Hormones and the regulation of adult neurogenesis in the hippocampus and beyond: Where are we now? Introduction to the special issue on hormonal regulation of adult neurogenesis: Implications for disease

Galea, Liisa A.M.; Duarte‐Guterman, Paula

doi:10.1016/j.yfrne.2016.06.001

Cited by 4 publications

(1 citation statement)

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“…Despite a huge interest on the endogenous and exogenous factors affecting adult neurogenesis in V-SVZ-OB system ( 19 ), few studies have focused on the role of gonadal hormones. This flaw is surprising since steroids have a key role in hippocampal neurogenesis both during development and in adulthood ( 20 – 22 ). Furthermore, V-SVZ-OB system is involved in social and reproductive behaviors, which are strongly regulated by sexual steroids ( 23 , 24 ) and are targets for xenoestrogens ( 25 – 27 ).Moreover, estrogen receptors (ERs) and enzymes involved in the biosynthesis of steroids such as aromatase, the enzyme converting testosterone (T) into estradiol, are expressed in the V-SVZ ( 28 ) and in the OB of adult ( 29 , 30 ) and developing ( 31 ) rats and mice ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

Sex Steroids and Adult Neurogenesis in the Ventricular-Subventricular Zone

2018

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The forebrain ventricular-subventricular zone (V-SVZ) continuously generates new neurons throughout life. Neural stem cells (type B1 cells) along the lateral ventricle become activated, self-renew, and give rise to proliferating precursors which progress along the neurogenic lineage from intermediate progenitors (type C cells) to neuroblasts (type A cells). Neuroblasts proliferate and migrate into the olfactory bulb and differentiate into different interneuronal types. Multiple factors regulate each step of this process. Newly generated olfactory bulb interneurons are an important relay station in the olfactory circuits, controlling social recognition, reproductive behavior, and parental care. Those behaviors are strongly sexually dimorphic and changes throughout life from puberty through aging and in the reproductive age during estrous cycle and gestation. Despite the key role of sex hormones in regulating those behaviors, their contribution in modulating adult neurogenesis in V-SVZ is underestimated. Here, we compare the literature highlighting the sexual dimorphism and the differences across the physiological phases of the animal for the different cell types and steps through the neurogenic lineage.

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