Hospital care for primary hyperparathyroidism in Italy: a 6-year register-based study

Cipriani, Cristiana; Carnevale, Vincenzo; Biamonte, Federica; Piemonte, Sara; Pepe, Jessica; Nieddu, Luciano; Bilezikian, John P.; Minisola, Salvatore

doi:10.1530/eje-14-0493

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…We found a mean hospitalization rate for hypoparathyroidism of 5.9/100,000 inhabitants per year in the period 2006-2013 that represents a relevant figure considering the same data in PHPT patients in the period 2006-2011 (12.9/ 100,000) [7]. Hence, hospitalization rate for Fig.…”

Section: Discussionsupporting

confidence: 60%

“…Hence, hospitalization rate for Fig. 4 Prevalence of different forms of hypoparathyroidism/ 100,000 per year in Italy (excluding repeated hospitalizations) among inpatients hypoparathyroidism in Italy is almost the half the rate for PHPT, one of the most common endocrine disorders [7,8]. Different points should be taken into account in explaining why many patients with hypoparathyroidism, a disease usually managed in the outpatient setting, need hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…Detailed description of the SDO is provided in a previously published paper from our group [7]. Among variables available in the SDO, the following were considered: regional code (region of hospitalization), sex, age, date of hospitalization, date of discharge, days of hospitalization of the patient, and patient's ID.…”

Section: Methodsmentioning

confidence: 99%

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The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study

et al. 2016

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Hypoparathyroidism is a rare endocrine disorder, but few studies have focused on the epidemiology and hospital management of the disease and none has been performed in Italy. We investigated the prevalence of different forms of hypoparathyroidism among hospitalized patients in Italy during an 8-year period. This study is designed as a retrospective register-based study. We retrieved data from the ''Record of Hospital Discharge'' (SDO) of the Italian Health Ministry, from the year 2006 to 2013 and analyzed the codes corresponding to hypoparathyroidism-related diagnoses. The inpatient prevalence of the disease was also calculated after excluding repeated hospitalizations. Overall, 27,692 hospitalization episodes for hypoparathyroidism were identified during the entire period (72.2% in women and 27.8% in men; mean age 49.5 ± 22.9 years). The mean length of stay was 7.4 ± 9.8 days (25.9% of the episodes requiring less than 3 days of stay). The mean hospitalization rate for hypoparathyroidism was 5.9/100,000 inhabitants per year and there was a significant decrease during the period of 2006-2013 (p \ 0.0001). The mean hospitalization rate for postsurgical hypoparathyroidism was 1.4/100,000 inhabitants per year and the trend showed a significant reduction during the years (p \ 0.0001). The mean prevalence of hypoparathyroidism among inpatients was 5.3/100,000 inhabitants per year, and there was a significant decrease over the years (p \ 0.0001). Hypoparathyroidism, particularly the postsurgical form of the disease, is not an uncommon condition among hospitalized patients in Italy. We observed a tendency to a decrease in the frequency of hospitalization during the period 2006-2013.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study

et al. 2016

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“…Nephrolithiasis prevalence has decreased and overt skeletal manifestations are uncommon. Normocalcemic hyperparathyroidism (NPHPT) may be identified during the evaluation of patients with low BMD [63]. …”

Section: Presentationmentioning

confidence: 99%

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

et al. 2016

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The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.

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“…They also report a concomitant increase in the age of the patients, and, most notably, a progressive increase in the frequency of parathyroidectomy among patients admitted for PHPT. 24 …”

Section: Presentation In Europementioning

confidence: 99%