Hormone receptor status of breast cancer in India: a study of 798 tumours

Desai, Sangeeta; Moonim, Mufaddal; Gill, Amarinder K.; Punia, Rajpal Singh; Naresh, Kikkeri N.; Chinoy, Roshni

doi:10.1054/brst.2000.0134

Cited by 112 publications

(115 citation statements)

References 6 publications

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“…However, few previous studies have evaluated differences in clinical and pathologic tumour characteristics by histologic type. With respect to ER/PR status, lobular, ductal/lobular, and mucinous carcinomas have been shown to be more likely to be ER þ /PR þ compared to ductal carcinomas, similar to what we observed here (Desai et al, 2000;Arpino et al, 2004;Korhonen et al, 2004;Mathieu et al, 2004). However, studies have not evaluated ER/PR status in rarer histologic types of breast cancer, or evaluated differences in stage, tumour size, lymph node status, or grade by histologic type.…”

Section: Discussionsupporting

confidence: 82%

Clinical characteristics of different histologic types of breast cancer

2005

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Breast cancer is a heterogeneous disease, though little is known about some of its rarer forms, including certain histologic types. Using Surveillance, Epidemiology, and End Results Program data on 135 157 invasive breast cancer cases diagnosed from 1992 to 2001, relationships between nine histologic types of breast cancer and various tumour characteristics were assessed. Among women aged 50 -89 years at diagnosis, lobular and ductal/lobular carcinoma cases were more likely to be diagnosed with stage III/IV, X5.0 cm, and node-positive tumours compared to ductal carcinoma cases. Mucinous, comedo, tubular, and medullary carcinomas were less likely to present at an advanced stage. Lobular, ductal/lobular, mucinous, tubular, and papillary carcinomas were less likely, and comedo, medullary, and inflammatory carcinomas were more likely to be oestrogen receptor (ER) negative/progesterone receptor (PR) negative and high grade (notably, 68.2% of medullary carcinomas were ERÀ/PRÀ vs 19.3% of ductal carcinomas). In general, similar differences were observed among women diagnosed at age 30 -49 years. Inflammatory carcinomas are associated with more aggressive tumour phenotypes, and mucinous, tubular, and papillary tumours are associated with less aggressive phenotypes. The histologic types of breast cancer studied here differ greatly in their clinical presentations, and the differences in their hormone receptor profiles and grades point to their likely different aetiologies. British Journal of Cancer (2005) Although breast cancer remains the most commonly diagnosed cancer among women in the United States (US) and worldwide, it is a heterogeneous disease. Breast cancer can be categorized in several ways, including based on its clinical features, its expression of tumour markers, and its histologic type. The two most common histologic types of invasive breast cancer are ductal and lobular carcinomas, accounting for approximately 75 and 15% of all cases in the US, respectively (Li et al, 2003a). Interest in lobular carcinoma in particular has recently been piqued by data indicating that incidence rates of lobular carcinoma are increasing more rapidly than are rates of ductal carcinoma in the US. Specifically, lobular rates have increased by 65% from 1987 to 1999, while rates of ductal carcinoma have increased only by 3% (Li et al, 2003a). Studies also suggest that lobular carcinomas are more likely than ductal carcinomas to be hormone receptor positive (Arpino et al, 2004;Korhonen et al, 2004). This difference may partly explain why seven studies have consistently observed that combined oestrogen and progestin postmenopausal hormone use is more strongly related to lobular carcinoma risk than to ductal carcinoma risk (Li et al, 2000(Li et al, , 2003bChen et al, 2002;Newcomb et al, 2002;Daling et al, 2003;Newcomer et al, 2003).While several studies have now examined the clinical, pathologic, and epidemiologic differences between ductal and lobular carcinomas, much less is known about the rarer histologic types of breast cancer,...

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Section: Discussionsupporting

confidence: 82%

Clinical characteristics of different histologic types of breast cancer

2005

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“…This is consistent with the findings from previous studies done in India, which also found a very high proportion of ER2 cases. 19 Similar results have also been seen from other countries in Asia, such as Pakistan, 20 China 21 and Japan. 22 One of the reasons put forth earlier for this observation has been younger age at presentation among Indian women, 19 although this may not be the only factor responsible.…”

Section: Discussionsupporting

confidence: 74%

“…Most studies that have looked at hormone receptor status in the recent past utilized secondary data and explored associations with limited number of clinical variables. 18,19 This has prevented effective extrapolation of those results at the population level. Indeed, there have been hardly any studies in India that have looked at the association of hormone receptor status of breast cancer and the underlying risk factors.…”

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confidence: 99%

Risk factors according to estrogen receptor status of breast cancer patients in Trivandrum, South India

