Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy

Adelöw, Cecilia; Andersson, Tomas; Ahlbom, Anders; Tomson, Torbjörn

doi:10.1212/wnl.0b013e318245f461

Cited by 167 publications

(121 citation statements)

References 48 publications

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“…Considering the bipolar disorder NOS presentation of our patient and data in the literature on links between epilepsy and bipolar disorder,24, 25, 26 we suggest there may be a link between resistant epileptic disease and bipolar disorder NOS in R(20). Therefore, we extrapolate that bipolar disorder features could be triggered or exacerbated by status epilepticus.…”

Section: Discussionmentioning

confidence: 63%

Lithium improved behavioral and epileptic symptoms in an adolescent with ring chromosome 20 and bipolar disorder not otherwise specified

Inal

Chaumette

Soleimani

et al. 2018

Clinical Case Reports

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Section: Discussionmentioning

confidence: 63%

Lithium improved behavioral and epileptic symptoms in an adolescent with ring chromosome 20 and bipolar disorder not otherwise specified

Inal

Chaumette

Soleimani

et al. 2018

Clinical Case Reports

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show abstract

“…The predisposition of patients with psychiatric complications for seizures and of patients with epilepsy to develop behavioral complications are both well documented (Adelöw et al, 2012;Forsgren and Nystrom, 1999;Hesdorffer et al, 2012). Although data favors the hypothesis that epilepsy and its behavioral comorbidities have a common underlying mechanism, and that morphological, biochemical, and behavioral changes caused by one disorder may provoke another, the exact pathogenesis of behavioral comorbidities in epilepsy remains obscure, and there is a lack of standard screening and treatment approaches (Ott et al, 2003).…”

Section: Melatonin and Depression/anxiety Comorbidities In Epilepsymentioning

confidence: 99%

The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Tchekalarova

Moyanova

Fusco

et al. 2015

Brain Research Bulletin

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Abstract\ud \ud There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle

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“…Yet, in people with epilepsy (PWE), data from epidemiologic studies have shown a higher prevalence of primary psychiatric disorders preceding the onset of the seizure disorder than in the general population [1][2][3][4][5][6]. In addition, in animal models of depression, rapid amygdala kindling was achieved more rapidly when the animal was subjected to conditions of great stress [7].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

Kanner

Mazarati

Koepp³

2014

Neurotherapeutics

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The last decade has witnessed a significant shift on our understanding of the relationship between psychiatric disorders and epilepsy. While traditionally psychiatric disorders were considered as a complication of the underlying seizure disorder, new epidemiologic data, supported by clinical and experimental research, have suggested the existence of a bidirectional relation between the two types of conditions: not only are patients with epilepsy at greater risk of experiencing a psychiatric disorder, but patients with primary psychiatric disorders are at greater risk of developing epilepsy. Do these data suggest that some of the pathogenic mechanisms operant in psychiatric comorbidities play a role in epileptogenesis? The aim of this article is to review the epidemiologic data that demonstrate that primary psychiatric disorders are more frequent in people who develop epilepsy, before the onset of the seizure disorder than among controls. The next question looks at the available data of pathogenic mechanisms of primary mood disorders and their potential for facilitating the development and/or exacerbation in the severity of epileptic seizures. Finally, we review data derived from experimental studies in animal models of depression and epilepsy that support a potential role of pathogenic mechanisms of mood disorders in the development of epileptic seizures and epileptogenesis. The data presented in this article do not yet establish conclusive evidence of a pathogenic role of psychiatric comorbidities in epileptogenesis, but raise important research questions that need to be investigated in experimental, clinical, and population-based epidemiologic research studies.

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Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy

Abstract: The increased rate of psychiatric comorbidity predating and succeeding seizure onset indicates a bidirectional relationship and common underlying mechanisms for psychiatric disorders and epilepsy.

Cited by 167 publications

References 48 publications

Lithium improved behavioral and epileptic symptoms in an adolescent with ring chromosome 20 and bipolar disorder not otherwise specified

Lithium improved behavioral and epileptic symptoms in an adolescent with ring chromosome 20 and bipolar disorder not otherwise specified

The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

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