Hospital resource utilization in a national cohort of functionally single ventricle patients undergoing surgical treatment

Dorobantu, Dan Mihai; Hu, Qi; Pujol, Ferran Espuny; Brown, Kate; Franklin, Rodney C. G.; Pufulete, Maria; Lawlor, Deborah A; Crowe, Sonya; Pagel, Christina; Stoica, Șerban

doi:10.1016/j.xjon.2023.03.014

Cited by 2 publications

(2 citation statements)

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“…Prematurity has also been demonstrated in larger studies to be a factor that significantly contributes to fewer days alive and out of hospital in the first year of life. 25 Overall, this analysis highlights important factors to consider when thinking about the prognosis of these patients and their days alive and out of hospital in the first year of life.…”

Section: Discussionmentioning

confidence: 99%

“…Other risk factors that reached significance in our model such as moderate-to-severe dominant atrioventricular valve regurgitation at birth, right ventricular dominance, and low birth weight all behave similarly to other studies of risk factors for survival or prolonged hospitalisations within the single-ventricle subgroups. [22][23][24][25] While these well-known risk factors for survival or prolonged hospitalisation for single-ventricle patients are difficult to optimise prior to surgical intervention, they are still important details to consider when managing expectations for families and providers regarding healthcare burden in the first year of life.…”

Section: Discussionmentioning

confidence: 99%

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Days alive and out of hospital for children born with single-ventricle heart disease

Medina,

Prabhu,

Alderete

et al. 2024

Cardiol Young

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Background: This study describes the illness burden in the first year of life for children with single-ventricle heart disease, using the metric of days alive and out of hospital to characterize morbidity and mortality. Methods: This is a retrospective single-centre study of single-ventricle patients born between 2005 and 2021 who had their initial operation performed at our institution. Patient demographics, anatomical details, and hospitalizations were extracted from our institutional single-ventricle database. Days alive and out of hospital were calculated by subtracting the number of days hospitalized from number of days alive during the first year of life. A multivariable linear regression with stepwise variable selection was used to determine independent risk factors associated with fewer days alive and out of hospital. Results: In total, 437 patients were included. Overall median number of days alive and out of hospital in the first year of life for single-ventricle patients was 278 days (interquartile range 157–319 days). In a multivariable analysis, low birth weight (<2.5kg) (b = −37.55, p = 0.01), presence of a dominant right ventricle (b = −31.05, p = 0.01), moderate-severe dominant atrioventricular valve regurgitation at birth (b = −37.65, p < 0.05), index hybrid Norwood operation (b = −138.73, p < 0.01), or index heart transplant (b = −158.41, p < 0.01) were all independently associated with fewer days alive and out of hospital. Conclusions: Children with single-ventricle heart defects have significant illness burden in the first year of life. Identifying risk factors associated with fewer days alive and out of hospital may aid in counselling families regarding expectations and patient prognosis.

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Section: Discussionmentioning

confidence: 99%