Hormones and Antioxidant Defense

Petrović, Vojislav M.; Saičić, Zorica S.; Spasić, Mihajlo; Radojičić, R.; Buzadžić, Biljana

doi:10.1007/978-1-4615-3850-9_57

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…This may be due to the specific effects exerted by glucocorticoids in different tissues. Moreover, it has been reported that hormones modulate the activities of antioxidant enzymes in 'tissue specific manners', and that enzyme regulation is closely connected with the dominant metabolic activity (Petrovic et al, 1991). Thus, variations exhibited by organs depend on two factors: (a) the dominant metabolic activity of the tissue under investigation, and (b) the levels and numbers of receptors in a particular tissue.…”

Section: Discussionmentioning

confidence: 99%

Oxidative status of DBA/1J mice with type II collagen‐induced arthritis

Choi

2007

J of Applied Toxicology

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The present study was undertaken to compare the oxidant statuses of mice with collagen-induced arthritis (CIA) and those of healthy mice. For this purpose, serum oxidant products and arthritic profiles were measured in DBA/1J mice with CIA. In addition, the levels of oxidation products and the activities of antioxidant enzymes were determined in liver, heart, spleen, kidney, lung and brain. The induction of arthritis significantly increased anti-collagen antibody, rheumatoid factor, interleukin (IL)-1beta, IL-6, protein carbonyl (PCO), advanced glycation end-products (AGE), malondialdehyde (MDA) and low density lipoprotein (LDL)-cholesterol levels in serum (P < 0.05). CIA in DBA/1J mice was associated with significantly lower activities of superoxide dismutase, glutathione peroxidase and glutathione reductase in spleen but higher levels of oxidation products in spleen, kidney and liver than healthy normal mice (P < 0.05). However, lower concentrations of oxidized protein and higher activities of antioxidant enzymes were observed in CIA mouse lung and brain than in healthy normal mice. Dexamethasone treated CIA mice had decreased arthritis-related indices and showed: reduced PCO and AGE in spleen and brain, and increased PCO and AGE in heart, kidney and lung; increased MDA in heart, spleen, lung and brain; reduced SOD and GR activities in lung and brain; increased GPx activity in spleen and brain; and increased GR activity heart and spleen. These data suggest that mice with CIA were more susceptible to oxidative damage in the spleen and liver under the chronic inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Oxidative status of DBA/1J mice with type II collagen‐induced arthritis

Choi

2007

J of Applied Toxicology

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Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats

Pajović¹,

Saičić

Spasić

et al. 1996

Experientia

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The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 micrograms estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.

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Modulation of antioxidant enzyme activities by sexual steroid hormones

Saičić²

2008

Physiol Res

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Taking into consideration the biological importance of interaction between antioxidant defense (AD) enzymes and sexual steroid hormones it was deemed important to compare our recent achievements in the field with the state of current knowledge. The main goal of the present review was to investigate the changes of AD enzyme activities: superoxide dismutases, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase in the brain of female and male rats depending on progesterone and estradiol. These ovarian steroids produce their effects by acting on numerous target tissues and organs, such as the reproductive organs, bone tissue and cartilage, peripheral blood vessels and the central nervous system (CNS). We have chosen it as a new parameter that might represent an important indicator of the changes within the CNS, bearing in mind the biological importance of the enzymes of the AD system. Our experimental results indicate that the AD enzyme activities in the brain tissue of female and male rats show a certain dependence on the concentration of progesterone and estradiol. The present review suggests that the modulation of the oxidative and antioxidative capacity by sexual steroid hormones is mediated through antioxidant metabolizing enzymes.

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Hormones and Antioxidant Defense

Cited by 3 publications

References 17 publications

Oxidative status of DBA/1J mice with type II collagen‐induced arthritis

Oxidative status of DBA/1J mice with type II collagen‐induced arthritis

Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats

Modulation of antioxidant enzyme activities by sexual steroid hormones

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