Horner and the Syndrome of Paralysis of the Cervical Sympathetic

Fulton, John F.

doi:10.1001/archsurg.1929.01140131129078

Cited by 29 publications

(7 citation statements)

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“…Det virket som om høyre øye var litt innsunket og i tillegg hadde hun lett hengende øyelokk og anisokori med minst pupill på denne siden. Horner konkluderte med at symptomkomplekset måtte skyldes en lammelse i den sympatiske grensestrengen på halsen (3,4). Dette udødeliggjorde hans navn, men det bør nevnes at den franske fysiologen Claude Bernard (1813-1878) allerede i 1852 hadde beskrevet et tilsvarende syndrom hos forsøkskaniner som fikk skåret over sympatiske fibre på halsen, og at Silas Weir Mitchell (1829-1914) i 1864 beskrev en isolert Horner-triade hos en 24 år gammel soldat med skuddskade i halsen (5).…”

Section: Historikkunclassified

Ervervet Horners syndrom

Alstadhaug¹

2011

Tidsskriftet

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Section: Historikkunclassified

Ervervet Horners syndrom

Alstadhaug¹

2011

Tidsskriftet

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“…The article, entitled ''Ü ber eine Form von Ptosis'' (On a Form of Ptosis), gave a detailed description of what is now known as Horner's syndrome. The translation, first published by Fulton (1929a), follows in its entirety.…”

Section: The Syndrome: Horner's Original Accountmentioning

confidence: 99%

“…There appears to be considerable support for the view that it should have been named for Claude Bernard (Bonnet, 1957;Geeraets,1976). Other published accounts of the syndrome (Fulton, 1929a;Lebensohn, 1969;Talbott, 1970;Pearce, 1995) have drawn attention to the contributions of Pourfour du Petit (1727), Hare (1838); Claude Bernard (1852), and Mitchell et al (1863). In the French medical literature, the syndrome is commonly referred to as Claude Bernard-Horner syndrome (Bonnet ,1957;Lebensohn, 1969).…”

Section: Whose Syndrome Is It?mentioning

confidence: 99%

“…He clarified that the ''intercostal nerve'' originated from the spinal cord and that it was not a cranial nerve as had been suggested by earlier workers. In 1727, Pourfour du Petit published, in the Histoire de l'Academie Royale des Sciences'' of Paris, the findings of experiments on dogs showing that section of the vagosympathetic nerve resulted in ''depression of the globe, diminished convexity of the cornea, narrowing of the palpebral fissure, injection of the conjunctiva and relaxation of the nictitating membrane'' (cited by Fulton, 1929a). In 1938, Robert Remak (1815-1865 gave a detailed description of the topography of the autonomic system in his doctoral thesis, ''Observationes Anatomicae et Microscopicae de Systematis Nervosi Structura,'' published in Berlin (cited by Talbott, 1970).…”

Section: Whose Syndrome Is It?mentioning

confidence: 99%

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Horner's syndrome revisited: With an update of the central pathway

Amonoo-Kuofi

1999

Clin. Anat.

