Hospitalization Costs for Heart Failure in People with Type 2 Diabetes: Cost-Effectiveness of its Prevention Measured by a Simulated Preventive Treatment

Caporale, Joaquín; Elgart, Jorge Federico; Pfirter, G; Martínez, Pablo Moya; Viñes, Gloria; Insúa, Jorge T.; Gagliardino, Juan José

doi:10.1016/j.jval.2011.05.018

Cited by 9 publications

(8 citation statements)

References 17 publications

(29 reference statements)

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“…Studies investigating the prevalence of diabetes mellitus are unanimous to show that this is much bigger in people aged over 40 years. (3,15) When analyzed separately by gender, it is observed that the rates for women remained higher throughout the period studied, confirming findings of another study (15) that investigated the hospitalizations for diabetes mellitus, which also found female prevalence. The prevalence of women hospitalizations reflects the higher prevalence of the disease in this gender.…”

Section: Discussionsupporting

confidence: 75%

Tendência de hospitalizações por diabetes mellitus: implicações para o cuidado em saúde

et al. 2015

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Objective: To analyze the trend in hospitalizations for diabetes mellitus in a period of 15 years, according to gender and age group. Methods: Descriptive study, with time series data from hospitalization for diabetes mellitus in individuals of both genders, aged 20 or more, data obtained in the information system of the unified health system and analyzed according to descriptive statistics and polynomial regression. Results: A total of 117,717 hospitalizations were registered, 61.6% were women. The general trend was stable, although it has been increasing for men (r²=0.83; p<0.001) and stable for women. Age group 50 -59 and older than 80 years (r²=0.78; p<0.001 for both) showed increasing trend for men, while for all ages it was stable or it was declining for women. Conclusion: The trend in hospitalization for diabetes mellitus stratified by gender and age was increasing just for men in the age group of 50 -59 years and older than 80 years. ResumoObjetivo: Analisar a tendência de hospitalizações por diabetes mellitus em um período de 15 anos, segundo sexo e faixa etária. Métodos: Estudo descritivo, de séries temporais com dados de hospitalização por diabetes mellitus em indivíduos de ambos os sexos, com 20 ou mais anos, obtidos no sistema de informações do sistema único de saúde e analisados segundo estatística descritiva e regressão polinomial. Resultados: Foram registradas 117.717 hospitalizações, sendo 61,6% de mulheres. A tendência geral foi de estabilidade, embora tenha sido crescente para os homens (r²=0,83; p<0,001) e estável para mulheres. As faixas etárias de 50 a 59 e maiores de 80 anos (r²=0,78; p<0,001 ambos) apresentaram tendência crescente para homens, enquanto para todas as idades houve estabilidade ou em declínio para mulheres. Conclusão: A tendência de hospitalização por diabetes mellitus estratificada por sexo e idade, foi crescente apenas para homens entre 50 a 59 anos e maiores de 80 anos.

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Section: Discussionsupporting

confidence: 75%

Tendência de hospitalizações por diabetes mellitus: implicações para o cuidado em saúde

et al. 2015

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“… 9 , 10 , 16 , 30 – 49 Three economic sub-studies of multicountry RCT populations also included US samples. 50 – 52 One Argentinian hospital cohort, 53 a Canadian hospital cohort, 54 and a Thai hospital cohort 55 are the only studies with cost estimates outside the US.…”

Section: Resultsmentioning

confidence: 99%

“…The average cost of an acute heart failure hospitalization across all studies was $11,686 (median: $10,291). Costs ranged from $529 in the Argentinian hospital cohort 53 to $27,006 in a US claims analysis of patients aged 18–64 years. 43 Acute costs for diabetics were found in one US claims analysis ($12,757).…”

Section: Resultsmentioning

confidence: 99%

Patient-level costs of major cardiovascular conditions: a review of the international literature

Nicholson¹,

Gandra

Halbert³

et al. 2016

CEOR

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ObjectiveRobust cost estimates of cardiovascular (CV) events are required for assessing health care interventions aimed at reducing the economic burden of major adverse CV events. This review synthesizes international cost estimates of CV events.MethodsMEDLINE database was searched electronically for English language studies published during 2007–2012, with cost estimates for CV events of interest – unstable angina, myocardial infarction, heart failure, stroke, and CV revascularization. Included studies provided at least one estimate of patient-level direct costs in adults for any identified country. Information on study characteristics and cost estimates were collected. All costs were adjusted for inflation to 2013 values.ResultsAcross the 114 studies included, the average cost was US $6,466 for unstable angina, $11,664 for acute myocardial infarction, $11,686 for acute heart failure, $11,635 for acute ischemic stroke, $37,611 for coronary artery bypass graft, and $13,501 for percutaneous coronary intervention. The ranges for cost estimates varied widely across countries with US cost estimate being at least twice as high as European Union costs for some conditions. Few studies were found on populations outside the US and European Union.ConclusionThis review showed wide variation in the cost of CV events within and across countries, while showcasing the continuing economic burden of CV disease. The variability in costs was primarily attributable to differences in study population, costing methodologies, and reporting differences. Reliable cost estimates for assessing economic value of interventions in CV disease are needed.

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“…Data from observational studies suggest that the degree of glycaemia is directly associated with the risk of CHF ,. This association is of clinical importance since, if causal, it implies that better glycaemic control can contribute to preventing CHF in people with diabetes . However, considerable uncertainty exists, and the magnitude of the risk has not been described in sufficient detail.…”

Section: Introductionmentioning

confidence: 99%

Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus: systematic review and meta‐analysis

Erqou

Lee

Suffoletto

et al. 2013

European J of Heart Fail

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BackgroundClinical trials to date have not provided definitive evidence regarding the effects of glucose lowering on the incidence of congestive heart failure (CHF). We synthesized available prospective epidemiological data on the association between glycaemia measured by haemoglobin A 1c (HbA 1c ) and incident CHF in individuals with diabetes. Methods and resultsWe searched electronic databases and reference lists of selected articles for relevant prospective epidemiological studies. We abstracted data from relevant studies using standardized forms and obtained additional data from investigators when required. We pooled study-specific relative risk estimates using random-effects model meta-analysis.Of the 1044 citations identified, we included 10 studies comprising 178 929 participants with diabetes and 14 176 incident CHF cases. Five studies included only patients with type 2 diabetes, four studies had predominantly patients with type 2 diabetes, and one study included only patients with type 1 diabetes. All studies except one showed an increased risk of CHF with higher HbA 1c . The overall adjusted risk ratio (RR) for CHF was 1.15 [95% confidence interval (CI) 1.10-1.21] for each percentage point higher HbA 1c . There was substantial heterogeneity across the 10 studies (I 2 : 83%; 95% CI 69 -91%; P , 0.001) not explained by available study-level characteristics such as study design or average HbA 1c level. In seven studies reporting RRs with more than one degree of adjustment, the association was minimally altered after adjustment for several cardiovascular risk factors. ConclusionsIn observational studies of individuals with diabetes, a higher HbA 1c level was associated with a significantly increased incidence of CHF.--

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Hospitalization Costs for Heart Failure in People with Type 2 Diabetes: Cost-Effectiveness of its Prevention Measured by a Simulated Preventive Treatment

Abstract: HbA1c control to reduce the number of HF events would be economically beneficial for health care payers.

Cited by 9 publications

References 17 publications

Tendência de hospitalizações por diabetes mellitus: implicações para o cuidado em saúde

Tendência de hospitalizações por diabetes mellitus: implicações para o cuidado em saúde

Patient-level costs of major cardiovascular conditions: a review of the international literature

Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus: systematic review and meta‐analysis

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