Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption

Ruiz, Thalles Fernando Rocha; Colleta, Simone Jacovaci; Zuccari, Débora Aparecida Pires de Campos; Vilamaior, Patrícia Simone Leite; Leonel, Ellen Cristina Rivas; Taboga, Sebastião Roberto

doi:10.1016/j.lfs.2021.120010

Cited by 10 publications

(14 citation statements)

References 104 publications

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“…In the available literature, a substantial amount of evidence can be found for the positive therapeutic effects of endocrine-active compounds on certain neoplastic processes, such as the prevention of osteoporosis or hormone replacement [ 60 , 61 , 62 , 63 ]. However, multiple studies report a negative impact or even direct responsibility of such compounds for occurrences of many cancers [ 64 , 65 , 66 , 67 , 68 ]. The effects of exogenous endocrine compounds present in the aquatic environment on fish estrogen receptors are frequently characterized with negative consequences, both at population and individual levels [ 69 , 70 ].…”

Section: Carcinogenic Potentialmentioning

confidence: 99%

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Wojnarowski

Cholewińska

Palić

et al. 2022

IJMS

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Estrogen receptors (ERs) play a key role in many biochemical and physiological processes, that are involved in maintaining organism homeostasis. At the most basic level, they can be divided into nuclear estrogen receptors and membrane estrogen receptors that imply their effect in two ways: slower genomic, and faster non-genomic. In these ways, estrogens and xenoestrogens can negatively affect animal health and welfare. Most of the available literature focuses on human and mammalian physiology, and clearly, we can observe a need for further research focusing on complex mutual interactions between different estrogens and xenoestrogens in aquatic animals, primarily fishes. Understanding the mechanisms of action of estrogenic compounds on the ERs in fishes and their negative consequences, may improve efforts in environmental protection of these animals and their environment and benefit society in return. In this review, we have summarized the ER-mediated effects of xenoestrogens and estrogens on teleost fishes metabolism, their carcinogenic potential, immune, circulatory, and reproductive systems.

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Section: Carcinogenic Potentialmentioning

confidence: 99%

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Wojnarowski

Cholewińska

Palić

et al. 2022

IJMS

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“…A study reported a hormone receptor expression change in female Mongolian gerbils upon exposure to BPA during pregnancy and lactation [ 123 ]. The protein expression level of ERα was increased, but that of ERβ markedly decreased in the epithelial cells of mammary glands exposed to BPA compared to mammary glands exposed to the vehicle or water [ 123 ]. However, the study did not find any alteration in either ERα or ERβ expression in stromal cells after BPA exposure.…”

Section: Fibroblasts and Ecmsmentioning

confidence: 99%

“…However, the study did not find any alteration in either ERα or ERβ expression in stromal cells after BPA exposure. Notably, the same study reported elevated protein expression of enhancer of zeste homolog 2 (EZH2) in BPA-exposed mammary glands [ 123 ]. EZH2 is a histone methyltransferase that catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to ultimately repress transcription.…”

Section: Fibroblasts and Ecmsmentioning

confidence: 99%

“…Dysregulation of EZH2 has been implicated in the development and progression of various cancers, including breast cancer [ 124 ]. These results indicate possible epigenetic modification by BPA treatment in mammary glands, but the involvement of an epigenetic mechanism was not investigated in relation to BPA-induced ER expression changes [ 123 ]. Prenatal exposure to BPA resulted in gene expression changes in collagen genes in adult fibroblasts [ 116 ].…”

Section: Fibroblasts and Ecmsmentioning

confidence: 99%

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Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment

Kwon

2022

Cancers

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BPA, a chemical used in the preparation of polycarbonate plastics, is an endocrine disruptor. Exposure to BPA has been suggested to be a risk factor for breast cancer because of its potential to induce estrogen receptor signaling in breast cancer cells. More recently, it has been recognized that BPA also binds to the G protein-coupled estrogen receptor and other nuclear receptors, in addition to estrogen receptors, and acts on immune cells, adipocytes, and fibroblasts, potentially modulating the TME. The TME significantly impacts the behavior of cancer cells. Therefore, understanding how BPA affects stromal components in breast cancer is imperative to adequately assess the association between exposure to BPA and the risk of breast cancer. This review examines the effects of BPA on stromal components of tumors to highlight their potential role in the carcinogenic effect of BPA. As a result, I propose considerations for the risk assessment of BPA exposure and studies needed to improve understanding of the TME-mediated, breast cancer-promoting effect of BPA.

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“…We recently demonstrated the carcinogenic potential of BPA in MG of elderly gerbil females after previous exposure during pregnancy and lactation (Ruiz, Colleta, Leonel, et al, 2021). Safe (50 µg/kg/daily) and acute (5000 µg/kg/daily) dosages promoted tumoral onset in MG in a long‐term, considering the exposure during pregnancy and lactation (Ruiz, Colleta, Leonel, et al, 2021; Ruiz, Colleta, Zuccari et al, 2021). In these phases an intense remodeling occurs in epithelial and stromal compartments (Terry et al, 2019) and exposure to BPA triggers a late tumor development onset at aging (Ruiz, Colleta, Leonel, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response

Ruiz

Colleta

Santos

et al. 2023

Cell Biology International

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Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption

Cited by 10 publications

References 104 publications

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment

Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response

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