Hospital Based Quality of Life in Oral Cancer Surgery

Goetz, Carolin; Raschka, Julius; Wolff, Klaus‐Dietrich; Kolk, Andreas; Bissinger, Oliver

doi:10.3390/cancers12082152

Cited by 11 publications

(5 citation statements)

References 31 publications

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“… 15 – 17 Traditionally, invasion and metastasis are late events in the progression of oral cancer. 17 – 19 At present, it is believed that during the early stage of oral cancer, tumor cells have begun to infiltrate, 20 , 21 but the regulatory mechanism unclear.…”

Section: Discussionmentioning

confidence: 99%

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

Chen

Zhang

et al. 2021

J Int Med Res

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Objective To study the relationship between the circular RNA vesicle-associated membrane protein-associated protein A (circVAPA) and the pathogenesis of oral squamous cell carcinoma. Methods The expression of circVAPA was detected by RT-qPCR. In vitro loss-of-function experiments were performed in Cal-27 cells. The malignant phenotype of cells was evaluated by cell counting kit-8, clone formation and transwell assays. Luciferase reporter assays were used to assess the circVAPA/miR-132/homeobox A (HOXA) regulatory axis. Results circVAPA expression was significantly increased in oral cancer tissues and cells. The overall survival and progression-free survival of patients with oral cancer who exhibited high circVAPA expression were significantly shorter compared with those with low expression. circVAPA expression was closely related to tumor size, TNM stage and distant metastasis. circVAPA knockdown reduced the proliferation, invasion and migration of Cal-27 cells. MiR-132 was identified as a target of circVAPA in Cal-27 cells. Cotransfection with si-circVAPA and miR-132 inhibitor reversed the inhibitory effect of circVAPA knockdown on cell malignant phenotypes. HOXA7 was further identified as a downstream target of miR-132. Conclusion circVAPA is highly expressed in oral cancer, and its abnormal expression might affect the proliferation, invasion and migration of oral cancer cells by modulating the miR-132/HOXA7 signaling axis.

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Section: Discussionmentioning

confidence: 99%

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

Chen

Zhang

et al. 2021

J Int Med Res

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“…Self-reported quality of life using EORTC QOL C30 and BDI-S will enable us to gain concrete information about the effect of deterioration of motor function on the patient's quality of life and their emotional health. These questionnaires have been validated in numerous papers addressing quality of life in cancer patients [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial

et al. 2021

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Background: Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. Methods: This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. Discussion: The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other.

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“…In the current global context, the most sought-after treatment modality is the one that stresses patient autonomy [1]. Even in the treatment of patients with oral cancer, there is a tendency toward individualized management that includes numerous outcomes beyond just survival and response rate.…”

Section: Background and Introductionmentioning

confidence: 99%

Light gradient boosting-based prediction of quality of life among oral cancer-treated patients

Ramalingam,

Yadalam,

Ramani

et al. 2024

BMC Oral Health

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Background and introduction Statisticians rank oral and lip cancer sixth in global mortality at 10.2%. Mouth opening and swallowing are challenging. Hence, most oral cancer patients only report later stages. They worry about surviving cancer and receiving therapy. Oral cancer severely affects QOL. QOL is affected by risk factors, disease site, and treatment. Using oral cancer patient questionnaires, we use light gradient Boost Tree classifiers to predict life quality. Methods DIAS records were used for 111 oral cancer patients. The European Organisation for Research and Treatment of Cancer’s QLQ-C30 and QLQ-HN43 were used to document the findings. Anyone could enroll, regardless of gender or age. The IHEC/SDC/PhD/OPATH-1954/19/TH-001 Institutional Ethical Clearance Committee approved this work. After informed consent, patients received the EORTC QLQ-C30 and QLQ-HN43 questionnaires. Surveys were in Tamil and English. Overall, QOL ratings covered several domains. We obtained patient demographics, case history, and therapy information from our DIAS (Dental Information Archival Software). Enrolled patients were monitored for at least a year. After one year, the EORTC questionnaire was retaken, and scores were recorded. This prospective analytical exploratory study at Saveetha Dental College, Chennai, India, examined QOL at diagnosis and at least 12 months after primary therapy in patients with histopathologically diagnosed oral malignancies. We measured oral cancer patients’ quality of life using data preprocessing, feature selection, and model construction. A confusion matrix was created using light gradient boosting to measure accuracy. Results Light gradient boosting predicted cancer patients’ quality of life with 96% accuracy and 0.20 log loss. Conclusion Oral surgeons and oncologists can improve planning and therapy with this prediction model.

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Hospital Based Quality of Life in Oral Cancer Surgery

Cited by 11 publications

References 31 publications

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

Transcranial versus Direct Cortical Stimulation for Motor-Evoked Potentials during Resection of Supratentorial Tumors under General Anesthesia (The TRANSEKT-Trial): Study Protocol for a Randomized Controlled Trial

Light gradient boosting-based prediction of quality of life among oral cancer-treated patients

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