Hospital Acquired Infections Among Patients Admitted in the Medical and Surgical Wards of a Non-Teaching Secondary Care Hospital in Northern India

Ginawi, Ibrahim Abdelmageem Mohamed; Saleem, Mohd; Sigh, Mastan; Vaish, Arvind Kumar; Ahmad, Irfan; Vk, Srivastava; Abdullah, Amid

doi:10.7860/jcdr/2014/6673.4014

Cited by 14 publications

(13 citation statements)

References 13 publications

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“… 4 , 5 In addition to pneumonia, K. pneumoniae can also cause infections in the urinary tract, lower biliary tract and surgical wound sites. 6 , 7 , 8 In recent years, K. pneumoniae has become an important pathogen in nosocomial infections. Intense antibiotic use is a factor that increases the risk of nosocomial infection with Klebsiella bacteria, which are often resistant to multiple antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

et al. 2015

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The emergence of multidrug-resistant Klebsiella pneumoniae highlights the need to develop preventive measures to ameliorate Klebsiella infections. Bacteria-derived extracellular vesicles (EVs) are spherical nanometer-sized proteolipids enriched with outer membrane proteins. Gram-negative bacteria-derived EVs have gained interest for use as nonliving complex vaccines. In the present study, we evaluated whether K. pneumoniae-derived EVs confer protection against bacteria-induced lethality. K. pneumoniae-derived EVs isolated from in vitro bacterial culture supernatants induced innate immunity, including the upregulation of co-stimulatory molecule expression and proinflammatory mediator production. EV vaccination via the intraperitoneal route elicited EV-reactive antibodies and interferon-gamma-producing T-cell responses. Three vaccinations with the EVs prevented bacteria-induced lethality. As verified by sera and splenocytes adoptive transfer, the protective effect of EV vaccination was dependent on both humoral and cellular immunity. Taken together, these findings suggest that K. pneumoniae-derived EVs are a novel vaccine candidate against K. pneumoniae infections.

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Section: Introductionmentioning

confidence: 99%

Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

et al. 2015

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“…They estimated that of all the hospital acquired infections, 30% of the infections were caused by Gram negative bacteria which are responsible for causing 70% of infection in hospital with Intensive care unit. 9 Similar type of study was conducted by Ginawi et al, 10 study shows among those patients who developed Nosocomial infections where 72.8% patients isolated pathogen were Gram negative bacilli. In our study out of 1266 gram negative isolates, 1055 bacilli belongs from the family Enterobacteriaceae.…”

Section: Discussionmentioning

confidence: 58%

Resistance Pattern of Carbapenem on Enterobacteriaceae

et al. 2018

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Introduction: Gram negative bacilli are the important causes of common clinical infections. Carbapenem resistant Enterobacteriaceae are considered as important public health threat and is classified as urgent by the Centers of Disease Control and Prevention because of their progressive geographic dissemination and limited therapeutic alternatives. This study was done to find out the resistance pattern of Carbapenem among Enterobacteriaceae.Methods: The descriptive cross-sectional study was carried out in Clinical Microbiology laboratory from February 2018 to May 2018 after ethical approval. Organism was identified on the basis of its microscopic observation by performing Gram’s stain and by identification of morphology after its growth in culture media followed by its biochemical reactions. Antibiotic sensitivity test of isolated pathogens was done using Muller Hinton Agar by the standard disk diffusion technique of Kirby-Bauer method.Results: In our study, total 1055 sample belongs to the family Enterobacteriaceae. From the family Enterobactericeae, 348 (27%) of the bacilli were found to be Carbapenem resistant. Among which most common bacteria was Klebsiella pneumoniae followed by Escherichia coli. All strains of Carbapenem resistant Enterobacteriaceae were sensitive to Colistin, Polymyxin B and Tigecycline. Conclusions: Among Enterobacteriaceae, around one-third of the bacterial isolates were Carbapenem resistant. However, to reduce drug resistance antimicrobial stewardship programme and proper infection control measures is required.

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“…[20] Raheja et al [21] had reported 8% of nosocomial bloodstream infection at PGIMS Rohtak. Similarly, Pratham et al [22] reported 10.93% of incidence, and higher incidence of 28% was quoted in a study by Ginawi et al [23] Garg et al [24] reported 20% of urinary tract infection among patient admitted in ICU. In similar such study by Al-Jebouri [25] quoted 28.1% and Patel and Garala [26] quoted 34.14% of nosocomial UTI.…”

Section: Discussionmentioning

confidence: 93%

Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo beta-lactamases and AmpC

Jain¹,

Jain²,

Ranjan³

et al. 2018

Int J Med Sci Public Health

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Hospital Acquired Infections Among Patients Admitted in the Medical and Surgical Wards of a Non-Teaching Secondary Care Hospital in Northern India

Cited by 14 publications

References 13 publications

Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

Resistance Pattern of Carbapenem on Enterobacteriaceae

Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo beta-lactamases and AmpC

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