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A brief summary is presented of the life of Johann Friedrich Horner, the eminent Swiss ophthalmologist, renowned for describing the effects of paralysis of the human cervical sympathetic nerves. His early education, the quality of his professional training, and the influence of his mentors, notably Carl Ludwig and Albrecht von Graefe, contributed to his discovery of the syndrome. The full text of Horner's original work (translated by J. F. Fulton, 1929a, Arch. Surg. 18:2025–2039) is cited. The history of clinical and experimental work carried out on the autonomic nervous system prior to Horner's discovery is reviewed, including the studies of Pourfour du Petit (cited in Fulton, 1929a and Singer and Underwood, 1962, Clarendon); Hare, 1838, Lond. Med. Gaz. 23:16–18; Bernard (cited by Singer and Underwood); Budge (1853, Acad. de Sci., p.377–378); Mitchell et al. (1864, Lippincott). Hare and Mitchell et al. came close to making the discovery but were apparently hindered by their inability to interpret the signs they elicited in their patients. The experiments of Claude Bernard gave succinct accounts of the effects of damage to the cervical sympathetic nerves in animals, although there appears to be no evidence that he made similar observations in humans. Horner was the first to give a detailed, scientifically supported account and accurately interpret the signs of cervical sympathetic nerve damage in a human subject. The anatomy of the pathway is reviewed and the detailed structure of its central part updated. Evidence from computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and single‐photon‐emission computerized tomography (SPECT) studies have confirmed that reciprocally connected centers in the insular cortex, central nucleus of amygdala, hypothalamus, mesencephalic and pontine tegmentum, nucleus of tractus solitarius, and the ventrolateral medulla form the central pathway. The nucleus of tractus solitarius is probably the main reflex center for the sympathetic system, whereas the ventrolateral medulla serves as the pathway through which the central neurons influence the preganglionic neurons of the thoracolumbar outflow. Emotional and sensory inputs from the frontal and somatosensory cortices provide the inputs needed by the insula to drive the sympathetic nervous system to produce appropriate responses. Clin. Anat. 12:345‐361, 1999. © 1999 Wiley‐Liss, Inc.

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“…It is characterized by a classic constellation of signs comprising ipsilateral blepharoptosis, pupillary miosis, and facial anhidrosis. 1 The syndrome can result from any disruption of the sympathetic innervation to the eye and ocular adnexa. Differential diagnoses for the pathology responsible for the sympathetic disruption range from benign to life-threatening conditions such as carotid artery dissection and malignancies.…”

Section: Introductionmentioning

confidence: 99%

Isolated Horner syndrome as a rare initial presentation of nasopharyngeal carcinoma: a case report

Padungkiatsagul¹,

Poonyathalang²,

Jindahra³

et al. 2018

IMCRJ

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BackgroundHorner syndrome refers to a set of clinical presentations resulting from disruption of sympathetic innervation to the eye and adnexa. Classically, the clinical triad consists of ipsilateral blepharoptosis, pupillary miosis, and facial anhidrosis. Ocular sympathetic denervation may signify life-threatening causes. Timely investigation and accurate diagnosis are essential in patients with oculosympathetic denervation.Case presentationA 33-year-old Asian man with a heavy smoking habit presented with a 3-week history of left ptosis and no other complaints. His visual acuity was 20/20 bilaterally. An ophthalmic examination was significant for mild ptosis of his left eyelid and anisocoria (smaller left pupil), which was greater in the dark. Both pupils reacted to light briskly without an afferent pupillary defect. Anhidrosis was found on the medial side of the left forehead. A 10% cocaine test was positive. At his first visit, neurologic examination was unremarkable. Comprehensive radiological investigations were scheduled for a left-sided isolated Horner syndrome. Two weeks after his first visit, he experienced a left-sided headache along with ipsilateral Horner syndrome. Neurologic examination revealed hypoesthesia in the left cranial nerve V1–3 territories. Emergent computed tomography angiography was suspected for petrous part of the left internal carotid artery (ICA) dissection. Magnetic resonance imaging demonstrated an enhancing infiltrative lesion with its epicenter at the left sphenoid bone. The lesion encased the left ICA and invaded the left Meckel cave. Rhinoscopy with incisional biopsy revealed squamous cell nasopharyngeal carcinoma.ConclusionThis case involved an unusual initial presentation of nasopharyngeal carcinoma: isolated Horner syndrome with clinical progression to adjacent structures. Infiltration involving the Meckel cave and ICA at the foramen lacerum can present as postganglionic Horner syndrome associated with trigeminal pain and hypoesthesia. These clinical findings may mimic carotid artery dissection on computed tomography angiography. Detailed magnetic resonance imaging with careful attention to the skull base should be performed.

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Horner and the Syndrome of Paralysis of the Cervical Sympathetic

Cited by 29 publications

References 3 publications

Ervervet Horners syndrom

Ervervet Horners syndrom

Horner's syndrome revisited: With an update of the central pathway

Isolated Horner syndrome as a rare initial presentation of nasopharyngeal carcinoma: a case report

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