteristics, natural history and potential prevention and treatments of symptomatic calcified neurocysticercosis.

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Section: Neurocysticercosis: a Leading Cause Of Seizures Worldwidementioning

confidence: 99%

Disease Centered Around Calcified Taenia solium Granuloma

Nash

Bustos²,

Garcı́a

2017

Trends in Parasitology

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“…NCC is the most common cause of acquired adult epilepsy worldwide 4, 7, 8, 9, 10, 11, 12, 13. Epilepsy due to NCC can lead to severe health consequences as seizures are associated with an increased risk of sudden death14, 15, 16, 17 and 20–30% of NCC patients with epilepsy continue to have seizures despite treatment 9…”

Section: Introductionmentioning

confidence: 99%

Inflammation is a key risk factor for persistent seizures in neurocysticercosis

Herrick

Maharathi

Kim

et al. 2018

Ann Clin Transl Neurol

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ObjectiveWe conducted a retrospective, case–control study of neurocysticercosis patients to ascertain early markers that identify subjects likely to develop treatment‐resistant seizures.MethodsClinical histories and imaging studies from 38 neurocysticercosis patients who had been followed for 18 months after treatment were evaluated. Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures.ResultsEleven of 38 patients continued to have seizures during the follow‐up period. On univariate analysis, the number of neurocysticercosis lesions, number of bands on the baseline neurocysticercosis western blot, edema volumes on follow‐up MRI scans, edema volume changes between baseline and follow‐up images, and proportion of calcified lesions with perilesional edema were all significantly increased in subjects who had persistent seizures during the 18‐month follow‐up period. On multivariate analyses using recursive partition and random forest algorithms, variables associated with persistent seizures included: the number of total and calcified lesions, presence of perilesional edema, the rate of change in the lesion and edema volumes from baseline to follow‐up, and the number of bands on the neurocysticercosis western blot.InterpretationMeasures of both inflammation and disease burden are key risk factors for persistent seizures despite anticonvulsant treatments in patients with neurocysticercosis. Inflammation is therefore a potentially modifiable risk factor for the frequently seen severe seizure disorders in patients with neurocysticercosis.

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“…Most epidemiologic studies, therefore, use hospital-discharge datasets, which capture inpatient cases only ( 3 – 9 ). The results of our study show that twice as many neurocysticercosis cases are found when inpatient and outpatient data are searched than when only inpatient data are searched.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, neurocysticercosis is increasingly identified in migrants and travelers from nonindustrialized countries, particularly among the Hispanic population ( 2 ). However, because no reliable surveillance system for neurocysticercosis exists, studies to document the frequency of the disease have relied primarily on hospital discharge data ( 3 – 9 ). These studies may underestimate the frequency of neurocysticercosis and provide a biased representation of its effects.…”

mentioning

confidence: 99%