Hormones and growth factors regulate telomerase activity in ageing and cancer

Bayne, Sharyn Leanne; Liu, Junping

doi:10.1016/j.mce.2005.05.009

Cited by 107 publications

(97 citation statements)

References 113 publications

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“…Among different hormones and growth factors, TGF-β appears to be the only potent inhibitory growth factor that inhibits telomerase in cell cultures under physiologically relevant conditions [38]. The levels of TGF-β are inversely correlated with the levels of telomerase activity [5].…”

Section: Tgf-β Regulation Of Telomerase Activitymentioning

confidence: 99%

TGF-β and cancer: Is Smad3 a repressor of hTERT gene?

Toh

et al. 2006

Cell Res

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Section: Tgf-β Regulation Of Telomerase Activitymentioning

confidence: 99%

TGF-β and cancer: Is Smad3 a repressor of hTERT gene?

Toh

et al. 2006

Cell Res

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“…Several motifs in the R and RB domains of hTERT are conserved in different species, important for various molecular interactions [41,[46][47][48]. As the rate-limiting component of telomerase, hTERT induces immortalization of a number of cell types in culture [49] (reviewed in [50]). Recently, hTERT has also induced an immortalized nasopharyngeal epithelial cell line from non-malignant nasopharyngeal biopsies, which is accompanied by other genetic alterations seen in NPC including homozygous deletion of the p16 INK4A [12].…”

Section: Telomeres Telomerase and Cell Immortalizationmentioning

confidence: 99%

“…Most noteworthy of these levels of regulation is hTERT transcription. The hTERT promoter encompasses binding sites for various transcriptional regulators including c-myc, Sp1, p53, ETS and oestrogen (E2) receptor [50]. Complex interactions between distinct transcription factors and the hTERT gene promoter enable activation of the hTERT gene transcription and thereby telomerase activation in response to a wide variety of environmental factors and signalling pathways (Figure 2).…”

Section: Molecular Mechanisms Regulating Telomerase Activitymentioning

confidence: 99%

Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

et al. 2006

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Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China and Southeast Asia. The disease is a poorly differentiated carcinoma without effective cure, and the mechanism underlying its development remains largely unknown. Of several factors identified in NPC aetiology in recent years, Epstein-Barr virus (EBV) infection has emerged to be most important. In almost all NPC cells, EBV uses several intracellular mechanisms to cause oncogenic evolution of the infected cells. One such mechanism by which EBV infection induces cellular immortalization is believed to be through the activation of telomerase, an enzyme that is normally repressed but becomes activated during cancer development. Studies show that greater than 85% of primary NPC display high telomerase activity by mechanisms involving EBV infection, consistent with the notion that EBV is commonly involved in inducing cell immortalization. More recently, different EBV proteins have been shown to activate or inhibit the human telomerase reverse transcriptase gene, by modulating intracellular signalling pathways. These findings suggest a new model with a number of challenges towards our understanding, molecular targeting and therapeutic intervention in NPC.

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“…Due to the important role of telomerase in the cell cycle, the activity of the enzyme strongly correlates with the proliferative potential of the cells (Bayne and Liu, 2005). It was shown that granulosa cells with high proliferative potential were characterised by a higher telomerase activity level in comparision with those which were more differentiated (Lavranos et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The level of telomerase activity strongly correlates with the proliferation and differentiation status of the cell (Greider, 1998;Bayne and Liu, 2005). Lavranos et al (1999) showed that the level of telomerase activity was highest in the granulosa cells the least differentiated in lineage (from preantral follicles).…”

mentioning

confidence: 99%

Effect of aromatase inhibitor (fadrozole) on proliferation, estradiol production and telomerase activity in pig granulosa cells in vitro

Chronowska¹,

Tománek²,

Kott³

2009

CZECH J ANIM SCI

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ABSTRACT:The objective of the present work was to study the effect of a nonsteroidal aromatase inhibitor (fadrozole) on proliferation, estradiol production, aromatase expression and telomerase activity (TA) in pig granulosa cells (GC) from small (1-2 mm) and large (5-7 mm) follicles. The cells were treated with fadrozole for 48 h and 72 h in basal and FSH-stimulated conditions. Fadrozole caused a decrease (P < 0.05) of 3 H-thymidine incorporation in granulosa cells derived from small (1-2 mm) and large follicles (5-7 mm). The proliferative potential of small-follicle GC was significantly higher (P < 0.01) under all culture conditions. Estradiol production was suppressed (P < 0.01) in both granulosa cell populations cultured in the presence of fadrozole for 48 and 72 h. Fadrozole caused a decrease (P < 0.05) of aromatase gene expression in small-follicle granulosa cell incubated for 72 h and in large-follicle GC after 48 h of culture. Large-follicle GC were characterized by a higher (P < 0.01) level of estradiol production and aromatase gene expression. Telomerase activity decreased (P < 0.05) in large-follicle granulosa cells incubated in the presence of an aromatase inhibitor for 72 h. The TA level in large-follicle granulosa cells was higher (P < 0.01) in comparison to small-follicle GC in all culture conditions after 72 h of incubation. The results of the present study suggest the important role of telomerase in the process of follicular growth and development.

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Hormones and growth factors regulate telomerase activity in ageing and cancer

Cited by 107 publications

References 113 publications

TGF-β and cancer: Is Smad3 a repressor of hTERT gene?

TGF-β and cancer: Is Smad3 a repressor of hTERT gene?

Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma

Effect of aromatase inhibitor (fadrozole) on proliferation, estradiol production and telomerase activity in pig granulosa cells in vitro

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