Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls

Tanvir, Imrana; Riaz, Shazia; Hussain, Akmal; Mehboob, Riffat; Shams, Mahin; Khan, Haseeb A.

doi:10.1155/2014/179384

Cited by 11 publications

(11 citation statements)

References 24 publications

(34 reference statements)

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“…Ovarian cancer patients in Sudan were mostly of the age group 60–70 years with most patients reporting vague and non-specific symptoms as has been previously reported in the African region and globally [ 19 , 20 ]. Serous adenocarcinomas were seen in the majority of our patients with advanced disease in more than half, while other histological types were seen in the minority in agreement with previous reports [ 21 , 22 ]. The low diagnostic sensitivity, the high specificity and the high negative predictive value of plasma CA125 test were confirmed in this study.…”

Section: Discussionsupporting

confidence: 93%

Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis

et al. 2020

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Ovarian cancer is the second major lethal gynecologic malignancy in developing countries. This study aimed to characterize urinary micro-peptides as potential diagnostic biomarkers for ovarian cancer. In a prospective, longitudinal and case-controlled study and following informed consent, urine and plasma samples were collected from 112 women with histologically-proven ovarian cancer and 200 apparently healthy age-matched volunteers. Urinary micro-peptides were detected and sequenced using SDS-PAGE and Edman degradation technique. Serum CA125 was detected in less than a quarter (23.2%, 26/112) of patients. One or more urinary micro-peptides were detected in about two thirds of the patients (62.5%, 70/112). A total of 40 patients had three bands (57.1%, 40/70), while two bands (15 and 35 kDa) were detected in 28.6% (20/70) of the patients. Isolated 45 kDa band was seen in 14.3% (10/70). No urinary micro-peptide was detected in the volunteers. The 15 and 35 kDa bands disappeared after 6 months of regular chemotherapy, while the 45 kDa band persisted in 2.9% (2/70) of the patients after treatment. The micro-peptides were identified as: Catalase (45 kDa), α-1 Acid Glycoprotein (35 kDa) and Peroxiredoxin-2 (15 kDa). Urinary catalase, α-1 Acid Glycoprotein and Peroxiredoxin-2 can be useful biomarkers for early detection and treatment response of ovarian cancer.

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Section: Discussionsupporting

confidence: 93%

Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis

et al. 2020

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“…11 Adenoma malignum pattern of myoinvasion merits awareness from a diagnostic standpoint because it may be difficult to distinguish may lead to more accurate staging, but perhaps more importantly, some patterns may be associated from non-invasive cancer in the setting of an undulating endomyometrial junction, to distinguish from involvement of stroma-poor adenomyosis or to measure true depth of invasion. 12,13 In our study, the most common pattern was of infiltrative irregular glands pattern of myoinvasion i.e. 43.75%.…”

Section: Discussionmentioning

confidence: 52%

Patterns of Myoinvasion in Endometrioid Adenocarcinoma of Endometrium

Shakeel

Mushtaq

Akhtar

et al. 2022

PAFMJ

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Objective: To assess the patterns of myoinvasion of endometrial endometrioid adenocarcinoma, their frequencies in our hospital and to correlate these patterns with survival. Study Design: Retrospective observational study. Place and Duration of Study: Department of Pathology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, from Aug 2019 to Apr 2020. Methodology: All cases of endometrial endometrioid adenocarcinoma between 2015 and 2017 were retrieved from the archives, independently reviewed by two researchers, all key reporting parameters recorded in addition to the pattern of myoinvasion as per their operational definitions described by Cole and Quick. The follow-up of 3-5 years was obtained from archives and through telephonic contact for outside hospital patients. Disease free survival and relapse-associated mortality were represented through Kaplan-Meier curves. Results: Eighty cases of myoinvasive endometrial endometrioid adenocarcinoma were reviewed. We found that infiltrating irregular gland pattern was the most frequent in all the age groups. Thirty-five (43.75%) cases showed this type of invasion, followed by broad front pattern 23 (28.75%), Microcystic Elongated and Fragmented (MELF) pattern 15 (18.75%) and adenomyotic pattern 6 (7.5%). One case showed a combination of the last two patterns, whereas adenoma malignum pattern was not seen. Follow-up of these patients showed 8 (10%) patients with relapse related mortality including 5 (62.5%) infiltrating irregular glands, 2 (25%) adenomyosis-like and 1 (12.5%) broad front pattern of myoinvasion. Seventy-two (90%) patients had recurrence free survival. Conclusion: Frequency of infiltrating irregular pattern of myoinvasion in endometrial endometrioid adenocarcinoma is high and associated with recurrence related mortality. Recognition....................

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“…This is similar to results of the study by P S Rathod, where 66% (81/123 cases) belonged to Grade 1 and grade 2. Tumors other than endometrioid and mucinous carcinomas in which FIGO grading is not applicable were regarded as high grade [8].…”

Section: Resultsmentioning

confidence: 99%

A Clinicopathological Study of Malignant Tumors of the Uterine Corpus in a Tertiary Care Center

Binu

Diwagar

Sekhar

2021

JPRI

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Aim: To study the clinicopathological spectrum of malignant tumors of the uterine corpus in a tertiary care center and classify it according to the latest WHO classification. Methods: A 2 year study was conducted on 22 diagnosed cases of malignant tumors of uterine corpus. Retrospectively clinical and histopathological details were collected and analyzed. Results: In our study majority (40.90%, 9 of 22) cases belong to the age group of 51-60 years. Abnormal uterine bleeding was the most common clinical presentation. A large share (81.81%) of the tumours was of epithelial origin, followed by mixed and mesenchymal tumors. Nearly 94% of the epithelial tumours were Endometrioid Adenocarcinomas. Majority of the cases were at pT1a stage (42.1%) at the time of diagnosis, followed by pT1b stage (31.57%). Very few cases (21%) presented with nodal metastasis. All the cases with nodal metastasis showed Lymphovascular invasion in the tumor proper and were usually high grade tumors. Conclusion: The prognosis of the patients with malignant tumors of uterine corpus depends on stage, grade, myometrial invasion, tumor size, lymphovascular invasion etc. Clinical findings in these tumors are not specific, so Histopathological examination plays a vital role in diagnosing and assessing the prognosis of these tumors. Classifying these tumors according to the recently proposed molecular classification will aid in patient specific targeted therapy.

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Hospital-Based Study of Epithelial Malignancies of Endometrial Cancer Frequency in Lahore, Pakistan, and Common Diagnostic Pitfalls

Cited by 11 publications

References 24 publications

Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis

Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis

Patterns of Myoinvasion in Endometrioid Adenocarcinoma of Endometrium

A Clinicopathological Study of Malignant Tumors of the Uterine Corpus in a Tertiary Care Center

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