Hospital-related morbidity in people notified with hepatitis C: A population-based record linkage study in New South Wales, Australia

Gidding, Heather F.; Amin, Janaki; Dore, Gregory J.; Ward, Kate; Law, Matthew

doi:10.1016/j.jhep.2010.01.036

Cited by 15 publications

(18 citation statements)

References 26 publications

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“…In contrast, it is estimated that over 50% of HBV cases are immigrants from HBV endemic countries in South-East and North-East Asia [23] with predominant perinatal or early childhood acquisition. A high proportion of the all cause hospitalizations amongst the HCV cohort in the less than 30 year age group has previously been reported to be lifestyle-related admissions such as drug and alcohol use [24]. Such factors may also explain the high rates of all cause hospitalization in young adults in the HIV co-infected cohorts.…”

Section: Discussionmentioning

confidence: 98%

Trends in all cause and viral liver disease-related hospitalizations in people with hepatitis B or C: a population-based linkage study

et al. 2011

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BackgroundPrevious studies have reported an excess burden of cancer and mortality in populations with chronic hepatitis B (HBV) or C (HCV), but there are limited data comparing hospitalization rates. In this study, we compared hospitalization rates for all causes and viral liver disease in people notified with HBV or HCV in New South Wales (NSW), Australia.MethodsHBV and HCV notifications were linked to their hospital (July 2000-June 2006), HIV and death records. Standardized hospitalization ratios (SHRs) were calculated using rates for the NSW population. Random effects Poisson regression was used to examine temporal trends.ResultsThe SHR for all causes and non alcoholic liver disease was two-fold higher in the HCV cohort compared with the HBV cohort (SHRs 1.4 (95%CI: 1.4-1.4) v 0.6 (95%CI: 0.6-0.6) and 14.0 (95%CI: 12.7-15.4) v 5.4 (95%CI: 4.5-6.4), respectively), whilst the opposite was seen for primary liver cancer (SHRs 16.2 (95%CI: 13.8-19.1) v 29.1 (95%CI: 24.7-34.2)). HIV co-infection doubled the SHR except for primary liver cancer in the HCV/HIV cohort. In HBV and HCV mono-infected cohorts, all cause hospitalization rates declined and primary liver cancer rates increased, whilst rates for non alcoholic liver disease increased by 9% in the HCV cohort but decreased by 14% in the HBV cohort (P < 0.001).ConclusionHospital-related morbidity overall and for non alcoholic liver disease was considerably higher for HCV than HBV. Improved treatment of advanced HBV-related liver disease may explain why HBV liver-related morbidity declined. In contrast, HCV liver-related morbidity increased and improved treatments, especially for advanced liver disease, and higher levels of treatment uptake are required to reverse this trend.

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Section: Discussionmentioning

confidence: 98%

Trends in all cause and viral liver disease-related hospitalizations in people with hepatitis B or C: a population-based linkage study

et al. 2011

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“…3, the proportion with an SVR was similar among those with (70%, 26 of 37) and without a history of injecting drug use (75%, three of four, P = 1.00). There was also no difference in the SVR between those currently (64%, nine of 14) or not currently receiving OST (74%, 20 of 27; P = 0.719). There was also no difference in the SVR between those currently (64%, nine of 14) or not currently receiving OST (74%, 20 of 27; P = 0.719).…”

Section: Hepatitis C Virus Treatment Outcomesmentioning

confidence: 89%

“…The increasing burden of HCV-related liver disease in Australia and other countries [2,7,14,15] is related to the 'ageing cohort' nature of the population with chronic HCV infection, ongoing low HCV treatment uptake and suboptimal treatment outcomes, particularly among those with more advanced liver disease. This pilot study and several other initiatives in the OST clinic, prison and community-based settings [16,17] provide a valuable foundation upon which to build an expanded infrastructure for delivery of chronic HCV treatment to address this growing public health burden.…”

Section: Discussionmentioning

confidence: 99%

Delivery of treatment for hepatitis C virus infection in the primary care setting

Baker¹,

Alavi²,

Erratt³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

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“…The high prevalence of HCV in patients undergoing dialysis is already known [17] and dialysis accounted for by far the highest number of admissions in our cohort (17 % of all admissions, rate 9 . 9/100 personyears) [4] and could therefore subsume any other associations.…”

Section: Exclusionsmentioning

confidence: 99%

“…Infection with hepatitis C virus (HCV) is known to be associated with increased morbidity compared to the general population [1][2][3][4][5][6] and certain cofactors are thought to add to this burden. There is good evidence that age at infection, duration of infection, male gender, and co-infection with either HIV or hepatitis B virus (HBV) are predictors of liver disease progression in people with chronic HCV [7,8].…”

Section: Introductionmentioning

confidence: 99%

Hospitalization rates associated with hepatitis B and HIV co-infection, age and sex in a population-based cohort of people diagnosed with hepatitis C

et al. 2010

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To determine the extent age, sex and co-infection affect morbidity in people infected with hepatitis C virus (HCV), we performed a population-based study linking HCV notifications in New South Wales, Australia with their hospital (July 2000 to June 2006), hepatitis B virus (HBV) and HIV notification, and death records. Poisson models were used to calculate hospitalization rate ratios (RRs) for all-cause, illicit drug and liver-related admissions. Co-infection RRs were used to estimate attributable risk (AR). The 86 501 people notified with HCV contributed 422 761 person-years of observation; 0·8% had HIV, 3·7% HBV, and 0·04% had both. RRs for males were equal to or lower than for females in younger ages, but higher in older ages (P for interaction ⩽0·013). HBV/HIV co-infection resulted in ARs of over 70% for liver disease and 30-60% otherwise. However, at the cohort level the impact was minimal (population ARs 1·3-8·7%). Our findings highlight the importance and success of public health measures, such as needle and syringe exchange programmes, which have helped to minimize the prevalence of co-infection in Australia. The findings also suggest that the age of study participants needs to be considered whenever the burden of HCV-related morbidity is reported by sex. The results are likely to be representative of patterns in hospital-related morbidity for the entire HCV-infected population in Australia and the ARs generalizable to other developed countries.

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Hospital-related morbidity in people notified with hepatitis C: A population-based record linkage study in New South Wales, Australia

Cited by 15 publications

References 26 publications

Trends in all cause and viral liver disease-related hospitalizations in people with hepatitis B or C: a population-based linkage study

Trends in all cause and viral liver disease-related hospitalizations in people with hepatitis B or C: a population-based linkage study

Delivery of treatment for hepatitis C virus infection in the primary care setting

Hospitalization rates associated with hepatitis B and HIV co-infection, age and sex in a population-based cohort of people diagnosed with hepatitis C

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