The modelling results from numerical simulations of the Early Cretaceous, Mannville coal measures with anisotropic permeability provide insights into development strategies not readily visualized or otherwise intuitive. The complex relationships between water and gas production, the contribution from multiple coal seams as well as from organic rich shales, and the impact of well interference combined with anisotropic fracture permeability are investigated through a series of numerical simulations of four well-pads (on the corners of a square mile of land with decreasing well spacing from 1, 3, to 4 laterals per pad). After 25 years of production, the two pads with optimally-oriented laterals with respect to the fracture permeability anisotropy produce 61% of the recovered gas for the 1 lateral/pad model, 52% for the 3 laterals/pad model, and 50% for the 4 laterals/pad model. Downspacing has a greater impact on increasing the gas production from pads with the poorly-oriented main laterals than from the pads with the optimally-oriented main laterals. The cumulative gas production at the end of the 25 year history is 4.2% higher for an optimally-oriented pad (pad1) and 1.1× higher for a poorly-oriented pad (pad3) for a model with 4 laterals/pad than 3 laterals/pad and an optimally-oriented pad is 1.1% higher for an optimally-oriented pad and 1.5× higher for a poorly-oriented pad for a model with 3 laterals/pad than 1 lateral/pad. Although downspacing from 3 to 4 laterals/pad has a greater impact on increasing the cumulative gas production from optimally-oriented pads than downspacing from 1 to 3 laterals/pad, the lower impact on poorly-oriented pads results in a lower total increase the cumulative gas production from the four pads.