Hormone Replacement Therapy Is Associated With Decreased Survival in Women With Lung Cancer

Ganti, Apar Kishor; Sahmoun, Abe E.; Panwalkar, Amit; Tendulkar, Ketki; Potti, Anil

doi:10.1200/jco.2005.02.9827

Cited by 177 publications

(127 citation statements)

References 20 publications

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“…Unfortunately 58% of these patients will be diagnosed from developing countries (Brownson et al, 1992, Taioli 1994, Darby et al, 2001, Grupta et al, 2001, Lissowska et al, 2005, Darby et al, 2006, Ganti et al, 2006, Schrump et al, 2008, Ferlay et al, 2010, Bouchardy et al, 2011, Raùl Barrera-Rodriguez 2012. Although lung cancer is more frequent among men, it is a major threat to women today.…”

Section: Discussionmentioning

confidence: 99%

“…Smoking is the major risk factor for both genders. Other risk factors that can cause lung cancer among non smokers are passive smoking, radon, exposure to asbestos, occupational exposures, hormones and genetic factors (Brownson et al, 1992, Taioli 1994, Darby et al, 2001, Grupta et al, 2001, Lissowska et al, 2005 Ganti et al, 2006, Schrump et al, 2008, Ferlay et al, 2010, Bouchardy et al, 2011, Raùl Barrera-Rodriguez 2012. In this study, we present the clinical, pathological and survival datas of 50 female patients with lung cancer who were treated in our center.…”

Section: Introductionmentioning

confidence: 99%

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Lung Cancer in Women: A Single Institution Experience with 50 Patients

Babacan

Yücel²,

Kılıçkap³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Lung cancer is the most common cause of cancer-related death worldwide. The incidence of lung cancer is aproximately 7-8 thousand percent in Turkish women. In this study, we aimed to evaluate the clinical, pathological properties and survival data of female patients with lung cancer who were treated in our center. Materials and Methods: From 2007 to 2012, 50 women with lung cancer were enrolled. Patient data were evaluated retrospectively. Results: The median age was 61 (40-81). Forty patients (80%) were diagnosed with non small cell lung cancer (NSCLC), 10 patients (20%) were small cell carcinoma (SCC). Twelve (24%) patients were smokers and 13 of 16 non-smokers had a history of exposure to asbestos. The most common histologic subtype was adenocarcinoma (46%) and this accounted for 71% in patients with exposure to asbestos. The most common initial Eastern Cooperative Oncology Group (ECOG) performance score was 1 (24 patients, 48%) and initial stage was IV (25 patients, 50%) in the study group. During the median 15 months (1-96 months) follow up period: 1 year overall survival (OS) was 68%, 2 year overall survival was 36% and the median survival time was 19 months. According to univariate analysis, poor ECOG performance status, advanced stage, anemia and weight loss at time of diagnosis were negative prognostic factors. However, adenocarcinoma sub-type was a positive prognostic factor. Conclusions: In this study NSCLC sub-type, poor ECOG performance score, advanced stage, anemia and weight loss were prognostic factors in Turkish women with lung cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lung Cancer in Women: A Single Institution Experience with 50 Patients

Babacan

Yücel²,

Kılıçkap³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

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“…Авторы установили также, что раннее (до 40 лет включительно) наступление менопаузы ассоциировано со снижением риска возникновения аденокарциномы легкого [19]. Результаты другого исследования подтвер-дили эти данные и показали, что гормонозаместительная терапия эстрогенами ухудшает показатели выживаемости у женщин, больных раком легкого [20].…”

Section: экспрессия эстрогеновых рецепторов в ткани немелкоклеточногоunclassified

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

et al. 2012

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“…Previous studies showed that a great majority of NSCLC expressed ERs (5 -8) and estrogen stimulated the growth of NSCLC tumors in nude mouse xenografts. In addition, hormone replacement therapy has been reported to significantly decrease survival in women with lung cancer (9). Therefore, estrogenic actions have been postulated to contribute to the development and/or progression of NSCLC.…”

mentioning

confidence: 99%

Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma

Niikawa

Suzuki²,

Miki

et al. 2008

Clinical Cancer Research

175

213

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Purpose: The possible involvement of gender-dependent factors has been suggested in human non-small cell lung carcinomas (NSCLC), but their precise roles remain largely unclear. Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC. Experimental Design: Fifty-nine frozen specimens of NSCLC were available for liquid chromatography/electrospray tandem mass spectrometry to study intratumoral estradiol concentrations. In addition, A549 NSCLC cells stably expressing estrogen receptor (ER) a (A549 + ERa) or ERh (A549 + ERh) were used in vitro studies. Results: Forty-three (73%) of 59 NSCLC showed higher concentration of estradiol in carcinoma tissues than the corresponding nonneoplastic lung tissues from the same patient, and intratumoral estradiol concentrations were significantly (P = 0.0002 and 2.2-fold) higher than the corresponding nonneoplastic lungs. The intratumoral concentration of estradiol was positively correlated with aromatase expression, tumor size, and Ki-67 status in ERa-or ERh-positive cases. In in vitro studies, estradiol significantly increased cell proliferation of A549 + ERa orA549 + ERh, which was significantly suppressed by selective ER modulators, tamoxifen or raloxifene. Both A549 + ERa and A549 + ERh cells expressed aromatase. The cell proliferation level in these cells was significantly increased under treatment with testosterone, and it was inhibited by addition of the aromatase inhibitor letrozole. Conclusions: These results suggest that estradiol is locally produced in NSCLC mainly by aromatase and plays an important role in the growth of ERa-or ERh-positive NSCLC. Therefore, use of selective ER modulators and/or aromatase inhibitors may be clinically effective in NSCLC that are positive for both ER and aromatase.

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Hormone Replacement Therapy Is Associated With Decreased Survival in Women With Lung Cancer

Abstract: HRT may affect outcomes from lung cancer adversely. Further studies examining the role of HRT use on outcomes from lung cancer, especially in women with a history of smoking, are urgently needed to clarify this important problem.

Cited by 177 publications

References 20 publications

Lung Cancer in Women: A Single Institution Experience with 50 Patients

Lung Cancer in Women: A Single Institution Experience with 50 Patients

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

Intratumoral Estrogens and Estrogen Receptors in Human Non–Small Cell Lung Carcinoma

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