Hospitalization and mortality outcomes in the first 5 years after a childhood cancer diagnosis: a population-based study

Steineck, Angela; Chow, Eric J.; Doody, David R.; Mueller, Beth A.

doi:10.1007/s10552-021-01425-1

Cited by 3 publications

(8 citation statements)

References 65 publications

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“…Previous studies 18,21,31,32 also identified increased injury among childhood cancer survivors relative to children without cancer. Injury outcomes are difficult to understand in these studies because this outcome category is usually heterogeneous, including trauma, poisoning, and burns as well as fractures potentially associated with cancer treatment-related bone density reduction.…”

Section: Jama Network Open | Oncologymentioning

confidence: 85%

“… 18 , 20 , 21 Increased short- and long-term hospitalization and mortality among childhood cancer survivors relative to children without cancer have been reported. 18 , 21 However, an important gap remains in our understanding of the role of race and ethnicity in outcomes among long-term survivors. This gap exists largely because hospitalization and mortality data for children with cancer are largely informed only by clinical trials.…”

Section: Introductionmentioning

confidence: 99%

“…Factors associated with survival disparity may include socioeconomic status, 10,11 access to treatment, 12 and co-occurrence of other health-related conditions, such as cardiovascular health, injury, and mental health factors. [13][14][15] Survivors of childhood cancer experience more hospitalizations than those without cancer, [16][17][18] with some hospitalizations related to cancer treatment 19 and others related to posttreatment factors. 18,20,21 Increased short-and long-term hospitalization and mortality among childhood cancer survivors relative to children without cancer have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Survivors of childhood cancer experience more hospitalizations than those without cancer, [16][17][18] with some hospitalizations related to cancer treatment 19 and others related to posttreatment factors. 18,20,21 Increased short-and long-term hospitalization and mortality among childhood cancer survivors relative to children without cancer have been reported. 18,21 However, an important gap remains in our understanding of the role of race and ethnicity in outcomes among long-term survivors.…”

Section: Introductionmentioning

confidence: 99%

“…Survivors of childhood cancer experience more hospitalizations than those without cancer, with some hospitalizations related to cancer treatment and others related to posttreatment factors . Increased short- and long-term hospitalization and mortality among childhood cancer survivors relative to children without cancer have been reported .…”

Section: Introductionmentioning

confidence: 99%

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Hospitalization and Mortality Outcomes Among Childhood Cancer Survivors by Race, Ethnicity, and Time Since Diagnosis

et al. 2022

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IMPORTANCECancer outcomes are relatively poor in adults who belong to minoritized racial and ethnic groups. Survival and long-term outcomes by race and ethnicity in individuals with childhood cancers are less studied. OBJECTIVE To evaluate survival and hospitalization among American Indian and Alaska Native, Asian, Black, and Hispanic children compared with non-Hispanic White children with cancer. DESIGN, SETTING, AND PARTICIPANTS This cohort study evaluated all individuals born in Washington State who were younger than 20 years (hereafter referred to as children) and had been diagnosed with cancer during 1987 to 2012, with follow-up ranging from 1 to 27 years. The data subset was built in 2019, and statistical analyses were completed in January 2022. EXPOSURES Race and ethnicity. MAIN OUTCOMES AND MEASURES Mortality and hospitalization events for all other racial and ethnic groups relative to non-Hispanic White children estimated by Cox proportional hazards regressions for the first 5 years after diagnosis and among cancer survivors 5 or more years after diagnosis.