Dey

Boffetta

Mathews

et al. 2009

Intl Journal of Cancer

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Estrogen receptor (ER) status is an important biomarker in defining subtypes of breast cancer differing in antihormonal therapy response, risk factors and prognosis. However, little is known about association of ER status with various risk factors in the developing world. Our case-control study done in Kerala, India looked at the associations of ER status and risk factors of breast cancer. From 2002 to 2005, 1,208 cases and controls were selected at the Regional Cancer Center (RCC), Trivandrum, Kerala, India. Information was collected using a standardized questionnaire, and 3-way analyses compared ER1/ER2 cases, ER1 cases/controls and ER2 cases/controls using unconditional logistic regression to calculate odds ratios and 95% confidence intervals. The proportion of ER2 cases was higher (64.1%) than ER1 cases. Muslim women were more likely to have ER2 breast cancer compared to Hindus (OR 5 1.48, 95% CI 5 1.09, 2.02), an effect limited to premenopausal group (OR 5 1.87, 95% CI 5 1.26, 2.77). Women with higher socioeconomic status were more likely to have ER1 breast cancer (OR 5 1.48, 95% CI 5 1.11, 1.98). Increasing BMI increased likelihood of ER2 breast cancer in premenopausal women (p for trend < 0.001). Increasing age of marriage was positively associated with both ER1 and ER2 breast cancer. Increased breastfeeding and physical activity were in general protective for both ER1 and ER2 breast cancer. The findings of our study are significant in further understanding the relationship of ER status and risk factors of breast cancer in the context of the Indian subcontinent. ' UICCKey words: estrogen receptor; breast cancer; India Estrogen receptor (ER) status of breast tumors has been instrumental in defining an important subtype of breast cancer with differences observed in risk factors, treatment and prognosis. [1][2][3][4][5][6][7] Numerous studies in the past have looked at differences in etiology and risk factors pertaining to presence or absence of ER-alpha. Most of these studies were conducted in Western populations as early as 1980s. [1][2][3][4][5] Around the same time, it was also discovered that ER1 tumors that lacked progesterone receptor (PR) expression were less responsive to endocrine therapy compared to tumors that expressed PR. 8 This led to studies in the past decade that looked at the link of various risk factors of breast cancer and combined ER/PR information to better explain the underlying differences between the various subtypes of breast cancer. 9-13 Chen and Colditz 14 have emphasized the importance of taking into account the ER/PR status information of breast tumors both for effective treatment as well as risk prediction for instituting prophylactic measures. Although there might be numerous ways to subtype breast cancer, the classification into ER1 and ER2 cancer remains a key divider. 14 However, information related to ER status is lacking for populations in developing countries. In fact, in most developing countries, determination of hormone receptor status is not a part of standard pro...

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“…Further, positivity of hormonal receptor was found more in infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma (ILC). Desai et al [26] also reported the higher positivity of hormonal receptors in IDC and ILC. The grade of tumor in our study was significantly inversely correlated with the expression of PR (P value 0.0006) whereas in previous studies, both ER and PR expression were significantly inversely correlated [9].…”

Section: Discussionmentioning

confidence: 90%

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

Dodiya¹,

Patel²,

Patel³

et al. 2013

Ind J Clin Biochem

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The objective of study was to evaluate and correlate the pathological characteristics of breast cancer patients with estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2/neu) detected by immunohistochemistry and/or fluorescent in situ hybridization method. We have conducted 2 year study of 204 cases of breast cancer at HCG-Medisurge Hospitals, Ahmedabad from 2009 to 2011. Significant correlation was found in ER and PR expression whereas no correlation was found in hormonal receptors and Her2/neu expression. ER and PR positivity increased with advancing age in breast carcinoma patients while not affecting Her2/neu expression. The expression of hormone receptors were higher in infiltrating lobular carcinoma and infiltrating duct carcinoma subtypes of breast carcinoma as compared to other subtypes such medullary and in situ carcinoma. High-grade carcinoma patients were predominantly ER/PR negative and Her2/neu positive as compared to lower grade breast carcinoma whereas high-stage carcinoma patients were ER/PR positive and Her2/neu positive as compared to lower stage breast carcinoma.

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Hormone receptor status of breast cancer in India: a study of 798 tumours

Cited by 112 publications

References 6 publications

Clinical characteristics of different histologic types of breast cancer

Clinical characteristics of different histologic types of breast cancer

Risk factors according to estrogen receptor status of breast cancer patients in Trivandrum, South India

Study of Hormone Receptors and Epidermal Growth Factor Expression in Invasive Breast Cancers in a Cohort of Western India

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