Hormone profile of coeliac disease

Bloom, S.R.; Besterman, HS; Sarson, DI; Stewart, James A.; Guérin, Sylvie; Modigliani, R; Mallinson, C.B.

doi:10.1016/0016-5085(78)93035-4

Cited by 8 publications

(8 citation statements)

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“…However, there is no further evidence to support this point. In light of this consideration, although Montén et al in a recent pediatric study [18] have suggested a potential role of pro-NT in CD, we aimed to evaluate a potential involvement of NT, echoing previous studies [14][15][16][17]. It is unquestionable that it would be interesting to evaluate both NT and pro-NT at the same time, albeit it was not feasible in our study.…”

Section: Gastroenterology Research and Practicementioning

confidence: 93%

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Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

Iorfida

Montuori

Trovato

et al. 2020

Gastroenterology Research and Practice

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Background and Aims. Neurotensin (NT) is a gut hormone secreted by specific endocrine cells scattered throughout the epithelial layer of the small intestine, which has been identified as an important mediator in several gastrointestinal functions and disease conditions. Its potential involvement in celiac disease (CD) has been investigated, but there are conflicting findings. The aim of this study was to evaluate serum NT levels in children with CD at diagnosis, compared to a control group, and to investigate whether NT correlated in CD patients with symptoms, antibody response, and intestinal mucosal damage. Materials and Methods. Children (1-16 years old) undergoing gastrointestinal endoscopy for CD or for other clinical reasons were included in this study. Patients with CD diagnosed according to the 2012 European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines without biopsy were also recruited. Fasting serum samples were analyzed for NT levels using ELISA. Logistic regression, Wilcoxon rank sum, and Spearman’s rank tests were used for statistical analysis. Results. Thirty children (18 females, 2.2-15.9 years old) were enrolled. Of 25 patients who underwent endoscopy, 9 were CD patients, 13 were controls, and 3 were excluded due to nonspecific inflammation at duodenal biopsy. CD was diagnosed in 5 patients without biopsy. NT median was higher in CD patients compared to controls (13.25 (IQR 9.4-17.5) pg/ml vs. 7.8 (IQR 7.6-10) pg/ml; p=0.02). No statistically significant association between NT and clinical, serological, or histological data of CD was observed in this CD cohort. Conclusions. To our knowledge, this is the first study that evaluates NT in CD children from Italy. Results show that NT is higher in the serum of CD children at diagnosis compared to controls. However, larger-scale studies are required to validate these findings. Whether serum NT levels can be an adjunctive marker for pediatric CD remains currently elusive.

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Section: Gastroenterology Research and Practicementioning

confidence: 93%

“…In 1978, Bloom et al showed that patients with untreated CD had an increase in postprandial NT levels compared to healthy controls and CD subjects on a gluten-free diet [14]. In that year, the same group of authors assessed the profile of intestinal hormones in CD patients, showing in these subjects an increase in fasting NT levels [15].…”

Section: Introductionmentioning

confidence: 99%

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

Iorfida

Montuori

Trovato

et al. 2020

Gastroenterology Research and Practice

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“…In earlier studies, various degrees of exocrine pancreatic dysfunction have been documented in association with villous atrophy using direct or indirect methods other than the fecal elastase test (16). The same mechanism has been postulated in those studies, which have documented failure of secretin and cholecystokinin release in untreated patients with celiac disease (17,18). Jejunal mucosal integrity is necessary for the normal secretion of enteric hormones by the respective cells located in the small intestinal mucosa.…”

mentioning

confidence: 84%

Fecal Elastase‐1 Concentration: An Indirect Test of Exocrine Pancreatic Function and a Marker of an Enteropathy Regardless of Cause

Nousia‐Arvanitakis

2003

J. pediatr. gastroenterol. nutr.

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“…An early study showed that untreated coeliac disease patients displayed increased postprandial plasma NT release compared to healthy controls and patients on a gluten-free diet [19]. An early study showed that untreated coeliac disease patients displayed increased postprandial plasma NT release compared to healthy controls and patients on a gluten-free diet [19].…”

Section: Introductionmentioning

confidence: 99%

“…Studies on NT in coeliac disease pathogenesis are scarce, and existing results are diverse. An early study showed that untreated coeliac disease patients displayed increased postprandial plasma NT release compared to healthy controls and patients on a gluten-free diet [19]. Another conflicting study observed impaired postprandial plasma NT release in untreated coeliac disease patients, despite increased preprandial plasma NT levels [20].…”

Section: Introductionmentioning

confidence: 99%

Role of proneurotensin as marker of paediatric coeliac disease

Montén

Naluai

Agardh

2016

Clinical and Experimental Immunology

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Neurotensin (NT) is a gut hormone functioning proinflammatory through nuclear factor kappa B (NF-κB) and interleukin (IL)-8 secretion or anti-inflammatory through epidermal growth factor receptors. NT mRNA is down-regulated in duodenal biopsies of children with untreated coeliac disease. The aim of this study was to investigate if plasma pro-NT levels correlated with the degree of intestinal mucosal damage and tissue transglutaminase autoantibody (tTGA) levels in children with coeliac disease. Fasting plasma samples from 96 children with coeliac disease and 89 non-coeliac disease controls were analysed for NT precursor fragment pro-NT 1-117 by a chemiluminometric immunoassay. Pro-NT levels were compared with NT mRNA from duodenal biopsies, assessed previously with quantitative polymerase chain reaction (PCR). Illumina core exome arrays were used for human leucocyte antigen (HLA) typing and the Marsh criteria applied to score mucosal damage. Tissue TGA was measured by radio binding assay. A general linear model compared pro-NT levels with diagnosis of coeliac disease, Marsh score and HLA DQ haplotype. Spearman's rank test was used to compare pro-NT levels with tTGA, age and duodenal NT mRNA levels, respectively. Plasma pro-NT levels were elevated in children with coeliac disease (median 23 pmol/l higher, P = 0·003) and in those with severe intestinal mucosal damage (median 24 pmol/l higher for ≥ Marsh 3b versus not, P = 0·0004). Pro-NT levels correlated further with tTGA (r = 0·22, P = 0·002), but not with duodenal NTS mRNA levels (r = -0·12, P = 0·14). Pro-NT was not associated with any of the HLA risk-haplotypes. Elevated peripheral pro-NT levels reflect more severe forms of active coeliac disease, indicating a potential role of NT in intestinal inflammation.

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Hormone profile of coeliac disease

Cited by 8 publications

References 0 publications

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

Fecal Elastase‐1 Concentration: An Indirect Test of Exocrine Pancreatic Function and a Marker of an Enteropathy Regardless of Cause

Role of proneurotensin as marker of paediatric coeliac disease

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