Hormone-linked redox status and its modulation by antioxidants

Sahoo, Dipak Kumar; Chainy, G.B.N.

doi:10.1016/bs.vh.2022.10.007

Cited by 15 publications

(29 citation statements)

References 207 publications

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“…Clinical oxidative indicators that can detect the byproducts of ROS damage to membrane lipids, proteins, and nuclear components include measurement of malondialdehyde (MDA), F2-isoprostanes, and 8-hydroxy-2’-deoxyguanosine ( Sahoo and Chainy, 2023 ). Endogenous antioxidant enzymes, including CAT, SOD, and glutathione peroxidases (GPx), also serve as important biomarkers of OS.…”

Section: Sepsis and Oxidative Stressmentioning

confidence: 99%

“…Antioxidant therapy is widely used in cases of OS damage. Antioxidants come in several forms, each with its own unique mechanism of action and clinical use ( Sahoo et al., 2008b ; Prauchner, 2017 ; Chainy and Sahoo, 2020 ; Toro-Pérez and Rodrigo, 2021 ; Ilango et al., 2022 ; Patani et al., 2023 ; Sahoo and Chainy, 2023 ; Sahoo et al, 2023a ). Although oxidative damage is commonly observed in various organs during the progression of sepsis and there exists a direct association between oxidative markers and organ damage, the efficacy of antioxidant effects appears to be contingent not only on the reduction of oxidative damage but also on its anti-inflammatory properties.…”

Section: Antioxidant Treatmentmentioning

confidence: 99%

“…Natural vitamin E, an efficacious lipid-soluble antioxidant, comprises a composite of eight chemically disparate entities, specifically α-, β-, γ- and δ-tocopherols, as well as α-, β-, γ- and δ-tocotrienols ( Sen et al., 2007 ). Vitamin E, specifically α-tocopherol, being an endogenous antioxidant, functions by interrupting the chain reactions initiated by free oxygen radicals through the process of hydrogen atom donation, thus effectively safeguarding cells from the detrimental effects of ROS ( Sahoo et al., 2008b , 2019 ; Chainy and Sahoo, 2020 ; Sahoo and Chainy, 2023 ). While the incorporation of free α-tocopherol and α-tocopherol acetate into alveolar macrophage membranes is limited in vitro , resulting in negligible impact on cellular activation, α-tocopherol succinate exhibits enhanced solubility and rapid cellular uptake in vitro ( Bulger and Maier, 2003 ).…”

Section: Antioxidant Treatmentmentioning

confidence: 99%

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Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Sahoo,

Wong,

Patani

et al. 2024

Front. Cell. Infect. Microbiol.

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Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an imbalanced immune response to infection. Although an increased inflammatory response significantly contributes to the pathogenesis of sepsis, several molecular mechanisms underlying the progression of sepsis are associated with increased cellular reactive oxygen species (ROS) generation and exhausted antioxidant pathways. This review article provides a comprehensive overview of the involvement of ROS in the pathophysiology of sepsis and the potential application of antioxidants with antimicrobial properties as an adjunct to primary therapies (fluid and antibiotic therapies) against sepsis. This article delves into the advantages and disadvantages associated with the utilization of antioxidants in the therapeutic approach to sepsis, which has been explored in a variety of animal models and clinical trials. While the application of antioxidants has been suggested as a potential therapy to suppress the immune response in cases where an intensified inflammatory reaction occurs, the use of multiple antioxidant agents can be beneficial as they can act additively or synergistically on different pathways, thereby enhancing the antioxidant defense. Furthermore, the utilization of immunoadjuvant therapy, specifically in septic patients displaying immunosuppressive tendencies, represents a promising advancement in sepsis therapy.

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Section: Sepsis and Oxidative Stressmentioning

confidence: 99%

Section: Antioxidant Treatmentmentioning

confidence: 99%

Section: Antioxidant Treatmentmentioning

confidence: 99%

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Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Sahoo,

Wong,

Patani

et al. 2024

Front. Cell. Infect. Microbiol.

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“…These compounds are widely used as food supplements and showed important antiinflammatory, antioxidant and anti-cancer effects [36,[38][39][40][41]. Hormone and metabolic compounds can also interact with oxidative metabolism affecting tumoral cell growth [42][43][44].…”

Section: Nrf2 Modulation By Natural Compoundsmentioning

confidence: 99%

Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Tossetta

Fantone

Marzioni

et al. 2023

Cancers

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Prostate cancer is the second most common cancer in men worldwide. Prostate cancer can be treated by surgery or active surveillance when early diagnosed but, when diagnosed at an advanced or metastatic stage, radiation therapy or androgen-deprivation therapy is needed to reduce cancer progression. However, both of these therapies can cause prostate cancer resistance to treatment. Several studies demonstrated that oxidative stress is involved in cancer occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related factor 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays an important role in protecting cells against oxidative damage. Reactive oxygen species (ROS) levels and NRF2 activation can determine cell fate. In particular, toxic levels of ROS lead physiological cell death and cell tumor suppression, while lower ROS levels are associated with carcinogenesis and cancer progression. On the contrary, a high level of NRF2 promotes cell survival related to cancer progression activating an adaptive antioxidant response. In this review, we analyzed the current literature regarding the role of natural and synthetic compounds in modulating NRF2/KEAP1 signaling pathway in prostate cancer.

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“…Melatonin’s antioxidant mechanism involves free-radical scavenger cascade indicating efficiency of secondary and tertiary metabolites. Furthermore, melatonin indirectly acts by stimulating antioxidant enzymes ( 19 – 21 ). In fact, it can modulate the mRNA levels and activity of some well-known antioxidants such as Glutathione Peroxidase (GPx), ascorbate, and superoxide dismutase (SOD) ( 15 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models

et al. 2023

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BackgroundModern societies face infertility as a global challenge. There are certain environmental conditions and disorders that damage testicular tissue and may cause male infertility. Melatonin, as a potential antioxidant, may protect testicular tissue. Therefore, we conducted this systematic review and meta-analysis to evaluate the effects of melatonin in animal models against physical, heat, and ischemic damage to the testicular tissue.MethodsPubMed, Scopus, and Web of Science were systematically searched to identify animal trials evaluating the protective effect of melatonin therapy on rodent testicular tissue when it is exposed to physical, thermal, ischemic, or hypobaric oxygen stress. Random-effect modeling was used to estimate the standardized mean difference and 95% confidence intervals based on the pooled data. Additionally, the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used to assess the risk of bias. The study protocol was prospectively registered in PROSPERO (CRD42022354599).ResultsA total of 41 studies were eligible for review out of 10039 records. Studies employed direct heat, cryptorchidism, varicocele, torsion-detorsion, testicular vascular occlusion, hypobaric hypoxia, ischemia-reperfusion, stress by excessive or restraint activity, spinal cord injury, and trauma to induce stress in the subjects. The histopathological characteristics of testicular tissue were generally improved in rodents by melatonin therapy. Based on the pooled data, sperm count, morphology, forward motility, viability, Johnsen’s biopsy score, testicular tissue glutathione peroxidase, and superoxide dismutase levels were higher in the melatonin treatment rodent arms. In contrast, the malondialdehyde level in testicular tissue was lower in the treatment rodent arms. The included studies suffered from a high risk of bias in most of the SYRCLE domains.ConclusionThis study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries. In this regard, melatonin deserves scientific investigations as a potential protective drug against rodent male infertility.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022354599.

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Hormone-linked redox status and its modulation by antioxidants

Cited by 15 publications

References 207 publications

Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models

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