Hormone Replacement Therapy in the Menopause: A Suitable Animal Model

Papadaki, L; Beilby, J. O. W.; Chowaniec, J.; Coulson, Walter F.; Darby, A. J.; Newman, Jan B.; O’Shea, Alan; Wykes, J. R.

doi:10.1677/joe.0.0830067

Cited by 14 publications

(2 citation statements)

References 26 publications

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“…Hysterectomy is the usual method of treatment, particularly in older women. The importance of estrogen is also suggested by studies in animals in which administration of estrogens has produced endometrial cancer ( 129). The important role estrogens play in the etiology of endometrial cancer has long been recognized (104).…”

Section: Ovarian Cancer and Neoplasms Of The Female Genital Tractmentioning

confidence: 99%

Antitumor Effects of Analogs of Hypothalamic Hormones in Endocrine-Dependent Cancers

Schally¹,

Comaru‐Schally²,

Redding³

1984

Experimental Biology and Medicine

132

106

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Section: Ovarian Cancer and Neoplasms Of The Female Genital Tractmentioning

confidence: 99%

Antitumor Effects of Analogs of Hypothalamic Hormones in Endocrine-Dependent Cancers

Schally¹,

Comaru‐Schally²,

Redding³

1984

Experimental Biology and Medicine

132

106

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“…Under such conditions, the endometrium is stimulated and hyperplastic changes sometimes accompanied by neoplastic transformation take place. Estrogens have thus been postulated to function as putative carcinogenic or co-carcinogenic agents (De Grouchy, 1973;Ayre and Bauld, 1946;Sommers and Meissner, 1957;Meissner et al, 1957;Papadaki et al, 1979).…”

mentioning

confidence: 99%

The immune system during the pre‐cancer and the early cancer period. IL‐2 production by PBL from post‐menopausal women with and without endometrial carcinoma

Yron

Schickler

Fisch

et al. 1986

Intl Journal of Cancer

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We report on alterations in IL-2 production and cell proliferation following PHA stimulation of peripheral blood lymphocytes (PBL) from stage-I endometrial carcinoma (EC) patients, and on mechanisms involved in these alterations. Our study includes 3 groups: EC patients, post-menopausal women at high risk of developing EC, and age-matched healthy women. IL-2 production was markedly lower in most EC patients than in healthy controls. Varying levels of IL-2 were produced by PBL from women in the high-risk group. The proliferative response of PBL to PHA appeared to correlate with levels of IL-2 production. Our results suggest that macrophages are involved, in part, in the modulation of T-cell functions of EC patients.

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Location of inclusion cysts in mouse ovaries in relation to age, pregnancy, and total ovulation number: implications for ovarian cancer?

2005

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Benign ovarian cysts are thought to be precursor lesions that differentiate and transform into carcinoma. With the aim of testing the hypothesis that increased ovulation number increases the frequency or number of ovarian cysts, the development and appearance of ovarian cysts was investigated in mice of differing ages and total lifetime ovulation number. High total ovulation number was induced by keeping mice in cages divided by a screen, with a male on one side and two females on the other side. Significantly more cysts were observed in animals subjected to incessant ovulation for 8 months and in 12 month breeding mice than in 3-month virgin mice or 1-month prepubertal animals. These cysts had the appearance of benign serous inclusion cysts. When cystic ovaries were serial sectioned, 47% of cysts had a connection to the ovarian hilus and potentially to the tubules of the rete ovarii, 31% were adjacent to the hilus, and 22% had an intra-ovarian location. A significant increase in intra-ovarian cysts was observed in the 8-month incessant ovulation group, implying that high ovulation number leads to ovarian surface invagination and inclusion cyst formation. In conclusion, ovarian inclusion cysts may be derived from more than one epithelial source, but incessant ovulation may increase the proportion derived from the ovarian surface epithelium. Because the cysts observed resembled human serous inclusion cysts these results have possible implications for epithelial ovarian carcinoma.

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Hormone Replacement Therapy in the Menopause: A Suitable Animal Model

Cited by 14 publications

References 26 publications

Antitumor Effects of Analogs of Hypothalamic Hormones in Endocrine-Dependent Cancers

Antitumor Effects of Analogs of Hypothalamic Hormones in Endocrine-Dependent Cancers

The immune system during the pre‐cancer and the early cancer period. IL‐2 production by PBL from post‐menopausal women with and without endometrial carcinoma

Location of inclusion cysts in mouse ovaries in relation to age, pregnancy, and total ovulation number: implications for ovarian cancer?

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