Hospital admissions due to drug reactions

Larmour, Ian; McGrath, Barry P

doi:10.5694/j.1326-5377.1991.tb142200.x

Cited by 21 publications

(27 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar methods have been used successfully in at least five previous studies. [6][7][8][9][10] The principal investigator assessed possible cases using a combination of: • medical note review (throughout the admission and on discharge); • contact with general practitioners, where necessary, to obtain medication histories, test results, and information regarding the management of patients in primary care; • interviewing patients, where possible, about the type and duration of symptoms and medication use, using an interview schedule. Those not interviewed included patients discharged home before being seen by the principal investigator, patients too unwell to be interviewed, and patients unable to speak English.…”

Section: Selection Of Participantsmentioning

confidence: 99%

Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study

Howard

Avery²,

Howard³

et al. 2003

Quality and Safety in Health Care

199

146

View full text Add to dashboard Cite

Objective: To describe the drugs and types of medicine management problems most frequently associated with preventable drug related admissions to an acute medical admissions unit. Design: Observation study. Setting: Medical admissions unit in a teaching hospital in Nottingham, UK. Participants: 4093 patients seen by pharmacists on the medical admissions unit between 1 January and 30 June 2001. Main outcome measures: Proportion of admissions that were drug related and preventable, classification of the underlying causes of preventable drug related admissions, and identification of drugs most commonly associated with preventable drug related admissions. Results: Of the admissions seen by pharmacists, 265 (6.5%) were judged to be drug related and 178 (67%) of these were judged to be preventable. Preventable admissions were mainly due to problems with prescribing (63 cases (35%)), monitoring (46 cases (26%)), and adherence to medication (53 cases (30%)). The drugs most commonly implicated were NSAIDs, antiplatelets, antiepileptics, hypoglycaemics, diuretics, inhaled corticosteroids, cardiac glycosides, and beta-blockers. Conclusions: Potentially preventable drug related morbidity was associated with 4.3% of admissions to a medical admissions unit. In 91% of cases these admissions were related to problems with either prescribing, monitoring, or adherence. R ecent reports in the USA 1 and the UK 2 highlight the problem of drug related morbidity and the need to find ways to prevent medical errors. These reports suggest that preventable drug related admissions require particular attention and, in 2002, two systematic reviews were published on this topic.3 4 Winterstein et al 3 identified 15 studies of preventable drug related hospital admissions and found a median of 7.1% of admissions to be drug related, and 59% of these to be preventable. Beijer et al 4 reviewed 68 studies, 12 of which looked at preventable admissions. This review highlighted some of the limitations of previous research and emphasised the need for further studies looking at the preventability of drug related admissions and documentation of the drugs responsible for these admissions. This sort of information is needed if we are to develop effective strategies to prevent drug related admissions. In addition, it is important to identify some of the underlying causes of preventable admissions.We have addressed some of these issues by conducting a large study of drug related morbidity detected by pharmacists on a medical admissions unit in the UK. We have defined drug related morbidity as adverse drug reactions, 5 failure to optimise treatment, unintentional overdose, and adherence problems. Admissions associated with intentional overdoses and drugs of abuse were excluded.The objectives of our study were to: • estimate the proportion of admissions to an acute medical admissions unit that were associated with drug related morbidity and the proportion of these admissions that were potentially preventable; • identify the drugs associated with the preventable ...

show abstract

Section: Selection Of Participantsmentioning

confidence: 99%

Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study

Howard

Avery²,

Howard³

et al. 2003

Quality and Safety in Health Care

199

146

View full text Add to dashboard Cite

show abstract

“…[9][10][11] As with any study, a marked nonresponse rate could be suspected to convey a sample distortion bias, for example, overrepresentation of general practitioners who observed a lower or higher rate of adverse drug reactions. Moride et al 7 conducted a study in a similar population to estimate the underreporting of adverse drug reactions and found an average of 2 adverse drug reactions per general practitioner per day, 0.1 of which was serious.…”

Section: Discussionmentioning

confidence: 99%

Incidence of serious adverse drug reactions in general practice: A prospective study

Lacoste-Roussillon¹

2001

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

show abstract

“…Costing was undertaken using two methods including a clinical model and the more rudimentary average bed day cost mode 1–4 . Cost apportionment by the clinical model isolates a series of average costs for individual natural units of service such as a day in intensive care or general ward, or an operation, and aggregates these costs for a particular patient.…”

Section: Methodsmentioning

confidence: 99%

“…Medications are not without their hazards and even when taken as prescribed, toxic effects may occur. Adverse reactions to medications have been estimated to cause between 2.4% and 8% of hospital admissions 1,2 . However, many adverse drug reactions causing hospital attendance do not necessarily result in admission.…”

Section: Introductionmentioning

confidence: 99%

Patients with adverse drug reactions attending an emergency department

Collits

Kennedy

et al. 1996

Emergency Medicine

View full text Add to dashboard Cite

Aim To study the incidence and identify the economic impact of patients with adverse drug reactions attending the emergency department. Setting A metropolitan district hospital. Methods Over a one year period, all attendances were screened for adverse reactions in accordance with specific criteria. An economic assessment was conducted to ascertain the direct cost to the health care system of identified patient presentations. Results One hundred and one attendances (0.59%) were due to adverse drug reactions and adverse reactions accounted for 44 hospital admissions via the emergency department (0.88%). Using a clinical costing model, adverse drug reactions cost $162,000 per annum. Conclusion Patients with adverse drug reactions form a small percentage of attendances but are a significant cost to manage.

show abstract

Hospital admissions due to drug reactions

Cited by 21 publications

References 2 publications

Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study

Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study

Incidence of serious adverse drug reactions in general practice: A prospective study

Patients with adverse drug reactions attending an emergency department

Contact Info

Product

Resources

About