Hospital admissions of adults with community-acquired pneumonia in Portugal between 2000 and 2009

Froes, Filipe; Diniz, António; Mesquita, Margarida; Serrado, Margarida; Nunes, Baltazar

doi:10.1183/09031936.00216711

Cited by 38 publications

(38 citation statements)

References 15 publications

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“…Furthermore the incidence of Community-acquired Pneumonia (CAP) hospital admissions has also been reported to have increased 28.2 % between the first and the second half of the past decade [4]. Therefore, the number of nursing home residents and the frequency of NHAP should also be expected to increase, although current data on its incidence are scarce.…”

Section: Introductionmentioning

confidence: 99%

Nursing home-acquired pneumonia presenting at the emergency department

2016

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Nursing home-acquired pneumonia (NHAP) is one of the most common infections arising amongst nursing home residents, and its incidence is expected to increase as population ages. The NHAP recommendation for empiric broad-spectrum antibiotic therapy, arising from the concept of healthcare-associated pneumonia, has been challenged by recent studies reporting low rates of multidrug-resistant (MDR) bacteria. This single center study analyzes the results of NHAP patients admitted through the Emergency Department (ED) at a tertiary center during the year 2010. There were 116 cases, male gender corresponded to 34.5 % of patients and median age was 84 years old . Comorbidities were present in 69.8 % of cases and 48.3 % of patients had used healthcare services during the previous 90 days. In-hospital mortality rate was 46.6 % and median length-of-stay was 9 days. Severity assessment at the Emergency Department provided CURB65 index score and respective mortality (%) results: zero: n = 0; one: n = 7 (0 %); two: n = 18 (38.9 %); three: n = 26 (38.5 %); four: n = 30 (53.3 %); and five; n = 22 (68.2 %); and sepsis n = 50 (34.0 %), severe sepsis n = 43 (48.8 %) and septic shock n = 22 (72.7 %). Significant risk factors for in-hospital mortality in multivariate analysis were polypnea (p = 0.001), age C 75 years (p = 0.02), and severe sepsis or shock (p = 0.03) at the ED. Microbiological testing in 78.4 % of cases was positive in 15.4 % (n = 15): methicillinresistant Staphylococcus aureus (26.7 %), Pseudomonas aeruginosa (20.0 %), S. pneumoniae (13.3 %), Escherichia coli (13.3 %), others (26.7 %); the rate of MDR bacteria was 53.3 %. This study reveals high rates of mortality and MDR bacteria among NHAP hospital admissions supporting the use of empirical broad-spectrum antibiotic therapy in these patients.

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Section: Introductionmentioning

confidence: 99%

Nursing home-acquired pneumonia presenting at the emergency department

2016

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“…The incidence was estimated higher in a recent Portuguese study for the same age group, with 361 per 100,000 population [6]. Other recent studies found annual incidences of hospitalized CAPs of 366, 472, 518, 627 and 832 per 100,000 inhabitants for those aged ≥50 years in Czech republic, Slovakia, Poland, Spain and Hungary, respectively [5,8].…”

Section: Comparisons To Other Database Studiesmentioning

confidence: 96%

Incidence, direct costs and duration of hospitalization of patients hospitalized with community acquired pneumonia: A nationwide retrospective claims database analysis

Rozenbaum

Mangen

Huijts

et al. 2015

Vaccine

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“…Some recently published studies report an increase of hospital admissions due to CAP of about 30% in the last decade, suggesting that the annual incidence rates might have increased [12,16]. On the other hand, a study from the USA presented opposing findings, with the number of CAP hospitalizations declining by 54.8 per 100 000 annually after the initiation of PCV7 vaccination, leading to 168 000 fewer hospitalizations per year [17].…”

Section: Incidence Of Capmentioning

confidence: 99%

Pneumococcal infection in adults: burden of disease

Drijkoningen

Rohde

2014

Clinical Microbiology and Infection

295

213

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To overview the present global burden of pneumococcal disease is important because new preventive measures such as the pneumococcal conjugate vaccine 13 are currently being evaluated. Pneumococcal disease is roughly divided into non-invasive and invasive disease. The burden of non-invasive pneumococcal disease in adults is mainly determined by community-acquired pneumonia. Pneumococcal pneumonia has high incidence rates and carries a high mortality risk, especially in the elderly. Within the cluster of invasive pneumococcal diseases, pneumonia also represents the most common infectious source. Incidence and mortality rates of both non-invasive and invasive disease have changed as a result of pneumococcal vaccination in children. However, especially elderly patients with comorbidities remain vulnerable to morbidity and mortality caused by pneumococcal disease. The current review summarizes the current knowledge on the epidemiology including outcome of the main clinical forms of pneumococcal disease, with a special focus on elderly patients. Furthermore, the economic burden and future vaccine strategies are briefly discussed.

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Hospital admissions of adults with community-acquired pneumonia in Portugal between 2000 and 2009

Cited by 38 publications

References 15 publications

Nursing home-acquired pneumonia presenting at the emergency department

Nursing home-acquired pneumonia presenting at the emergency department

Incidence, direct costs and duration of hospitalization of patients hospitalized with community acquired pneumonia: A nationwide retrospective claims database analysis

Pneumococcal infection in adults: burden of disease

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