Hormone Replacement Therapy and Lung Cancer Risk

Schabath, Matthew B.; Wu, Xifeng; Vassilopoulou‐Sellin, Rena; Vaporciyan, Ara A.; Spitz, Margaret R.

doi:10.1158/1078-0432.ccr-0911-3

Cited by 165 publications

(137 citation statements)

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“…25 Olsson et al demonstrated a reduced lung cancer risk in HRT ever users; long-term HRT use (48 months) was associated with a reduced risk of smoking-related cancers, including lung cancer. 26 Schabath et al 27 found HRT use within the previous 6 months was associated with a reduced lung cancer risk. In our study, we defined HRT use as ever use of HRT for 3 months or more, which is similar to the definition by Blackman et al 23 The association of HRT and reduced lung cancer risk could be found in studies with different durations of HRT use.…”

Section: Discussionmentioning

confidence: 99%

“…24 Conversely, several studies have demonstrated an inverse association between HRT use and lung cancer risk. [25][26][27] Because of the high female to male ratio of lung cancer patients in Taiwan and the frequent use of HRT in women for postmenopausal symptoms, the hypothesis that HRT may be associated with reduced lung cancer risk is of clinical importance and needs confirmation. In this study, we investigated whether HRT was associated with a reduced lung cancer risk in Chinese women.…”

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Hormone replacement therapy and lung cancer risk in Chinese

Chen¹,

Hsiao²,

Chang³

et al. 2007

Cancer

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Interaction between different toughening mechanisms is studied using a heat treated hybrid system, consisting of carboxyl‐terminated butadiene acrylonitrile (CTBN) rubber and EXPANCEL (expandable hollow microspheres) as modifiers for an epoxy resin. It was found that the fracture toughness of the hybrid system is higher than that of either individually EXPANCEL‐ or CTBN‐modified system for a given content of modifier, although the maximum toughness was not substantially high compared with maxima of single modifier systems. Microscopic examination revealed that damage zone due to CTBN particles ahead of the crack reduces due to the presence of EXPANCEL particles and nevertheless its fracture toughness increased. A possibility was deduced that the cavitation due to CTBN assists with promoting compressive stresses around EXPANCEL particles ahead of the crack tip, resulting in increase in fracture toughness. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 4470–4475, 2006

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Hormone replacement therapy and lung cancer risk in Chinese

Chen¹,

Hsiao²,

Chang³

et al. 2007

Cancer

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“…Eleven studies have reported on the association of HRT and risk of lung cancer. 18,19,21,22,[24][25][26]28,30,31,35 Most of these studies do not define whether their results pertain to estrogen alone or estrogen plus progestin. One early cohort study from Sweden, 19 which assessed exposure to both potent estrogens and weaker Each factor is adjusted for all other factors, including for parity (4 levels), age at menarche (4 levels), menopausal status (pre-, peri-and postmenopausal), oral contraceptive use (ever/never), hormone replacement use (ever/never), body mass index (continuous), education (3 categories), smoking status (never, former smoker and current smoker), pack-years of smoking (continuous), study center and randomization group (intervention versus control).-2 Among parous women.…”

Section: Discussionmentioning

confidence: 99%

“…A second cohort study from Sweden, 25 24 However, follow-up of this cohort was rather short (mean of 5.2 years). Of the remaining studies, in which the specific type of preparation was not defined, 2 studies reported statistically significant reductions in risk 28,35 ; one reported a nonsignificant reduction in risk 31 ; and 3 reported nonsignificant or borderline increases in risk. 18,21,30 Our result indicating that 10 years of HRT use is associated with modestly increased risk needs to be confirmed in other prospective studies.…”

Section: Discussionmentioning

confidence: 99%

Reproductive and hormonal factors and risk of lung cancer in women: A prospective cohort study

Kabat

Miller

Rohan

2007

Intl Journal of Cancer

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Several lines of evidence suggest that endocrine factors may play a role in the development of lung cancer, but the evidence is limited and inconsistent. We investigated the association of reproductive and hormonal factors with risk of lung cancer in the National Breast Screening Study, which included 89,835 Canadian women aged 40-59 years at recruitment between 1980 and 1985. Linkages to national cancer and mortality databases provided data on cancer incidence and deaths from all causes, respectively, with follow-up ending between 1998 and 2000. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between hormonal factors and lung cancer. During a mean of 16.4 years of follow-up, we observed 750 incident lung cancer cases. After adjustment for covariates, parous women were not at increased risk of lung cancer (HR 5 1.18, 95% CI 0.94-1.47) relative to nulliparous women; however, there was a modest increase in risk with increasing parity, reaching a HR of 1.42, 95% CI 1.06-1.88 in women who had 5 or more live births (p for trend 0.02). Among parous women, age at first live birth was inversely associated with risk. Women who had their first live birth at age 30 or older were at reduced risk relative to women who had their first live birth below age 23 (HR 0.68, 95% CI 0.50-0.93, p for trend 0.004). These associations did not differ by age at enrollment (40-49 vs. 50-59 years old), but were somewhat strengthened when attention was restricted to never smokers. Ever use of exogenous hormones showed little association with lung cancer risk; however, long-term users of hormone replacement therapy were at slightly increased risk. Our results add to the limited existing evidence that certain reproductive and hormonal factors may be associated with lung cancer risk in women. ' 2007 Wiley-Liss, Inc.Key words: lung neoplasms; reproductive factors; menstrual factors; exogenous hormones Although cigarette smoking accounts for the vast majority of lung cancer incidence, several other factors that may contribute independently to lung cancer risk or modify the effects of smoking have been proposed. 1 Several lines of evidence suggest that endocrine factors may play a role in the development of lung cancer in women, but the evidence is limited and inconsistent. A greater proportion of female than male lung cancer cases occurs in never smokers, and lung cancer is more likely to be adenocarcinoma in women than in men. 2,3 Estrogen receptors and other steroid receptors have been detected in both normal lung tissue and lung tumors, but their significance and their role in lung cancer are unclear. 4-10 Additionally, some studies, though not all, suggest that women are more susceptible to tobacco carcinogenesis than men. 11-16 A small number of mostly case-control studies have examined the association of various reproductive and hormonal factors with lung cancer, but the results have been inconsistent. [17][18][19][20][21][22][23][24][25][26][27][28] Several...

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“…Whether this finding was an effect of chance, confounders, a tumourrelated effect, or another cancer-related effect is unclear. Although estrogen replacement therapy has not shown a consistent effect on lung cancer incidence (and may even be slightly protective 13 ), the possible association of estrogen replacement therapy with an aggressive course of lung cancer was highly interesting.…”

Section: Introductionmentioning

confidence: 99%