Hospital-based study on emergency admission in patients with Parkinson's disease

Fujioka, Shinsuke; Fukae, Jiro; Ogura, Hiromu; Mishima, Takayasu; Yanamoto, Shozaburo; Higuchi, Masaaki; Umemoto, George; Tsuboi, Yoshio

doi:10.1016/j.parkreldis.2015.10.050

Cited by 1 publication

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“…Similar to our findings, a recent meta-analysis identified infections (urinary tract infection and pneumonia), gastrointestinal disorders, and falls/fractures as the top three causes of PD admissions (6). Previous studies on hospital admissions among patients with PD from other countries such as Ireland, India, Italy, Japan, Australia, and Singapore had similar findings, with the most common PD-related causes being infection (respiratory, urinary tract, sepsis, and aspiration pneumonia) and trauma due to falls with or without fracture (10,(19)(20)(21)(22)(23)(24). Non-PD-related causes included myocardial infarction, arrhythmia, congestive cardiac failure, stroke, seizures, and renal failure (10).…”

Section: Discussionmentioning

confidence: 81%

Causes, factors, and complications associated with hospital admissions among patients with Parkinson's disease

et al. 2023

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IntroductionPatients with Parkinson's disease (PD) are at a higher risk of hospital admissions compared to the general population. We studied the causes and factors associated with admissions among patients with PD over 6 years.MethodsWe included all PD admissions between 1 January 2016 and 31 December 2021. Other causes of parkinsonism were excluded. Causes of admissions were divided into PD-related (direct or indirect) or non-PD-related. The type of admission was categorized into emergency or elective.ResultsWe identified 605 hospital admissions (259 patients with PD); 345 (57.0%) were PD-related and 260 (43%) were non-PD-related. Emergency PD admissions contributed to 50.4% of all admissions, most commonly from respiratory infection (23%). PD admissions in comparison to non-PD admissions were associated with worse disease severity (HY ≥ 3; p < 0.001), longer disease duration [8.71 (SD 6.23) vs. 6.60 (SD 5.39) years; p < 0.001], and longer hospital stay [7.70 (SD 5.89) vs. 6.42 (SD 7.63) days; p = 0.020]. Non-PD admissions were associated with more comorbidities (97.3%; p = 0.013). There were 124 (20.5%) complications and 31 deaths (5.1%). A total of 29 deaths were due to respiratory infection and 3 deaths were due to COVID-19 pneumonia. Emergency admission (PD- and non-PD-related; p = 0.001) and respiratory-related causes (p < 0.001) were predictors of unfavorable hospital admission outcomes (death and complications).ConclusionRespiratory infection was the leading cause of hospital admission and a significant independent predictor of unfavorable hospital admission outcomes (death and complications). PD-related admissions were associated with disease severity and led to more complications and longer hospital stays. Non-PD-related admissions were associated with comorbidities.

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