Hormones and gynecologic cancer

Gurpide, Erlio

doi:10.1002/1097-0142(197607)38:1<503::aid-cncr2820380174>3.0.co;2-v

Cited by 19 publications

(2 citation statements)

References 31 publications

(2 reference statements)

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“…The highest concentrations were found to be 3.15 ng/ml. This is too high to be of extra-ovarian origin (Gurpide, 1976). The peak occurred at the same time that oestradiol plasma levels increased.…”

Section: Discussionmentioning

confidence: 91%

Return of Ovarian Function After Abortion

Lähteenmäki

Luukkainen

1978

Clinical Endocrinology

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The first menstrual cycle after a therapeutic abortion was studied in eighteen women by measuring plasma oestradiol and progesterone concentrations and the urinary excretion of LH until the first menstruation. The plasma concentrations of oestradiol and progesterone declined rapidly, reaching low values as early as the second day after the abortion. An increase in plasma oestradiol levels was observed from the seventh post-abortal day onwards. P peak of short duration in the plasma progesterone concentrations occurred during the increased oestradiol synthesis. The concentration of progesterone during the luteal phase of the cycle was lower than in a normal cycle, indicating an inadequate luteal function. Return of ovulation was observed in 83% of patients during the first cycle; as judged by a biphasic oestradiol profile in plasma, a mid-cycle LH peak, and subsequent elevation of progesterone. The first LH peak was observed 16 days after the abortion. The rapid return of the ovulatory function makes immediate post-abortal contraception a necessity.

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Section: Discussionmentioning

confidence: 91%

Return of Ovarian Function After Abortion

Lähteenmäki

Luukkainen

1978

Clinical Endocrinology

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“…Progesterone, which decreases in amount at the time of menopause, has an effect on the uterus and mammary tissue, where it interferes with estradiol activity (4, 5). Other activities of progesterone are not germane to our discussion.…”

Section: Possible Beneficial Effects Of Estrogen or Progesterone Therapymentioning

confidence: 99%

Hormones: Beneficial or Dangerous to the Aged?

Longcope

1978

J American Geriatrics Society

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Postmenopausal women lose 75-85 percent of estrogen and progesterone production compared with that in their reproductive years. The marked decrease in estrogen results in changes in the uterus, cervix, vaginal lining, glandular breast tissue, and the rate at which bone loses thickness. Some of these changes result in symptoms which range from unpleasant to disabling. Many of the symptoms can be alleviated by treatment with estrogens. However, recent reports have been linking estrogen usage with carcinoma of the uterus. Postmenopausal women should be treated with estrogens when the situation demands, but the dosage should be kept as low as possible and progestational agents should also be administered.

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The endocrinology of breast cancer

Korenman¹

1980

Cancer

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Endocrine studies relating to breast cancer are reviewed and the conclusion is reached that studies of hormone levels and hormone excretion to date are inconsistent and inadequate to explain the epidemiologic characteristics of the disease. A new paradigm termed the "estrogen window hypothesis" is introduced. Breast cancer risk is related to the duration of unopposed estrogen exposure during puberty and the early postmenarchial period and during the perimenopausal period. These two estrogen windows provide periods of maximum inducibility by environmental carcinogens. The hypothesis is supported by studies of the survivors of the atomic bomb blasts in Hiroshima and Nagasaki and of women having repeated fluoroscopy for management of tuberculosis. The hypothesis generates many testable conclusions. If verified, the hypothesis could lead to significant public health initiatives.

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Hormones and gynecologic cancer

Abstract: Available basic information about the regulation of rates of production, blood levels, intracellular metabolism, and action of steroid hormones and prolactin is reviewed and related to high-risk factors and therapeutic procedures applicable to gynecologic cancer.

Cited by 19 publications

References 31 publications

Return of Ovarian Function After Abortion

Return of Ovarian Function After Abortion

Hormones: Beneficial or Dangerous to the Aged?

The endocrinology of breast cancer

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