Hormone-Glutamine Metabolism: A Critical Regulatory Axis in Endocrine-Related Cancers

Xu, Feng-Yuan; Shi, Jialu; Qin, Xueyun; Zheng, Zi‐Meng; Chen, Min; Lin, Zhiang; Ye, Jiangfeng; Li, Ming‐Qing

doi:10.3390/ijms231710086

Cited by 4 publications

(2 citation statements)

References 164 publications

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“…It is an energy source for biosynthesis and homeostasis [ 202 , 203 , 204 ]. An in-depth understanding is required for regulating Gln-metabolism in cancer cell development and proliferation associated with hormonal studies such as progesterone, thyroid hormone, androgen, estrogen, prostaglandin, and insulin [ 205 ].…”

Section: Metabolic Regulation Of Pcamentioning

confidence: 99%

Role of Metabolism and Metabolic Pathways in Prostate Cancer

et al. 2023

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Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells modify their metabolism in response to an excessive intake of nutrients to facilitate advancement. Metabolic syndrome (MetS) is inextricably linked to the carcinogenic progression of PCa, which heightens the severity of the disease. It is hypothesized that changes in the metabolism of the mitochondria contribute to the onset of PCa. The studies of particular alterations in the progress of PCa are best accomplished by examining the metabolome of prostate tissue. Due to the inconsistent findings written initially, additional epidemiological research is required to identify whether or not MetS is an aspect of PCa. There is a correlation between several risk factors and the progression of PCa, one of which is MetS. The metabolic symbiosis between PCa cells and the tumor milieu and how this type of crosstalk may aid in the development of PCa is portrayed in this work. This review focuses on in-depth analysis and evaluation of the metabolic changes that occur within PCa, and also aims to assess the effect of metabolic abnormalities on the aggressiveness status and metabolism of PCa.

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Section: Metabolic Regulation Of Pcamentioning

confidence: 99%

Role of Metabolism and Metabolic Pathways in Prostate Cancer

et al. 2023

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“…Since the Warburg effect was discovered, abnormal metabolism has been a never-ending topic in the field of cancer research. At present, researchers not only pay attention to glucose metabolism, but also pay attention to other metabolic types, such as glutamine metabolism ( Figure 1 ) [ 15 ]. Abnormal metabolism usually produces a higher expression of hypoxia-inducible factor-1 (HIF-1) that is a critical premise for epithelial to mesenchymal transition (EMT) [ 16 ].…”

Section: Overview Of Cancer Metabolismmentioning

confidence: 99%

Metabolism in Cancer Stem Cells: Targets for Clinical Treatment

Wen

Xiaoyan

2022

Cells

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Cancer stem cells (CSCs) have high tumorigenicity, high metastasis and high resistance to treatment. They are the key factors for the growth, metastasis and drug resistance of malignant tumors, and are also the important reason for the occurrence and recurrence of tumors. Metabolic reprogramming refers to the metabolic changes that occur when tumor cells provide sufficient energy and nutrients for themselves. Metabolic reprogramming plays an important role in regulating the growth and activity of cancer cells and cancer stem cells. In addition, the immune cells or stromal cells in the tumor microenvironment (TME) will change due to the metabolic reprogramming of cancer cells. Summarizing the characteristics and molecular mechanisms of metabolic reprogramming of cancer stem cells will provide new ideas for the comprehensive treatment of malignant tumors. In this review, we summarized the changes of the main metabolic pathways in cancer cells and cancer stem cells.

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