Hormone supply to the pituitary gland: A comprehensive investigation of female‑related tumors (Review)

Tian, Wenxiu; Qi, Huimin; Wang, Zhimei; Qiao, Songlin; Wang, Ping; Dong, Jun; Wang, Hongmei

doi:10.3892/ijmm.2022.5178

Cited by 3 publications

(2 citation statements)

References 158 publications

(160 reference statements)

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“…The dysregulation of hormones is frequently associated with cancer initiation and progression (15). The hypothalamus-hypophysis axis, which controls the production and secretion of hormones through the pituitary portal vein system, regulates various physiological functions of the body (16). Here, we examined the expression of relevant receptors in colitis-associated cancer (CAC) using the GEO database and found that the expression of GHRHR and OXTR genes was decreased (Figure . 1A).…”

Section: Iecs Ablation Of Oxtr Sensitizes Mice To Cacmentioning

confidence: 99%

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

Wang,

chen,

guo

et al. 2023

Preprint

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Colon cancer is commonly regarded as hormone-independent. However, there have been reports suggesting the involvement of sex hormones in colon cancer development. Nevertheless, the role of hormones from the hypothalamus-hypophysis axis in colitis-associated colorectal cancer (CAC) remains uncertain. In this study, we observed a significant reduction in the expression of the oxytocin receptor (OXTR) in colon samples from both colitis and CAC patients. To investigate further, we generated mice with an intestinal epithelium cell (IEC)-specific knockout of OXTR. These mice exhibited markedly increased susceptibility to dextran sulfate sodium (DSS)-induced colitis and DSS/Azoxymethane (AOM)-induced CAC compared to wild-type mice. Our findings indicate that OXTR depletion impaired the inner mucus of the colon epithelium. Mechanistically, oxytocin was found to regulate MUC2 maturation through B3GNT7-mediated fucosylation. Interestingly, we observed a positive correlation between B3GNT7 expression and OXTR expression in human colitis and CAC colon samples. Moreover, the administration of oxytocin significantly alleviated tumor burden. Hence, our study unveils oxytocin's promising potential as an affordable and effective therapeutic intervention for individuals affected by colitis and CAC.

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Section: Iecs Ablation Of Oxtr Sensitizes Mice To Cacmentioning

confidence: 99%

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

Wang,

chen,

guo

et al. 2023

Preprint

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“…The hypothalamic-pituitary axis is known to be affected by hypoxia, hypercoagulability, endothelial dysfunction and autoimmune changes caused by various infectious and non-infectious diseases [12]. In general, the hormonal regulation of the hypothalamic-pituitary function is extremely complex and integrates several regulatory levels, ranging from the subcellular to extracellular processes [13].…”

Section: Introductionmentioning

confidence: 99%

Features of changes in the content of hormones of the hypothalamic-pituitary tract depending on the independent or combined variant of B16/F10 melanoma growth in mice of both sexes

Frantsiyants¹,

Bandovkina²,

Kaplieva³

et al. 2023

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The aim of our research work was to study changes in the level of hormones of the hypothalamus and pituitary gland in mice of both sexes in different variants of the B16/F10 melanoma growth. BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14); a reference group of mice of both sexes with standard subcutaneous B16/F10 melanoma inoculation (n=14); the main group of mice (n=14) where B16/F10 melanoma and Lewis carcinoma were inoculated into the mice sequentially subcutaneously on two sides: one on the left side, the other on the right side. At the terminal stage of the tumor growth, with ELISA using standard kits in 1% hypothalamic tissue homogenates we determined contents of releasing hormones as follows: corticotropic hormone (CRH), thyrotropic hormone (TRH), gonadotropic hormone (GnRH), somatotropic hormone (STH-R); in the pituitary with RIA determined were TSH, LH, FSH and ACTH (Immunotech, Czech Republic). Results. In males and females of both groups, the level of TRH in the hypothalamus decreased by 9-3.7 times, and only in females of the main group, the level of TSH in the pituitary gland increased by 2.8 times. Other releasing peptides in the hypothalamus of females increased by 1.9-6 times, while in males they decreased by 1.4-7 times. In the pituitary gland in males of both groups, the level of LH increased by 1.3-1.4 times and ACTH by 2.5-4 times, but FSH decreased by 7.8-13.6 times. In females, the level of FSH and ACTH in the pituitary gland decreased by 1.5 times – 1.8 times (р˂0.05), only in the main group the content of TSH increased by 2.8 times and only in the reference group LH by 1.6 times (р˂0.05). Conclusion. With the development of B16/F10 melanoma, there was a sex-dependent dysfunction of the hypothalamic-pituitary tract. Changes in the concentrations of GnRH, CRH, and STH-R in the hypothalamus in different directions in males and females indicate different mechanisms of hormonal imbalance in response to the growth of a malignant tumor.

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The impact of brain tumor location and treatment on sexual function: Implications for clinical practice

N. Gatson,

Milbourne,

Ornelas

et al. 2024

Neuropsychological and Psychosocial Foundations of Neuro-Oncology

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Hormone supply to the pituitary gland: A comprehensive investigation of female‑related tumors (Review)

Cited by 3 publications

References 158 publications

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

Features of changes in the content of hormones of the hypothalamic-pituitary tract depending on the independent or combined variant of B16/F10 melanoma growth in mice of both sexes

The impact of brain tumor location and treatment on sexual function: Implications for clinical practice

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