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Section: Jama Network Open | Oncologymentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hospitalization and Mortality Outcomes Among Childhood Cancer Survivors by Race, Ethnicity, and Time Since Diagnosis

et al. 2022

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In Memoriam: Janet R. Daling, 1934–2022

Weiss

Madeleine

et al. 2023

American Journal of Epidemiology

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Investigating the safety and feasibility of osteopathic manipulative medicine in hospitalized children and adolescent young adults with cancer

Belsky,

Brown

2024

Journal of Osteopathic Medicine

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Context Children and adolescents young adults (AYAs) undergoing treatment for oncologic diagnoses are frequently hospitalized and experience unwanted therapy-induced side effects that diminish quality of life. Osteopathic manipulative treatment (OMT) is a medical intervention that utilizes manual techniques to diagnose and treat body structures. Few studies have investigated the implementation of OMT in the pediatric oncology outpatient setting. To date, no studies have investigated the safety and feasibility of OMT in the pediatric oncology inpatient setting. Objectives The objective of this study is to investigate the safety and feasibility of OMT in the pediatric oncology inpatient setting. Methods This is a prospective, single-institution pilot study evaluating children and AYAs aged ≥2 years to ≤30 years with a diagnosis of cancer hospitalized at Riley Hospital for Children (RH) from September 2022 to July 2023. Approval was obtained from the Indiana University Institutional Review Board (IRB). Patients were evaluated daily with a history and physical examination as part of routine inpatient management. Patients who reported chemotherapy side effects commonly encountered and managed in the inpatient setting, such as pain, headache, neuropathy, constipation, or nausea, were offered OMT. Patients provided written informed consent/assent prior to receiving OMT. OMT was provided by trained osteopathic medical students under the supervision of a board-certified osteopathic physician and included techniques commonly taught in first- and second-year osteopathic medical school curricula. Safety was assessed by a validated pain (FACES) scale immediately pre/post-OMT and by adverse event grading per Common Terminology Criteria for Adverse Events (CTCAE) 24 h post-OMT. All data were summarized utilizing descriptive statistics. Results A total of 11 patients were screened for eligibility. All patients met the eligibility criteria and were enrolled in the study. The majority of patients were male (n=7, 63.6 %) with a median age of 18.2 years at time of enrollment (range, 10.2–29.8 years). Patients had a variety of hematologic malignancies including B-cell acute lymphoblastic leukemia (ALL) (n=5, 45.5 %), T-cell ALL (n=1, 9.1 %), acute myeloid leukemia (AML) (n=2, 18.2 %), non-Hodgkin’s lymphoma (n=2, 18.2 %), and Hodgkin’s lymphoma (n=1, 9.1 %). All patients were actively undergoing cancer-directed therapy at the time of enrollment. There were 40 unique reasons for OMT reported and treated across 37 encounters, including musculoskeletal pain (n=23, 57.5 %), edema (n=7, 17.5 %), headache (n=5, 12.5 %), peripheral neuropathy (n=2, 5.0 %), constipation (n=2, 5.0 %), and epigastric pain not otherwise specified (n=1, 2.5 %). Validated FACES pain scores were reported in 27 encounters. Of the 10 encounters for which FACES pain scores were not reported, 8 encounters addressed lower extremity edema, 1 encounter addressed peripheral neuropathy, and 1 encounter addressed constipation. The total time of OMT was documented for 33 of the 37 encounters and averaged 9.8 min (range, 3–20 min). Conclusions Hospitalized children and AYAs with cancer received OMT safely with decreased pain in their reported somatic dysfunction(s). These findings support further investigation into the safety, feasibility, and efficacy of implementing OMT in the pediatric oncology inpatient setting and to a broader inpatient pediatric oncology population.

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Hospitalization and mortality outcomes in the first 5 years after a childhood cancer diagnosis: a population-based study

Cited by 3 publications

References 65 publications

Hospitalization and Mortality Outcomes Among Childhood Cancer Survivors by Race, Ethnicity, and Time Since Diagnosis

Hospitalization and Mortality Outcomes Among Childhood Cancer Survivors by Race, Ethnicity, and Time Since Diagnosis

In Memoriam: Janet R. Daling, 1934–2022

Investigating the safety and feasibility of osteopathic manipulative medicine in hospitalized children and adolescent young adults with cancer

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