Hormones and Sex Behavior

Vignozzi, Linda; Maseroli, Elisa

doi:10.1007/978-3-030-03594-5_6-2

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…However, androgens recently came back into the spotlight as pivotal regulators of female sexual health. Indeed, preclinical and clinical studies have been constantly indicating that estrogens and androgens exert a synergic, stimulatory effect on the female sexual response, promoting sexual desire through a complex network of neurotransmitters and balance between excitatory and inhibitory signals [1]. It is worth noting that testosterone circulates at higher concentrations than estradiol during both pre- and postmenopausal years [15].…”

Section: Menopause and Sexual Functionmentioning

confidence: 99%

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Sexual Health in Menopause

et al. 2019

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Sexual function worsens with advancing menopause status. The most frequently reported symptoms include low sexual desire (40-55%), poor lubrication (25-30%) and dyspareunia (12-45%), one of the complications of genitourinary syndrome of menopause (GSM). Declining levels of sex steroids (estrogens and androgens) play a major role in the impairment of sexual response; however, psychological and relational changes related with aging and an increase in metabolic and cardiovascular comorbidities should also be taken into account. Although first-line therapeutic strategies for menopause-related sexual dysfunction aim at addressing modifiable factors, many hormonal and non-hormonal, local and systemic treatment options are currently available. Treatment should be individualized, taking into account the severity of symptoms, potential adverse effects and personal preferences.

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Section: Menopause and Sexual Functionmentioning

confidence: 99%

“…The concept of multidimensionality of sexuality is all the more true in the female gender. Indeed, the sexual response in women is particularly complex, due to an elaborate interplay of neuroemotional responses, pursuit of relational intimacy and dramatic fluctuations in hormonal levels [1].…”

Section: Introductionmentioning

confidence: 99%

Sexual Health in Menopause

et al. 2019

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Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts

Ticiani

Gingrich

et al. 2021

Environ Health Perspect

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Background: Bisphenol S (BPS) is an endocrine-disrupting chemical and the second most abundant bisphenol detected in humans. In vivo BPS exposure leads to reduced binucleate cell number in the ovine placenta. Binucleate cells form by cellular fusion, similar to the human placental syncytiotrophoblast layer. Given that human placental syncytialization can be stimulated through epidermal growth factor (EGF), we hypothesized that BPS would reduce human cytotrophoblast syncytialization through disruption of EGF receptor (EGFR) signaling. Objective: We tested whether BPS interferes EGFR signaling and disrupts human cytotrophoblast syncytialization. Methods: We first tested BPS competition for EGFR using an EGF/EGFR AlphaLISA assay. Using human primary term cytotrophoblast cells (hCTBs) and MDA-MD-231 cells, a breast cancer cell line with high EGFR expression, we evaluated EGFR downstream signaling and tested whether BPS could inhibit the EGF response by blocking EGFR activation. We also evaluated functional end points of EGFR signaling, including EGF endocytosis, cell proliferation, and syncytialization. Results: BPS blocked EGF binding in a dose-dependent manner and reduced EGF-mediated phosphorylated EGFR in both cell types. We further confirmed that BPS acted as an EGFR antagonist as shown by a reduction in EGF internalization in both hCTBs and MDA-MD-231 cells. Finally, we demonstrated that BPS interfered with EGF-mediated cell processes, such as cell proliferation in MDA-MD-231 cells and syncytialization in hCTBs. EGF-mediated, but not spontaneous, hCTB syncytialization was fully blocked by BPS ( ), a dose within urinary BPS concentrations detected in humans. Conclusions: Given the role of EGFR in trophoblast proliferation and differentiation during placental development, this study suggests that exposures to BPS at environmentally relevant concentrations may result in placenta dysfunction, affecting fetal growth and development. https://doi.org/10.1289/EHP7297

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Hormones and Sex Behavior

Cited by 2 publications

References 71 publications

Sexual Health in Menopause

Sexual Health in Menopause

Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts

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