Hormones and Breathing

Saaresranta, Tarja; Polo, Olli

doi:10.1378/chest.122.6.2165

Cited by 166 publications

(117 citation statements)

References 233 publications

(243 reference statements)

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“…The role of progesterone as a potent respiratory stimulant in the physiological regulation of breathing has been recently emphasized (37); in fact, it has been demonstrated that progesterone is able to increase sensitivity of the respiratory center to CO 2 (37,38). Thus, the increase of progesterone levels in hypoxic conditions at HA could be viewed as a stimulus for the respiratory drive; this would be favored by the decline in testosterone levels that are known to exert reduced down-regulation of progesterone receptors (37).…”

Section: Discussionmentioning

confidence: 99%

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Benso

Broglio

Aimaretti

et al. 2007

European Journal of Endocrinology

106

103

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Context: Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. Objective: To further investigate the endocrine and metabolic responses to extreme HA. Methods: We studied nine male elite climbers at sea level and at 5200 m after climbing Mt. Everest. Results: After 7 weeks at HA, body weight was reduced (P!0.05); regarding endocrine variables we observed: a) an increase of 2-h mean GH concentration (P!0.05) as well as of total IGF-I and IGF binding protein-3 levels (P!0.05 for both); b) a prolactin increase (P!0.05) coupled with testosterone decrease (P!0.01) and progesterone increase (P!0.05) without any change in estradiol levels: c) no change in cortisol, ACTH, and dehydroepiandrosterone sulfate (DHEAS) levels; d) an increase in free thyroxine (P!0.05) and free tri-iodothyronine (T 3 ) decrease (P!0.05) but no change in TSH levels; e) a plasma glucose decrease (P!0.05) without any change in insulin levels; f) an increase in mean free fatty acid levels (P!0.05); g) despite body weight loss, leptin levels showed non-significant trend toward decrease, while ghrelin levels did not change at all. Conclusions:The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T 3 syndrome but no change in ghrelin and leptin that was expected taking into account body weight decrease. These findings would contribute to better understanding human endocrine and metabolic physiology in hypoxic conditions. European Journal of Endocrinology 157 733-740

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Section: Discussionmentioning

confidence: 99%

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Benso

Broglio

Aimaretti

et al. 2007

European Journal of Endocrinology

106

103

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show abstract

“…Thyroid hormone is one of the hormone affects respiration, centrally as well as locally and respiratory functions can be affected by deficiency as well as excess secretion of thyroid hormone. [14][15][16] Hypothyroidism is associated with diminished ventilatory drive for both hypoxia and hypercapnia. [17,18] Supporting studies shown no change between the treated hypothyroid group and euthyroid group, explain that hormonal therapy can reverse the respiratory changes.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of airway functions in untreated hypothyroidism

Purohit¹,

Shah²,

Harsoda³

2017

Int J Med Sci Public Health

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“…Но по-чему женщины в целом реже страдают СОАС? Известно, что прогестерон и эстрадиол оказывают стимулирующее действие на дыхательный центр [11]. Это позволяет ком-пенсировать действие других факторов риска.…”

Section: синдром апноэ во снеunclassified

The diagnosis and treatment of sleep disorders: Role of melatonin

Burchakov¹

2015

Ross. vestn. akush.-ginekol.

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Hormones and Breathing

Cited by 166 publications

References 233 publications

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Endocrine and metabolic responses to extreme altitude and physical exercise in climbers

Dynamics of airway functions in untreated hypothyroidism

The diagnosis and treatment of sleep disorders: Role of melatonin

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