Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China

Lin, Jiangtao; Xing, Bin; Tang, Huaping; Yang, Lan; Yuan, Yadong; Gu, Yuanyuan; Chen, Ping; Liu, Xiaoju; Zhang, Jie; Liu, Huiguo; Wang, Changzheng; Zhou, Wei; Sun, Dejun; Chen, Yiqiang; Chen, Zhuochang; Huang, Mao; Lin, Qi‐Chang; Hu, Chengping; Yang, Xiuwen; Huo, Jianmin; Ye, Xianwei; Zhou, Xin; Jiang, Ping; Zhang, Wei; Huang, Yijiang; Dai, L M; Liu, Rong‐Yu; Cai, Shaoxi; Xu, Jun‐Fa; Zhou, Jianying

doi:10.4168/aair.2020.12.3.485

Cited by 18 publications

(19 citation statements)

References 19 publications

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“…Due to the continuous improvement of China's health insurance policy, we found that the nancial burden of asthma patients is signi cantly lower than that of developed countries such as the United States. Similar results were obtained from several related studies in mainland China [23,24]. A study found that the annual per-person incremental medical cost of asthma in the United States was $3,266, of which $1,830 was attributable to prescription medication, $640 to o ce visits, $529 to hospitalizations, $176 to hospital-based outpatient visits, and $105 to emergency room visits in 2015 [25].…”

Section: Discussionsupporting

confidence: 82%

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study

Shang

et al. 2021

Preprint

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Background: Asthma is a common chronic airway inflammation that produces a healthcare burden on the economy.Objective: To obtain a better understanding of the clinical status and disease burden of patients with asthma in China. Methods: A retrospective study based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (n = 31,082) was carried out. The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to GINA 2018. Results: The results revealed that the majority (75.0%) of patients suffered from mild asthma. Patients treated with ICS/LABA at emergency department visits had lower frequencies of exacerbations in the following year compared with non-ICS/LABA treated patients.The incidence rates for 1 exacerbation are 14.49% vs 15.01 for the patients treated with ICS/LABA and without. The rates are 11.94% and 19.12% for 2 exacerbations above. The numbers are 6.51% vs 12.92% for 3 exacerbations above. The rates are 4.10% vs 9.35% for 4 exacerbations above. Also the difference got the statistical significance (p <0.001), COPD and GRED, two comorbidities related to asthma, were risk factors for asthma exacerbation. Finally, patients who suffered from exacerbations produced a heavier economic burden compared to the patients who never suffered exacerbations(mean costs are ￥3,339.67 vs ￥968.45 separately). Conclusions: These results provide a reference for clinicians and patients to obtain a better treatment and therapy strategy management for asthma sufferers.

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Section: Discussionsupporting

confidence: 82%

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study

Shang

et al. 2021

Preprint

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Section: Resultsmentioning

confidence: 99%

Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics

et al. 2022

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Background Asthma exacerbation threatens patient's life. Several genetic studies have been conducted to determine the risk factors for asthma exacerbation, but this information is still lacking. We aimed to determine whether genetic variants of Oxidative Stress Responsive Kinase 1 (OXSR1), a gene with functions of salt transport, immune response, and oxidative stress, are associated with exacerbation of asthma. Methods Clinical data were obtained from 1454 asthmatics and single nucleotide polymorphisms (SNPs) of OXSR1 were genotyped. Genetic associations with annual exacerbation rate were analyzed depending on smoking status. Results Eleven SNPs were selected using Asian data in the International HapMap database. The common allele of rs1384006 C > T of OXSR1 showed a significantly higher annual exacerbation rate than the rare allele in non-smoking asthmatics (CC vs. CT vs. TT: 0.43 ± 0.04 vs. 0.28 ± 0.03 vs. 0.31 ± 0.09, P = 0.004, Pcorr = 0.039). The frequent exacerbators had a significantly higher frequency of the common allele of rs1384006 C > T than did the infrequent exacerbators (74.4% vs. 55.2%, P = 0.004, Pcorr = 0.038). Conclusion The common allele of rs1384006 C > T of OXSR1 was associated with the asthma exacerbation rate and a higher risk of being a frequent exacerbator, indicating that non-smoking asthmatics who carry common alleles may be vulnerable to asthma exacerbations.

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“…The reason for this nding could be explained by smoking itself being a strong inducer to exacerbate asthma. [32] Cigarette smoking is associated with accelerated decline of lung function in asthmatics, [46] resulting in worsening of asthma severity, [47] reduction of responsiveness to glucocorticoids, [48] poor asthma control, and a higher hospital admissions. [49] The most important mechanism that may explain the relative corticosteroid resistance in smokers with asthma and COPD is a reduction in the expression of the enzyme histone deacetylase 2 (HDAC2).…”

Section: Discussionmentioning

confidence: 99%

“…In non-smokers, we performed analyses on each group of never-smokers (NS = 955) and current and ex-smokers (n = 499), because smoking itself is a confounding variable affecting asthma exacerbations. [32] Clinical parameters of the two groups are presented in supplement Table 3. In the analysis using the univariate general linear model, rs9839010, rs1392283, rs74919163, rs1384006, rs2011, ht1c, ht4c, and ht2 in block1 showed differences (P < 0.05) in the annual number of exacerbations depending on the genotypes in the non-smoker group (Table 2).…”

Section: Association Of Snps and Haplotypes On Oxsr1 With Annual Numbmentioning

confidence: 99%

Association of Genetic Variants of Oxidative Stress Responsive Kinase 1 (OXSR1) with Asthma Exacerbations in Non-Smoking Asthmatics

Kim1

Chang

Lee

et al. 2021

Preprint

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Background: Asthma exacerbation threatens patient's life. Several genetic studies have been conducted to determine the risk factors for asthma exacerbation, but this information is still lacking. We aimed to determine whether genetic variants of Oxidative Stress Responsive Kinase 1(OXSR1), a gene with functions of salt transport, immune response, and oxidative stress, are associated with exacerbation of asthma.Methods: Clinical data were obtained from 1,454 asthmatics and single nucleotide polymorphisms (SNPs) of OXSR1 were genotyped. Genetic associations with annual exacerbation rate were analyzed depending on smoking status. Results: Eleven SNPs were selected using Asian data in the International HapMap database. The common allele of rs1384006 C>T of OXSR1 showed a significantly higher annual exacerbation rate than the rare allele in non-smoking asthmatics (CC vs. CT vs. TT: 0.43 ± 0.04 vs. 0.28 ± 0.03 vs. 0.31 ± 0.09, P=0.004, Pcorr=0.039). The frequent exacerbators had a significantly higher frequency of the common allele of rs1384006 C>T than did the infrequent exacerbators (74.4% vs. 55.2%, P=0.004, P corr=0.038). Conclusion: The common allele of rs1384006 C>T of OXSR1 was associated with the asthma exacerbation rate and a higher risk of being a frequent exacerbator, indicating that non-smoking asthmatics who carry common alleles may be vulnerable to asthma exacerbations.

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Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China

Cited by 18 publications

References 19 publications

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study

Clinical Characteristics and Economic Burden of Asthma in China: A Multicenter Retrospective Study

Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics

Association of Genetic Variants of Oxidative Stress Responsive Kinase 1 (OXSR1) with Asthma Exacerbations in Non-Smoking Asthmatics

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