Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study

Abstract

None.

30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study

“…Routine use of the MMR vaccine has resulted in reduction in disease burden from measles, mumps and rubella. 7,10 While its specific effect on the incidence of measles and mumps encephalitis has been demonstrated in some countries, 11,12 data for England are lacking. In this study, admissions for measles encephalitis were high prior to the mid 1980's, when the single measles vaccine was being used and when coverage was low (<60%) and insufficient to fully interrupt transmission.…”

“…Details of these national sources are described elsewhere. 7 Briefly, HIPE contained a random 10% sample of every National Health Service (NHS) hospital admission in England, whereas HES was a complete dataset (100%). For this paper, HIPE numbers are unscaled but the associated rates are scaled to the equivalent of 100%.…”

Enteroviral and Herpes Simplex Virus Central Nervous System Infections in Infants &lt;90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

“…Trends in Canada are not clear but in a populationbased United Kingdom (UK) study, the authors document a dramatic rise in admissions for viral meningitis in infants between 2005 and 2011. 7 They show a major increase in the proportion of cases of viral meningitis recognized to be due to EV over time, from 90 (3%) of 2770 admissions for viral meningitis in 1968-1985 to 811 (47%) of 1716 viral meningitis admissions in 2007-2011. 7 These changing trends probably reflect the UK adoption of molecular diagnostic screening for viral meningitis resulting in increased detection over conventional viral culture methods which were not consistently applied in earlier years.…”

“…7 They show a major increase in the proportion of cases of viral meningitis recognized to be due to EV over time, from 90 (3%) of 2770 admissions for viral meningitis in 1968-1985 to 811 (47%) of 1716 viral meningitis admissions in 2007-2011. 7 These changing trends probably reflect the UK adoption of molecular diagnostic screening for viral meningitis resulting in increased detection over conventional viral culture methods which were not consistently applied in earlier years. 8 Further, molecular testing has facilitated the detection of viruses like HPeV that are missed by viral isolation techniques.…”

Clinical Characteristics and Epidemiology of Enteroviral Meningitis Compared to Non-Enteroviral Meningitis in Infants under 3 Months of Age

“…Early laboratory confirmation of enteroviral infection could change management, reducing the period of unnecessary exposure to empirical antimicrobials uses, and permitting earlier discharge [14]. Positive result from enteroviral RT-PCR test allows to discontinue the antibiotics and shortens the length of hospital admission [4]. Above all, early recognition reduce mortality rates [5].…”