Hospital-treated prevalent infections, the plasma proteome and incident dementia among UK older adults

A Systematic Review of the Neuroprotective Role and Biomarker Potential of GDF15 in Neurodegeneration

“…This highlights a critical need for biomarker studies to either utilise assays that specifically accommodate for this H6D variant or incorporate suitable statistical models to address variability. Furthermore, the use of prospective cohorts in some studies posed challenges in distinguishing GDF15-related disease risk directly associated with neurodegeneration as opposed to risks associated with all-cause mortality (Moon et al, 2020), infection (Beydoun et al, 2023) or cardiovascular disease (Wollert et al, 2017). Notably, certain studies lost significance when adjusting for cardiovascular risk factors (McGrath et al, 2020, Andersson et al, 2015, indicating that cardiovascular outcomes may play a significant role in driving this relationship.…”