Hormone Dependency of Meningiomas

Blankenstein, Marinus A.; Verlaat, J. W. Van't; Croughs, R. J. M.; Schrell, U.; Adams, Eric F.; Fahlbusch, Rudolf; Williams, Gareth; Ball, J.A.

doi:10.1016/s0140-6736(89)92818-3

Cited by 21 publications

(9 citation statements)

References 5 publications

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“…The availability of specific and well characterized monoclonal antibodies to PR 13' 21, 28, 39 and ER 14 has provided an effective tool for investigating the tissue distribution of these receptors, in contrast to previous assays 4, 7,9,25,30,32,33,42 Our results confirm that ER is undetectable in human meningiomas, as previously observed by Schnegg et al 33 and Blankenstein et al 4' 5, using immunocytochemical assay 4 and binding techniques 5' 33. The availability of specific and well characterized monoclonal antibodies to PR 13' 21, 28, 39 and ER 14 has provided an effective tool for investigating the tissue distribution of these receptors, in contrast to previous assays 4, 7,9,25,30,32,33,42 Our results confirm that ER is undetectable in human meningiomas, as previously observed by Schnegg et al 33 and Blankenstein et al 4' 5, using immunocytochemical assay 4 and binding techniques 5' 33.…”

Section: Discussionsupporting

confidence: 85%

“…It can be surgically removed in most cases. In contrast, studies of progesterone binding have revealed that most human meningiomas have high levels of progesterone binding 7' 25,30,32,33,42 Up to now, steroid binding assays 7,9,25,30,32,33,42 or enzyme immunoassays 6 (EIA) have been used to quantify oestrogen (ER) and progesterone (PR) receptor concentrations in tissue homogenates but the necessary homogenization of tissues has prevented the identification of the cells containing these steroid receptors. Clinical and epidemiological observations regarding meningiomas, such as the predominance of these tumours in women (see review in 17), the aggravation of their symptoms during pregnancy 3,41 and case reports of an association between meningiomas and breast cancer 34, suggest a sex hormone dependency of these tumours.…”

Section: Introductionmentioning

confidence: 99%

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Immunocytochemical study of progesterone receptor in human meningioma

1992

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Progesterone (PR) and oestrogen (ER) receptors were examined in meningiomas from 36 patients, using immunocytochemistry. The present experiments were performed to evaluate: (a) the presence and intracellular localization of these receptors, (b) whether PR immunostaining can be correlated (or not) with proliferation potential, as evaluated by histopathological features or the clinical evolution of this neuropathological tumour. Twenty six tumours (72%) tested were positive for PR but none for ER. The presence of PR immunostaining was more frequently observed in females (79% versus 58% in males) and premenopausal status (84% versus 3/5 in postmenopausal). Correlations of PR immunostaining with the histologic type showed 89% of meningothelial, 4/6 cases of transitional, 1/3 case of fibroblastic and 1/4 cases of anaplastic meningiomas to be immunostained for PR. Staining was confined to tumours arachnoidal cells. A heterogeneous distribution was observed in most PR-positive meningiomas. The preferential immunostaining in meningothelial histological types correlates with the presence of PR in normal arachnoidal cells. The proliferating potential of these meningiomas was evaluated by the immunostaining of an antigen only present in proliferating cells (Ki antigen). There was no significant correlation between PR status and the Ki labelling rate, or rapid clinical evolution. These data were compared with those previously reported. They confirm that the cellular biosynthesis of PR in meningiomas is not oestrogen regulated as it is in other sex steroid tissues, such as the breast and the endometrium.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Immunocytochemical study of progesterone receptor in human meningioma

1992

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“…Some studies have shown no effect [26], some have shown 211 stimulation [19], and others have shown inhibition [27]. The effect of the antiprogesterone mifepristone (RU-486) has been studied both in cell cultures and in an animal model of subcutaneous tumor: in general it inhibits tumor growth [19,28,29], but one study showed that it had no effect on cultured cells [26].…”

Section: Progesterone Studiesmentioning

confidence: 99%

The biology of meningiomas

McCutcheon

1996

J Neuro-Oncol

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Meningiomas, long neglected as a subject for biological studies, are now being examined more widely as their potential for clinical recurrence and malignancy has been recognized. Most laboratory studies have focused on descriptive analyses of the content of various molecules in ex vivo specimens removed at surgery. Perturbative experiments using cultured cells are possible, but they are complicated by senescence of the cells. The respective importance of the sex steroids (estrogen, progesterone, and androgens), classical growth factors, angiogenic factors, and proteolytic enzymes in the biological behavior of meningiomas is now apparent and is coming under more detailed scrutiny. As general theories of neoplasia crystallize in other systems, the ability of meningiomas to proliferate, invade, and provoke neovascularization will be better understood.

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“…Various researchers have used in vitro and in vivo studies to demonstrate the ability of PR's to affect meningioma growth. 5,16,43 The discrepancy between these results may be explained by the fact that meningioma cells in vitro lose their ability to express PR's and transform into fibroblastlike cells after a few passages. 14,19 Furthermore, conflicting results regarding inhibition of the growth of meningioma cells in vitro and in vivo were obtained with the progesterone antagonist RU-486.…”

Section: Functional Role Of Pr's In Meningiomasmentioning

confidence: 99%

Quantitative imaging of estrogen and progesterone receptors, estrogen-regulated protein, and growth fraction: immunocytochemical assays in 52 meningiomas

Bouillot

Pellissier²,

Devictor³

et al. 1994

Journal of Neurosurgery

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Quantitative imaging of estrogen receptors (ER's), progesterone receptors (PR's), estrogen-regulated protein (pS2), and growth fraction (Ki67) immunocytochemical assays were performed in 52 meningiomas. The results were correlated with clinical (age, sex, hormonal status, and tumor volume and location) and morphological (histological types and grades) data. The authors observed a lack of ER's in all meningiomas but the presence of PR's in 53% of these meningiomas. The immunoreactivity was restricted to tumor cell nuclei. The PR immunocytochemical assay was correlated with tumor location, histological type, histological grade, and pS2 immunocytochemical assay, but not with Ki67 immunocytochemical assay; high PR content was observed in cisternae, transitional, meningothelial, and low-grade meningiomas. Only 11 meningiomas showed more than 1% Ki67 immunoreactive nuclei. These meningiomas were usually located in the convexity and were of high histological grade. Estrogen-regulated protein immunoreactivity was observed in 34 meningiomas but the number of immunoreactive nuclei was low. The pS2 immunocytochemical assay was not related to clinicopathological features but was preferentially observed in PR-negative meningiomas. The results of this study are compared with those previously reported, and the function and regulation of PR's in meningiomas is discussed. The results indicate that 1) regulation of PR's and pS2 proteins in meningiomas differs from regulation in estrogen-dependent tissues such as breast or endometrium; 2) interruption of hormonal therapy in women presenting with a meningioma is not absolutely necessary; 3) meningiomas have different biological properties according to their clinicopathological features; and 4) future studies of hormonal clinical trials should be performed on well-defined meningioma subgroups.

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Hormone Dependency of Meningiomas

Cited by 21 publications

References 5 publications

Immunocytochemical study of progesterone receptor in human meningioma

Immunocytochemical study of progesterone receptor in human meningioma

The biology of meningiomas

Quantitative imaging of estrogen and progesterone receptors, estrogen-regulated protein, and growth fraction: immunocytochemical assays in 52 meningiomas

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