Hormone Imbalance in Women with Infertility Caused by Polycystic Ovary Syndrome: Is There a Connection with Body Mass Index?

Khmil, M. S.; Khmil, Stephan

doi:10.3889/oamjms.2020.4569

Cited by 20 publications

(12 citation statements)

References 42 publications

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“…This may be explained by the theioryical that some PCOS pathogenesis connected to deficient hypothalamic dopaminergic activity, also responsible for raises LH/FSH ratio and thyroid stimulating hormone (Anthony et al, 1984). Furthermore, testosterone with high level in women infected with PCOS proposed that induced or genetic excess of testosterone may be the main cause of obesity relationship with PCOS (Khmil & Marushchak, 2020). Thus, our results are agreement with the recent studies and confirm the importance of hormonal evaluation for PCOS for evolution early to prevent long-term reproductive problems and infertility.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of hormones level in infertility women because of polycystic ovary syndrome

Jassam

Fayez

Abduljabar

2022

ijhs

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Background: Polycystic ovary syndrome refers to an endocrine disruption in affected women during reproductive age. Objective: The current study was undertaken with the objective of investigating the effects of LH, FSH, LH/FSH, prolactin, AMH, and testosterone of secretion and correlate PCOS subjects. Materials and methods: The study included infertile women infected with PCOS and healthy women aged (20-45) collected from May to July 2022 in Iraq. Among 60 women were studied, 40 infected women with PCOS (Patients group) and 20 healthy women (Healthy group) in this study. In all subjects, hormone levels of FSH, LH, AMH, Testosterone, and prolactin samples were taken and tested by VIDAS using commercial kit (BIOMERIEUX-France). Results: The result shown the levels of LH, LH/FSH ratio, AMH, Testosterone, and Prolactin in patient group of women infected with PCOS significant difference compared with control group, as LH, LH/FSH ratio, AMH, Testosterone, and Prolactin higher level in patient group compared with control group. But the levels of FSH in group of women infected with PCOS shown nonsignificant difference compared with control group with decreased nonsignificant in patient group compared with control group.

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Section: Discussionsupporting

confidence: 92%

Evaluation of hormones level in infertility women because of polycystic ovary syndrome

Jassam

Fayez

Abduljabar

2022

ijhs

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“…It is well known that obesity and visceral adiposity worsen the clinical features of menstrual irregularity and infertility 35 and they are correlated with increased serum androgens and LH in female with PCOS. 36 In this study treatment of the PCOS with flavonolignan silibinin displayed the potential alleviation of the hormonal abnormalities and restored the normal estrous cyclicity in the rats. Silibinin treated groups alone and in combination with metformin, did not display any significant increase in body weight compared with the animals in the different groups, which suggested that silibinin might have the suppressive effect on lipid accumulation in adipocytes.…”

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Silibinin Against Polycystic Ovary Syndrome Induced by Letrozole in Rats via Its Potential Anti-Inflammatory and Anti-Oxidant Activities

Marouf¹,

Ismaeel²,

Hassan³

et al. 2022

JIR

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Background Current therapies for polycystic ovary syndrome (PCOS) are accompanied by unwanted effects. Silibinin; a flavonolignan has pleiotropic activities and favorable safety profile. Purpose To investigate the efficacy of silibinin on estrous cyclicity, inflammation, oxidative stress and ovarian morphology in letrozole-induced PCOS in rats. Methods Forty-eight female Wistar albino rats were divided into 2 sets. Rats of the first set (n = 12), assigned as a negative control (NC) received only the vehicle, rats of the second set (n = 36), assigned as PCOS rats, were given letrozole 1mg/Kg orally for 21 days. On day 21, six rats from the first set and six rats from the second set were euthanized for confirmation of PCOS-induction. The remaining animals from the first set assigned as group 1, those in the second set (n = 30) were equally divided into 5 groups and treated daily for 19 days as follows: group 2 (positive control) received only the vehicle, group 3 treated with metformin 300mg/Kg orally, groups 4 and 5 treated respectively with 100 and 200 mg/Kg silibinin intraperitoneally (IP), and group 6 treated with a combination of metformin 300mg/Kg orally and silibinin 100mg/Kg IP. On day 40, blood samples were examined for luteinizing hormone (LH), testosterone (TS) and estradiol (EST) levels, the anti-inflammatory and antioxidant parameters, ovarian and uterine morphology. Results Silibinin alone or in combination with metformin was found to be effective in restoring the regularity of estrous cycle by ameliorating the abnormal alterations of LH, TS, EST, tumor necrosis factor (TNF)-α, and oxidative status and by resuming the appearance of corpora lutea and decreasing or even total absence of cystic follicles in the ovaries. Conclusion Silibinin was effective in restoring estrous regularities and alleviating hormonal and histomorphological abnormalities of the ovarian and uterine tissues, this could be due to its anti-androgenic, anti-inflammatory and antioxidant properties.

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“…Gonadotropic dysfunction and insulin resistance are the primary pathophysiological elements of polycystic ovarian syndrome (PCOS), and both are frequently linked to high body mass index. Menstrual, ovulation, and infertility issues have been linked to obesity (Khmil et al, 2020).…”

Section: Informant Consensus Factormentioning

confidence: 99%

Medicinal plants used in Soran district Kurdistan region of Iraq, an ethnobotanicals study

Abdulwahid-Kurdi¹,

Abdulwahid²,

Usman³

et al. 2023

J Pharm Pharmacogn Res

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Context: The current study, the first of its type, focuses on the ethnobotanical uses of 97 medicinal plant species by the inhabitants in the Soran area, Kurdistan region of Iraq. Aims: To evaluate local knowledge of medicinal plants and provision of preliminary data on the user-benefit of the accessible plant species in the area. Methods: Between October 2021 and May 2022, key informant interviews were conducted as part of an ethnobotanical survey. Information about a particular study through face-to-face interviews with 171 participants (98 males and 73 females) were collected. For the therapeutic plants considered in the study, quantitative indices such as use value (UV), family use value (FUV), the relative frequency of citation (RFC), fidelity level (FL), and informant consensus factor (ICF) were applied in addition to detailed notes on each plant species. Results: The survey discovered 97 plant species and 41 plant families. Leaves were the plant portion that was used the most (44%) while seeds were the least (12%). The most popular three methods of preparation were decoction (52%), row (36%), and crushed (6%). The Olea europaea species had the highest use values (0.82), while Vitex agnus-castus had (0.005). Amaryllidaceae had the highest family use value (1.218), while Asteraceae had (0.005). According to the consensus index, Ficus carica and Datura stramonium had (140.84%) and (1.011%). The digestive tract disease category was shown to have the highest informant consensus factor value out of all disease categories (0.57), while the lowest value ICF was (0.0) for tooth pain. Conclusions: As a result of the development of natural medicines, this study gives information on the indigenous medicinal plants utilized in the Soran district to treat common illnesses that are ready for additional pharmacological and phytochemical examination. For better use of natural resources, the traditional use of plants requires conservation methods and additional research.

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Hormone Imbalance in Women with Infertility Caused by Polycystic Ovary Syndrome: Is There a Connection with Body Mass Index?

Cited by 20 publications

References 42 publications

Evaluation of hormones level in infertility women because of polycystic ovary syndrome

Evaluation of hormones level in infertility women because of polycystic ovary syndrome

Therapeutic Effects of Silibinin Against Polycystic Ovary Syndrome Induced by Letrozole in Rats via Its Potential Anti-Inflammatory and Anti-Oxidant Activities

Medicinal plants used in Soran district Kurdistan region of Iraq, an ethnobotanicals study

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